公开(公告)号：US20020146370A1

公开(公告)日：2002-10-10

申请号：US09816703

申请日：2001-03-23

申请人： AGY THERAPEUTICS

发明人： Sabine Mueller ,  Thorsten Melcher ,  Daniel J. Chin

IPC分类号： A61K051/00 ,  A61M036/14

CPC分类号： A61K51/1093 ,  A61K47/6871 ,  A61K51/1075

摘要： The present invention relates to the use of proteins which are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor treatment therapies. Specifically, the present invention relates to the use of immunotherapeutic and immunoimaging agents which specifically bind to human protein tyrosine phosphatase-zeta (PTPnull) for the treatment and visualization of brain tumors in patients. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention.

摘要翻译： 本发明涉及与正常脑组织相比，在原发性脑肿瘤组织中差异表达的蛋白质作为脑肿瘤治疗疗法的生物分子靶标的用途。 具体地，本发明涉及特异性结合人蛋白质酪氨酸磷酸酶ζ（PTP＆xgr）的免疫治疗和免疫成像剂用于治疗和观察患者脑肿瘤的用途。 本发明还提供了用于本发明方法中给药的化合物和药学上可接受的组合物。