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7 条记录 (耗时 0.014 秒)

    Method of fabricating a support with dry deposited compounds thereon
    1.
    发明授权
    Method of fabricating a support with dry deposited compounds thereon 失效
    在其上制备具有干淀积化合物的载体的方法

    公开(公告)号：US06368674B1

    公开(公告)日：2002-04-09

    申请号：US09339790

    申请日：1999-06-24

    申请人： Zvi Gerald Loewy ,  William Ronald Roach ,  Bawa Singh

    发明人： Zvi Gerald Loewy ,  William Ronald Roach ,  Bawa Singh

    IPC分类号： B05D106

    CPC分类号： B01L3/5085 ,  B01J2219/00317 ,  B01J2219/00659 ,  B01J2219/00713 ,  C40B60/14

    摘要： Provided is a method of fabricating a solid support with two or more separated regions of a first solid layer of a non-volatile compound deposited thereon, the non-volatile compound required to maintain a chemical proces conducted in a first solution. The method comprises (1) creating an electromagnetic force for attracting charged, solid particles to a surface of the solid support, (2) contacting the surface with the charged particles of non-volatile compound, and depositing the charged particles in an amount effective to provide the non-volatile compound in an amount effective maintain the chemical process.

    摘要翻译： 提供一种制备固体支持物的方法，所述固体支持物具有沉积在其上的非挥发性化合物的第一固体层的两个或更多个分离区域，所述非挥发性化合物需要在第一溶液中进行化学处理。 该方法包括（1）产生用于将带电的固体颗粒吸引到固体支持体的表面的电磁力，（2）使表面与带电荷的非挥发性化合物的颗粒接触，并将带电粒子沉积成有效的量 以有效维持化学过程的量提供不挥发性化合物。

    Deposited reagents for chemical processes
    2.
    发明授权
    Deposited reagents for chemical processes 失效
    沉积的化学工艺试剂

    公开(公告)号：US6045753A

    公开(公告)日：2000-04-04

    申请号：US956737

    申请日：1997-10-23

    申请人： Zvi Gerald Loewy ,  William Ronald Roach ,  Bawa Singh

    发明人： Zvi Gerald Loewy ,  William Ronald Roach ,  Bawa Singh

    IPC分类号： G01N31/22 ,  B01L3/00 ,  C40B60/14 ,  G01N33/48

    CPC分类号： B01L3/5085 ,  B01J2219/00317 ,  B01J2219/00659 ,  B01J2219/00713 ,  C40B60/14

    摘要： Provided is a solid support having dry deposited thereon a first solid layer comprising at least a first compound, the compound for use in a chemical process conducted in a first solution. The invention allows stable forms where the first compound is not stable either (i) for storage in the first solution or (ii) in solution with one or more other compounds of the first layer. Also provided is a tray or kit of wells adapted for conducting a chemical process, each well having a deposited thereon a first solid layer comprising one or more compounds for supporting a chemical process conducted in a first solution, wherein addition of the first liquid to each of the wells dissolves said one or more compounds. Fabrication methods, time-release compositions, and methods of conducting chemical processes are further provided.

    摘要翻译： 提供了一种固体支持物，其上具有在其上沉积有第一固体层的固体支持物，所述第一固体层至少包含第一化合物，所述化合物用于在第一溶液中进行的化学过程。 本发明允许稳定的形式，其中第一化合物不稳定（i）用于储存在第一溶液中或（ii）在溶液中与一种或多种其它第一层化合物的溶液。 还提供了适于进行化学过程的孔的托盘或套件，每个孔上沉积有包含一种或多种用于支撑在第一溶液中进行的化学过程的化合物的第一固体层，其中将第一液体加入到每个 的井溶解所述一种或多种化合物。 进一步提供制造方法，时间释放组合物和进行化学方法的方法。

    Solid support with attached molecules
    3.
    发明授权
    Solid support with attached molecules 失效
    具有附着分子的固体支持物

    公开(公告)号：US6004752A

    公开(公告)日：1999-12-21

    申请号：US956348

    申请日：1997-10-23

    申请人： Zvi Gerald Loewy ,  Bawa Singh

    发明人： Zvi Gerald Loewy ,  Bawa Singh

    IPC分类号： G01N33/547 ,  C07B61/00 ,  C07H21/00 ,  C07H21/04 ,  C12M1/00 ,  C12N15/09 ,  C12Q1/68

    CPC分类号： C12Q1/6837 ,  C07H21/00 ,  C12Q1/686 ,  C12Q1/6862 ,  C07B2200/11 ,  C40B40/00

    摘要： Provided is a solid support having a composition of at least one compound deposited thereon by electrostatic or controlled field deposition, wherein the compound is attached to the support. Also provided is a method of preparing the solid support by creating an electromagnetic force for attracting particles having a first charge to a surface of the solid support and contacting the surface with the charged particles, which comprise the composition, and thereby coating the surface with the composition. Further provided is a probe array comprising spatially resolved probes deposited and attached on a solid support by electrostatic or controlled field deposition. These methods, supports and arrays provide the building blocks for methods of nucleic acid amplification and for constructing apparatuses for conducting chemical processes.

    摘要翻译： 提供一种固体支持物，其具有通过静电或受控的场沉积沉积在其上的至少一种化合物的组合物，其中该化合物连接到载体上。 还提供了一种通过产生用于将具有第一电荷的颗粒吸引到固体支持体的表面并使表面与包含该组合物的带电粒子接触的电磁力来制备固体支持物的方法，从而将该表面与 组成。 进一步提供的探针阵列包括通过静电或受控场沉积沉积并附着在固体支持物上的空间分辨探针。 这些方法，支持和阵列为核酸扩增方法和构建用于进行化学过程的装置提供了基础。

    Automated sample processor
    6.
    发明授权
    Automated sample processor 失效
    自动样品处理器

    公开(公告)号：US06387710B1

    公开(公告)日：2002-05-14

    申请号：US09433155

    申请日：1999-11-03

    申请人： Zvi Gerald Loewy ,  Christopher Carter Gregory ,  Zygmunt Marian Andrevski

    发明人： Zvi Gerald Loewy ,  Christopher Carter Gregory ,  Zygmunt Marian Andrevski

    IPC分类号： G01N110

    CPC分类号： B01L3/502 ,  B01L2400/0478 ,  B01L2400/0622 ,  B01L2400/0644 ,  Y10T436/25375 ,  Y10T436/255 ,  Y10T436/2575

    摘要： Provided is a liquid handling device comprising: a cylindrical actuator cavity in a substrate, the actuator cavity intersected by two or more actuator channels; one or more chambers with an access channel adapted to connect to a separate one of actuator channels; and a actuator comprising (a) a cylindrical body having a cylinder axis and having therein a liquid-handling compartment with, arrayed along the cylinder axis, a first end and a second end, the liquid-handling compartment being closed at the second end, (b) a dispensing channel located at the second end and traversing the cylindrical body, the dispensing channel adapted to be separately aligned with the actuator channels, wherein the actuator is adapted to receive in a seal-tight manner a plunger that operates to confine an effective chamber defined by the plunger and the second end by moving toward the second end or to expand the effective chamber by moving toward the first end. Preferably, one or more of the chambers are formed within the substrate.

    摘要翻译： 提供了一种液体处理装置，包括：在基板中的圆柱形致动器空腔，致动器空腔与两个或更多个致动器通道相交; 一个或多个腔室，其具有适于连接到单独的一个致动器通道的进入通道; 以及致动器，包括（a）具有气缸轴线的圆筒体，并且具有沿着气缸轴线排列的液体处理室，第一端和第二端，液体处理室在第二端处封闭， （b）分配通道，位于第二端并横穿圆柱体，分配通道适于与致动器通道单独对准，其中致动器适于以密封方式接收柱塞，其操作以限制 通过朝向第二端移动而通过柱塞和第二端限定的有效室，或者通过向第一端移动而使有效室膨胀。 优选地，一个或多个室形成在衬底内。