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公开(公告)号:US08853176B2
公开(公告)日:2014-10-07
申请号:US13656024
申请日:2012-10-19
Applicant: AbbVie Inc.
Inventor: Barry M. Bernstein , Rajeev M. Menon , Amit Khatri , Sven Mensing , Sandeep Dutta , Daniel E. Cohen , Thomas J. Podsadecki , Scott C. Brun , Walid M. Awni , Emily O. Dumas , Cheri E. Klein
IPC: A01N43/04 , A61K31/70 , A61K31/4725 , A61K31/497 , A61K31/4178 , A61K31/513 , A61K31/5377 , A61K31/4709 , A61K31/4025
CPC classification number: A61K38/07 , A61K31/4025 , A61K31/4178 , A61K31/427 , A61K31/439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/513 , A61K31/5377 , A61K31/7056 , A61K31/7072 , A61K38/06 , A61K45/06 , A61K2300/00
Abstract: The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to the subject effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), an inhibitor of cytochrome P450 (e.g., ritonavir), and ribavirin.
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公开(公告)号:US20130102557A1
公开(公告)日:2013-04-25
申请号:US13656024
申请日:2012-10-19
Applicant: AbbVie Inc.
Inventor: Barry M. Bernstein , Rajeev M. Menon , Amit Khatri , Sven Mensing , Sandeep Dutta , Daniel E. Cohen , Thomas J. Podsadecki , Scott C. Brun , Walid M. Awni , Emily O. Dumas , Cheri E. Klein
IPC: A61K31/7056 , A61P31/14
CPC classification number: A61K38/07 , A61K31/4025 , A61K31/4178 , A61K31/427 , A61K31/439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/513 , A61K31/5377 , A61K31/7056 , A61K31/7072 , A61K38/06 , A61K45/06 , A61K2300/00
Abstract: The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to the subject effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), an inhibitor of cytochrome P450 (e.g., ritonavir), and ribavirin.
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公开(公告)号:US20150164976A1
公开(公告)日:2015-06-18
申请号:US14628849
申请日:2015-02-23
Applicant: AbbVie Inc.
Inventor: Walid M. Awni , Barry M. Bernstein , Scott C. Brun , Daniel E. Cohen , Emily O. Dumas , Sandeep Dutta , Amit Khatri , Cheri E. Klein , Rajeev M. Menon , Sven Mensing , Thomas J. Podsadecki
IPC: A61K38/07 , A61K31/427 , A61K31/7056 , A61K31/513 , A61K38/05
CPC classification number: A61K38/07 , A61K31/402 , A61K31/4025 , A61K31/4184 , A61K31/426 , A61K31/427 , A61K31/4709 , A61K31/497 , A61K31/513 , A61K31/675 , A61K31/7056 , A61K31/7072 , A61K38/05 , A61K38/12 , A61K45/06 , A61K2300/00
Abstract: The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to the subject effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), an inhibitor of cytochrome P450 (e.g., ritonavir), and ribavirin. The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to the subject effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), an inhibitor of cytochrome P450 (e.g., ritonavir), and ribavirin. The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to the subject effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), an inhibitor of cytochrome P450 (e.g., ritonavir), and ribavirin. The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to the subject effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), an inhibitor of cytochrome P450 (e.g., ritonavir), and ribavirin.
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公开(公告)号:US20140107017A1
公开(公告)日:2014-04-17
申请号:US14138515
申请日:2013-12-23
Applicant: AbbVie Inc.
Inventor: Barry M. Bernstein , Rajeev M. Menon , Amit Khatri , Sven Mensing , Sandeep Dutta , Daniel E. Cohen , Scott C. Brun , Walid M. Awni , Emily O. Dumas , Cheri E. Klein , Thomas J. Podsadecki
IPC: A61K38/12 , A61K31/427 , A61K31/7072 , A61K31/4184 , A61K31/513 , A61K31/4025
CPC classification number: A61K38/07 , A61K31/402 , A61K31/4025 , A61K31/4184 , A61K31/426 , A61K31/427 , A61K31/4709 , A61K31/497 , A61K31/513 , A61K31/675 , A61K31/7056 , A61K31/7072 , A61K38/05 , A61K38/12 , A61K45/06 , A61K2300/00
Abstract: The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to the subject effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), an inhibitor of cytochrome P450 (e.g., ritonavir), and ribavirin.
Abstract translation: 本发明的特征在于用于治疗HCV的无干扰素治疗。 优选地,治疗过程持续时间较短,例如不超过12周。 在一个方面,治疗方法包括向具有HCV感染的受试者施用至少两种直接作用的抗病毒剂和利巴韦林。 例如,治疗包括向受试者施用有效量的治疗剂1,治疗剂2(或治疗剂3),细胞色素P450抑制剂(例如利托那韦)和利巴韦林。
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公开(公告)号:US20140107016A1
公开(公告)日:2014-04-17
申请号:US14138449
申请日:2013-12-23
Applicant: AbbVie Inc.
Inventor: Barry M. Bernstein , Rajeev M. Menon , Amit Khatri , Sven Mensing , Sandeep Dutta , Daniel E. Cohen , Scott C. Brun , Walid M. Awni , Emily O. Dumas , Cheri E. Klein , Thomas J. Podsadecki
IPC: A61K38/12 , A61K31/427 , A61K31/7072 , A61K31/4184 , A61K31/4025 , A61K31/513
CPC classification number: A61K38/07 , A61K31/4025 , A61K31/4184 , A61K31/427 , A61K31/473 , A61K31/513 , A61K31/7072 , A61K38/05 , A61K38/06 , A61K38/12 , A61K45/06 , G06F17/10 , G06F19/12
Abstract: The present invention features interferon- and ribavirin-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents without interferon and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to a subject an effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), and an inhibitor of cytochrome P450 (e.g., ritonavir).
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公开(公告)号:US09452194B2
公开(公告)日:2016-09-27
申请号:US14503849
申请日:2014-10-01
Applicant: AbbVie Inc.
Inventor: Walid M. Awni , Barry M. Bernstein , Scott C. Brun , Daniel E. Cohen , Emily O. Dumas , Sandeep Dutta , Amit Khatri , Cheri E. Klein , Rajeev M. Menon , Sven Mensing , Thomas J. Podsadecki
IPC: A01N43/04 , A61K31/70 , A61K38/07 , A61K31/4025 , A61K31/4178 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/513 , A61K45/06 , A61K31/427 , A61K31/439 , A61K31/7056 , A61K31/7072 , A61K31/5377 , A61K38/06
CPC classification number: A61K38/07 , A61K31/4025 , A61K31/4178 , A61K31/427 , A61K31/439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/513 , A61K31/5377 , A61K31/7056 , A61K31/7072 , A61K38/06 , A61K45/06 , A61K2300/00
Abstract: The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to the subject effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), an inhibitor of cytochrome P450 (e.g., ritonavir), and ribavirin.
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公开(公告)号:US20150196615A1
公开(公告)日:2015-07-16
申请号:US14670734
申请日:2015-03-27
Applicant: AbbVie Inc.
Inventor: Walid M. Awni , Barry M. Bernstein , Scott C. Brun , Daniel E. Cohen , Emily O. Dumas , Sandeep Dutta , Amit Khatri , Cheri E. Klein , Rajeev M. Menon , Sven Mensing , Thomas J. Podsadecki
IPC: A61K38/07 , A61K38/05 , G06F17/10 , A61K45/06 , G06F19/12 , A61K31/513 , A61K31/427
CPC classification number: A61K38/07 , A61K31/4025 , A61K31/4184 , A61K31/427 , A61K31/473 , A61K31/513 , A61K31/7072 , A61K38/05 , A61K38/06 , A61K38/12 , A61K45/06 , G06F17/10 , G16B5/00
Abstract: The present invention features interferon- and ribavirin-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents without interferon and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to a subject an effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), and an inhibitor of cytochrome P450 (e.g., ritonavir).
Abstract translation: 本发明的特征在于用于治疗HCV的干扰素和不含利巴韦林的疗法。 优选地,治疗超过较短的治疗持续时间,例如不超过12周。 在一个方面,所述疗法包括向具有HCV感染的受试者施用至少两种没有干扰素和利巴韦林的直接作用的抗病毒剂。 例如,治疗包括向受试者施用有效量的治疗剂1,治疗剂2(或治疗剂3)和细胞色素P450(例如利托那韦)的抑制剂。
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公开(公告)号:US20150024999A1
公开(公告)日:2015-01-22
申请号:US14503849
申请日:2014-10-01
Applicant: AbbVie Inc.
Inventor: Walid M. Awni , Barry M. Bernstein , Scott C. Brun , Daniel E. Cohen , Emily O. Dumas , Sandeep Dutta , Amit Khatri , Cheri E. Klein , Rajeev M. Menon , Sven Mensing , Thomas J. Podsadecki
IPC: A61K38/07 , A61K38/06 , A61K31/513 , A61K31/7056 , A61K31/427
CPC classification number: A61K38/07 , A61K31/4025 , A61K31/4178 , A61K31/427 , A61K31/439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/513 , A61K31/5377 , A61K31/7056 , A61K31/7072 , A61K38/06 , A61K45/06 , A61K2300/00
Abstract: The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to the subject effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), an inhibitor of cytochrome P450 (e.g., ritonavir), and ribavirin.
Abstract translation: 本发明的特征在于用于治疗HCV的无干扰素治疗。 优选地,治疗过程持续时间较短,例如不超过12周。 在一个方面,治疗方法包括向具有HCV感染的受试者施用至少两种直接作用的抗病毒剂和利巴韦林。 例如,治疗包括给予受试者有效量的治疗剂1,治疗剂2(或治疗剂3),细胞色素P450抑制剂(例如利托那韦)和利巴韦林。
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公开(公告)号:US08809265B2
公开(公告)日:2014-08-19
申请号:US13656012
申请日:2012-10-19
Applicant: AbbVie Inc.
Inventor: Barry M. Bernstein , Rajeev M. Menon , Amit Khatri , Sven Mensing , Sandeep Dutta , Daniel E. Cohen , Thomas J. Podsadecki , Scott C. Brun , Walid M. Awni , Emily O. Dumas , Cheri E. Klein
IPC: A01N37/18 , A61K38/00 , A61P1/16 , A01N43/04 , A61K31/70 , A61K31/4709 , A61K31/7072 , A61K31/4725 , A61K31/4025 , A61K31/501 , A61K45/06 , A61K31/5377 , A61K31/513 , A61K31/4178 , A61K31/473 , A61K31/4196
CPC classification number: A61K38/07 , A61K31/4025 , A61K31/4178 , A61K31/4196 , A61K31/427 , A61K31/4709 , A61K31/4725 , A61K31/473 , A61K31/501 , A61K31/513 , A61K31/5377 , A61K31/7072 , A61K38/05 , A61K45/06 , A61K2300/00
Abstract: The present invention features interferon- and ribavirin-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents without interferon and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to a subject an effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), and an inhibitor of cytochrome P450 (e.g., ritonavir).
Abstract translation: 本发明的特征在于用于治疗HCV的干扰素和不含利巴韦林的疗法。 优选地,治疗超过较短的治疗持续时间,例如不超过12周。 在一个方面,所述疗法包括向具有HCV感染的受试者施用至少两种没有干扰素和利巴韦林的直接作用的抗病毒剂。 例如,治疗包括向受试者施用有效量的治疗剂1,治疗剂2(或治疗剂3)和细胞色素P450(例如利托那韦)的抑制剂。
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公开(公告)号:US20150209403A1
公开(公告)日:2015-07-30
申请号:US14606369
申请日:2015-01-27
Applicant: AbbVie Inc.
Inventor: Walid M. Awni , Prajakta Badri , Daniel E. Cohen , Sandeep Dutta , Amit Khatri , Rajeev M. Menon , Thomas Podsadecki , Akshanth Polepally , Roger Trinh , Tianli Wang , Jiuhong Zha
IPC: A61K38/06 , A61K38/05 , A61K45/06 , A61K31/513
CPC classification number: A61K38/06 , A61K31/4025 , A61K31/427 , A61K31/496 , A61K31/497 , A61K31/513 , A61K31/55 , A61K38/05 , A61K45/06 , C07K5/0804 , A61K2300/00
Abstract: This application features dose adjustment for drugs co-administered with Compound 1, Compound 2 and/or Compound 3.
Abstract translation: 本申请对与化合物1,化合物2和/或化合物3共同施用的药物具有剂量调整。
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