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1.KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY 有权
标题翻译: KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用公开(公告)号:US20100003195A1
公开(公告)日:2010-01-07
申请号:US12480578
申请日:2009-06-08
申请人: Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert C. Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski
发明人: Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert C. Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski
IPC分类号: A61K49/22
CPC分类号: A61K49/221 , A61K38/00 , A61K47/62 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/411 , Y02A50/58
摘要: The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
摘要翻译: 本发明提供了包含用于KDR或VEGF / KDR复合物的至少一个结合部分的多肽,肽二聚体和多聚体复合物,其具有各种用途,无论何处治疗,检测,分离或定位血管发生都是有利的。 特别公开的是能够以高亲和力(例如具有KD <1μM)结合KDR或VEGF / KDR复合物的合成,分离的多肽,以及包含这些多肽的二聚体和多聚体构建体。
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2.KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy 有权
标题翻译: KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用公开(公告)号:US08642010B2
公开(公告)日:2014-02-04
申请号:US12480578
申请日:2009-06-08
申请人: Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert C. Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Feng Yan , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski
发明人: Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert C. Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Feng Yan , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski
CPC分类号: A61K49/221 , A61K38/00 , A61K47/62 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/411 , Y02A50/58
摘要: The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
摘要翻译: 本发明提供了包含用于KDR或VEGF / KDR复合物的至少一个结合部分的多肽,肽二聚体和多聚体复合物,其具有各种用途,无论何处治疗,检测,分离或定位血管发生都是有利的。 特别公开的是能够以高亲和力(例如具有KD <1μM)结合KDR或VEGF / KDR复合物的合成,分离的多肽,以及包含这些多肽的二聚体和多聚体构建体。
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公开(公告)号:US08663603B2
公开(公告)日:2014-03-04
申请号:US12888736
申请日:2010-09-23
申请人: Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
发明人: Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
IPC分类号: A61B8/00
摘要: The invention provides compositions and methods for therapeutic and diagnostic applications.
摘要翻译: 本发明提供用于治疗和诊断应用的组合物和方法。
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公开(公告)号:US07910088B2
公开(公告)日:2011-03-22
申请号:US11688968
申请日:2007-03-21
申请人: Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield , Feng Yan
发明人: Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield , Feng Yan
IPC分类号: A61B8/00
CPC分类号: A61K47/48246 , A61K38/16 , A61K47/42 , A61K47/60 , A61K47/64 , A61K49/221 , A61K49/223 , C07K7/08 , C07K7/64 , Y02A50/411
摘要: The invention provides compositions and methods for therapeutic and diagnostic applications.
摘要翻译: 本发明提供用于治疗和诊断应用的组合物和方法。
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公开(公告)号:US20110070165A1
公开(公告)日:2011-03-24
申请号:US12888736
申请日:2010-09-23
申请人: Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
发明人: Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
摘要: The invention provides compositions and methods for therapeutic and diagnostic applications.
摘要翻译: 本发明提供用于治疗和诊断应用的组合物和方法。
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公开(公告)号:US08632753B2
公开(公告)日:2014-01-21
申请号:US12972965
申请日:2010-12-20
申请人: Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
发明人: Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
CPC分类号: A61K47/48246 , A61K38/16 , A61K47/42 , A61K47/60 , A61K47/64 , A61K49/221 , A61K49/223 , C07K7/08 , C07K7/64 , Y02A50/411
摘要: The invention provides compositions and methods for therapeutic and diagnostic applications.
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公开(公告)号:US20110286929A1
公开(公告)日:2011-11-24
申请号:US12972965
申请日:2010-12-20
申请人: Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
发明人: Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
CPC分类号: A61K47/48246 , A61K38/16 , A61K47/42 , A61K47/60 , A61K47/64 , A61K49/221 , A61K49/223 , C07K7/08 , C07K7/64 , Y02A50/411
摘要: The invention provides compositions and methods for therapeutic and diagnostic applications.
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8.PEPTIDES THAT SPECIFICALLY BIND HGF RECEPTOR (CMET) AND USES THEREOF 审中-公开
标题翻译: 特异性结合HGF受体(CMET)的特异性及其用途公开(公告)号:US20120039802A1
公开(公告)日:2012-02-16
申请号:US13227213
申请日:2011-09-07
申请人: Daniel T. DRANSFIELD , Aaron K. Sato , Robert Charles Ladner , Regi Thomas , Palaniappa Nanjappan
发明人: Daniel T. DRANSFIELD , Aaron K. Sato , Robert Charles Ladner , Regi Thomas , Palaniappa Nanjappan
CPC分类号: C07K7/08 , A61K47/543 , A61K47/60 , A61K47/665 , A61K49/0043 , A61K49/0056 , A61K51/08 , B82Y5/00 , C07K14/00 , C07K14/4753
摘要: A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed.
摘要翻译: 公开了具有结合cMet或包含cMet和HGF的复合物的能力的多肽或多聚体多肽构建体及其使用方法。
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9.Peptides that specifically bind HGF receptor (CMET) and uses thereof 有权
标题翻译: 特异性结合HGF受体(CMET)的肽及其用途公开(公告)号:US20100261875A1
公开(公告)日:2010-10-14
申请号:US12012011
申请日:2008-01-30
CPC分类号: C07K7/08 , A61K47/543 , A61K47/60 , A61K47/665 , A61K49/0043 , A61K49/0056 , A61K51/08 , B82Y5/00 , C07K14/00 , C07K14/4753
摘要: A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed.
摘要翻译: 公开了具有结合cMet或包含cMet和HGF的复合物的能力的多肽或多聚体多肽构建体及其使用方法。
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公开(公告)号:US20120322744A1
公开(公告)日:2012-12-20
申请号:US13463378
申请日:2012-05-03
申请人: Arthur C. Ley , Aaron K. Sato , Robert C. Ladner , Mark Stochl
发明人: Arthur C. Ley , Aaron K. Sato , Robert C. Ladner , Mark Stochl
摘要: Disclosed are compounds that comprise: (i) a Kunitz domain polypeptide that comprises a Kunitz domain that binds to and inhibits a protease; and (ii) a plurality of polyethylene glycol moieties attached to the Kunitz domain polypeptide. Each accessible primary amine of the Kunitz domain polypeptide can be attached to one of the moieties. Also disclosed are related methods.
摘要翻译: 公开的化合物包括:(i)Kunitz结构域多肽,其包含结合并抑制蛋白酶的Kunitz结构域; 和(ii)连接到Kunitz结构域多肽的多个聚乙二醇部分。 Kunitz结构域多肽的每个可接触的伯胺可以连接到其中一个部分。 还公开了相关方法。
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