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公开(公告)号:US20130189286A1
公开(公告)日:2013-07-25
申请号:US13830899
申请日:2013-03-14
申请人: AGENSYS, INC. , Seattle Genetics
发明人: Daulet SATPAEV , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Jean Gudas , Aya Jakobovits , Michael Torgov , Zili An
IPC分类号: A61K47/48
CPC分类号: A61K47/6851 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6889 , A61K2039/505 , A61N5/1001 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K2317/14 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要: Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.