公开(公告)号：US20220251101A1

公开(公告)日：2022-08-11

申请号：US17717486

申请日：2022-04-11

申请人： AbbVie Inc.

发明人： Ayman ALLIAN ,  Jayanthy JAYANTH ,  Mohamed-Eslam F. MOHAMED ,  Mathew MULHERN ,  Fredrik Lars NORDSTROM ,  Ahmed A. OTHMAN ,  Michael J. ROZEMA ,  Lakshmi BHAGAVATULA ,  Patrick J. MARROUM ,  Peter T. MAYER ,  Ahmad Y. SHEIKH ,  Thomas B. BORCHARDT ,  Ben KLÜNDER

IPC分类号： C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and various spondyloarthritic conditions, including types of axial spondyloarthritis (axSpA)), kits, methods of synthesis, and products-by-process. In various aspects, provided are methods for treating active non-radiographic axSpA (nr-axSpA) and methods for treating active ankylosing spondylitis (AS).

公开(公告)号：US20190315761A1

公开(公告)日：2019-10-17

申请号：US16453684

申请日：2019-06-26

申请人： AbbVie Inc.

发明人： Ayman ALLIAN ,  Jayanthy JAYANTH ,  Ben KLÜNDER ,  Mohamed-Eslam F. MOHAMED ,  Ahmed A. OTHMAN ,  Patrick J. MARROUM ,  Peter T. MAYER

IPC分类号： C07D487/14 ,  A61K31/4985 ,  A61K9/00 ,  A61K47/38 ,  A61K47/12

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20200181158A1

公开(公告)日：2020-06-11

申请号：US16787251

申请日：2020-02-11

申请人： AbbVie Inc.

发明人： Ayman ALLIAN ,  Jayanthy JAYANTH ,  Ben KLÜNDER ,  Mohamed-Eslam F. MOHAMED ,  Ahmed A. OTHMAN ,  Patrick J. MARROUM ,  Peter T. MAYER

IPC分类号： C07D487/14 ,  A61K47/38 ,  A61K47/12 ,  A61K31/4985 ,  A61K9/00

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20190046527A1

公开(公告)日：2019-02-14

申请号：US15917013

申请日：2018-03-09

申请人： AbbVie Inc.

发明人： Roopal B. THAKKAR ,  Steven JUNGERWIRTH ,  Ana Paula Machado de LACERDA ,  Anne M. ROBINSON ,  Jose Jeffrey V. ENEJOSA ,  Aileen L. PANGAN ,  Mohamed-Eslam F. MOHAMED ,  Ahmed A. OTHMAN ,  Ben KLÜNDER

IPC分类号： A61K31/4985 ,  A61P1/00 ,  A61K9/48 ,  A61K9/00

摘要： The present disclosure is directed to methods for treating Crohn's disease, and in particular, to methods for inducing clinical remission and/or endoscopic improvement of Crohn's disease, using a JAK1 inhibitor. In certain embodiments, the patient is administered an induction dose of the JAK1 inhibitor to induce clinical remission and/or endoscopic improvement of the Crohn's disease, followed by administration of at least one maintenance dose of the JAK1 inhibitor thereafter. In other embodiments, the present disclosure is directed to methods for treating ulcerative colitis using a JAK1 inhibitor.

公开(公告)号：US20220073530A1

公开(公告)日：2022-03-10

申请号：US17527717

申请日：2021-11-16

申请人： AbbVie Inc.

发明人： Ayman ALLIAN ,  Jayanthy JAYANTH ,  Mohamed-Eslam F. MOHAMED ,  Mathew MULHERN ,  Fredrik Lars NORDSTROM ,  Ahmed A. OTHMAN ,  Michael J. ROZEMA ,  Lakshmi BHAGAVATULA ,  Patrick J. MARROUM ,  Peter T. MAYER ,  Ahmad Y. SHEIKH ,  Thomas B. BORCHARDT ,  Ben KLÜNDER

IPC分类号： C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20190322677A1

公开(公告)日：2019-10-24

申请号：US16458622

申请日：2019-07-01

申请人： AbbVie Inc.

发明人： Ahmed A. OTHMAN ,  Mohamed-Eslam F. MOHAMED ,  Ben KLÜNDER ,  Ayman ALLIAN ,  Aileen L. PANGAN

IPC分类号： C07D487/14 ,  A61K47/12 ,  A61K47/38 ,  A61K9/00 ,  A61K31/4985

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20210363149A1

公开(公告)日：2021-11-25

申请号：US17184194

申请日：2021-02-24

申请人： AbbVie Inc.

发明人： Ayman ALLIAN ,  Jayanthy JAYANTH ,  Mohamed-Eslam F. MOHAMED ,  Mathew M. MULHERN ,  Fredrik Lars NORDSTROM ,  Ahmed A. OTHMAN ,  Michael J. ROZEMA ,  Lakshmi BHAGAVATULA ,  Patrick J. MARROUM ,  Peter T. MAYER ,  Ahmad Y. SHEIKH ,  Thomas B. BORCHARDT ,  Ben KLÜNDER

IPC分类号： C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20210309667A1

公开(公告)日：2021-10-07

申请号：US17230288

申请日：2021-04-14

申请人： AbbVie Inc.

发明人： Ayman ALLIAN ,  Jayanthy JAYANTH ,  Mohamed-Eslam F. MOHAMED ,  Mathew MULHERN ,  Fredrik Lars NORDSTROM ,  Ahmed A. OTHMAN ,  Michael J. ROZEMA ,  Lakshmi BHAGAVATULA ,  Patrick J. MARROUM ,  Peter T. MAYER ,  Ahmad Y. SHEIKH ,  Thomas B. BORCHARDT ,  Ben KLÜNDER

IPC分类号： C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20200291040A1

公开(公告)日：2020-09-17

申请号：US16656237

申请日：2019-10-17

申请人： AbbVie Inc.

发明人： Ayman ALLIAN ,  Jayanthy JAYANTH ,  Mohamed-Eslam F. MOHAMED ,  Mathew M. MULHERN ,  Fredrik Lars NORDSTROM ,  Ahmed A. OTHMAN ,  Michael J. ROZEMA ,  Lakshmi BHAGAVATULA ,  Patrick J. MARROUM ,  Peter T. MAYER ,  Ahmad Y. SHEIKH ,  Thomas B. BORCHARDT ,  Ben KLÜNDER

IPC分类号： C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20190023714A1

公开(公告)日：2019-01-24

申请号：US15891012

申请日：2018-02-07

申请人： AbbVie Inc.

发明人： Ayman ALLIAN ,  Jayanthy JAYANTH ,  Mohamed-Eslam F. MOHAMED ,  Mathew M. MULHERN ,  Lars Fredrick NORDSTROEM ,  Ahmed A. OTHMAN ,  Michael J. ROZEMA ,  Lakshmi BHAGAVATULA ,  Patrick J. MARROUM ,  Peter T. MAYER ,  Ahmad Y. SHEIKH ,  Thomas B. BORCHARDT

IPC分类号： C07D487/14 ,  A61K47/38 ,  A61K31/4985 ,  A61K9/00 ,  A61K47/12

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.