HYDROPHOBIC MONOMERS, HYDROPHOBICALLY-DERIVATIZED SUPPORTS, AND METHODS OF MAKING AND USING THE SAME
    2.
    发明申请
    HYDROPHOBIC MONOMERS, HYDROPHOBICALLY-DERIVATIZED SUPPORTS, AND METHODS OF MAKING AND USING THE SAME 审中-公开
    疏水性单体,疏水性衍生物的支持物及其制备方法和使用方法

    公开(公告)号:US20160325268A1

    公开(公告)日:2016-11-10

    申请号:US15213572

    申请日:2016-07-19

    Abstract: A filtration media is disclosed comprising a hydrophobic monomer grafted onto a support, the hydrophobic monomer having the structure: CH2═CR4C(O)NHC(R1R1)(C(R1R1))nC(O)XR3 wherein n is an integer of 0 or 1; R1 is independently selected from at least one of: a hydrogen atom, alkyls, aryls, and alkylaryls, wherein the alkyls, aryls, and alkylaryls have a total of 10 carbon atoms or less; R3 is a hydrophobic group selected from at least one of: alkyls, aryls, alkylaryls and ethers, wherein the alkyls, aryls, alkylaryls and ethers have a total number of carbon atoms ranging from 4 to 30; R4 is H or CH3; X is O or NH. In some embodiments the hydrophobic monomer is derived from an amine or an alcohol (HXR3) that has a hydrophilicity index of 25 or less. Such media may be used in applications such as hydrophobic interaction chromatography.

    Abstract translation: 其中n为0或1的整数; R 1独立地选自氢原子,烷基,芳基和烷基芳基中的至少一个,其中烷基,芳基和烷基芳基总共具有10个或更少的碳原子; R3是选自烷基,芳基,烷基芳基和醚中的至少一种的疏水基团,其中烷基,芳基,烷基芳基和醚的总碳原子数范围为4-30; R4是H或CH3; X是O或NH。 在一些实施方案中,疏水性单体衍生自亲水性指数为25以下的胺或醇(HXR3)。 这样的介质可以用于诸如疏水相互作用层析的应用中。

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