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公开(公告)号：US11366119B2
公开(公告)日：2022-06-21
申请号：US15990189
申请日：2018-05-25
Applicant: ACADEMIA SINICA
Inventor： Huan-Cheng Chang , Feng-Jen Hsieh , Yen-Wei Chen
IPC: G01N33/543 , G01N33/58
Abstract: This invention is a functionalized diamond crystal with high dispersibility in high ionic strength solution and/or with specific targeting ability, which comprise a diamond crystal and a fatty acid layer. The fatty acid layer works a surfactant and provides a specific targeting feature for the diamond crystal. The feature of the surfactant makes the diamond crystal being easily dispersed in biological surrounding (e.g., phosphate saline buffer) and the feature of specific targeting ability provides the diamond crystal with specific recognizing specific targets. This invention allows researchers to use diamond crystal as a marker for specific labelling.
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公开(公告)号：US11029421B2
公开(公告)日：2021-06-08
申请号：US16557268
申请日：2019-08-30
Inventor： Bing-Ming Cheng , Hsiao-Chi Lu , Jen-Iu Lo , Huan-Cheng Chang
IPC: G01J1/58 , G01T1/202 , G01J1/42 , H01L31/0232 , H01L31/09
Abstract: The present disclosure provides a fluorescent nitrogen-vacancy diamond (FNVD) having a plurality of nitrogen-vacancy centers with a concentration about 1 ppm to 10,000 ppm. The FNVD as built-in fluorophores exhibit a nearly constant emission profile over 540 nm to 850 nm upon excitation by vacuum ultraviolet (VUV), extreme ultraviolet (EUV) and X-rays for the energy larger than 6.2 eV. Applying the FNVD sensor can measure VUV/EUV/X-rays as a sensing sheet, manufacturing method and uses thereof, sensor and lithography apparatus. The superb photostability and broad applicability of FNVDs offer a promising solution for the long-standing problem of lacking robust and reliable detectors for VUV, EUV, and X-rays.
