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公开(公告)号:US20150353550A1
公开(公告)日:2015-12-10
申请号:US14715330
申请日:2015-05-18
申请人: AbbVie Inc.
发明人: Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
IPC分类号: C07D471/18
CPC分类号: G01N33/5058 , C07D471/18 , C07D487/10 , C07D487/18 , G01N33/6896 , G01N2800/28 , G01N2800/30
摘要: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译: 本申请涉及式(I),(II),(III),(IV),(V)或(VI)的吲哚和二氢吲哚衍生物,其中a,R1,R2,R3,R4,R5, V,W,X,Y和Z如说明书中所定义。 本申请还涉及包含这些化合物的组合物,以及使用这些化合物和组合物治疗疾病状况的方法,以及鉴定这些化合物的方法。
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公开(公告)号:US20150158867A1
公开(公告)日:2015-06-11
申请号:US14624517
申请日:2015-02-17
申请人: AbbVie Inc.
发明人: Michael R. Schrimpf , Diana L. Nersesian , Kevin B. Sippy , Jianguo Ji , Tao Li , Marc Scanio , Lei Shi , Chih-Hung Lee , William H. Bunnelle , Geoff G.Z. Zhang , Paul J. Brackemeyer , Shuang Chen , Rodger F. Henry
IPC分类号: C07D471/18 , A61K31/439 , A61K31/501 , A61K31/444 , C07C309/29 , A61K31/095
CPC分类号: C07D471/18 , A61K31/095 , A61K31/439 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07C309/29 , C07D451/14 , C07D471/08 , C07F5/022
摘要: The invention relates to compounds that are azaadamantane derivatives, particularly ether- or amine-substituted azaadamantane derivatives and salts and prodrugs thereof, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
摘要翻译: 本发明涉及作为氮杂金刚烷衍生物的化合物,特别是醚取代或胺取代的氮杂金刚烷衍生物及其盐和前体药物,包含这些化合物的组合物,使用这些化合物和组合物的方法,制备这些化合物的方法以及在此过程中获得的中间体 。
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公开(公告)号:US08987453B2
公开(公告)日:2015-03-24
申请号:US13653192
申请日:2012-10-16
申请人: AbbVie Inc.
发明人: Michael R. Schrimpf , Diana L. Nersesian , Kevin B. Sippy , Jianguo Ji , Tao Li , Marc Scanio , Lei Shi , Chih-Hung Lee , William H. Bunnelle , Geoff G. Z. Zhang , Paul J. Brackemeyer , Shuang Chen , Rodger F. Henry
IPC分类号: C07D471/18 , A61K45/06 , A61K31/444 , C07D471/08 , C07F5/02 , A61K31/439 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506
CPC分类号: C07D471/18 , A61K31/095 , A61K31/439 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07C309/29 , C07D451/14 , C07D471/08 , C07F5/022
摘要: The invention relates to compounds that are azaadamantane derivatives, particularly ether- or amine-substituted azaadamantane derivatives and salts and prodrugs thereof, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
摘要翻译: 本发明涉及作为氮杂金刚烷衍生物的化合物,特别是醚取代或胺取代的氮杂金刚烷衍生物及其盐和前体药物,包含这些化合物的组合物,使用这些化合物和组合物的方法,制备这些化合物的方法以及在此过程中获得的中间体 。
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公开(公告)号:US20130096132A1
公开(公告)日:2013-04-18
申请号:US13653192
申请日:2012-10-16
申请人: AbbVie Inc.
发明人: Michael R. Schrimpf , Diana L. Nersesian , Kevin B. Sippy , Jianguo Ji , Tao Li , Marc Scanio , Lei Shi , Chih-Hung Lee , William H. Bunnelle , Geoff G.Z. Zhang , Paul J. Brackemeyer , Shuang Chen , Rodger F. Henry
IPC分类号: C07D471/18 , A61K45/06 , A61K31/501 , A61K31/496 , A61K31/506 , A61K31/497 , A61K31/439 , A61K31/444
CPC分类号: C07D471/18 , A61K31/095 , A61K31/439 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07C309/29 , C07D451/14 , C07D471/08 , C07F5/022
摘要: The invention relates to compounds that are azaadamantane derivatives, particularly ether- or amine-substituted azaadamantane derivatives and salts and prodrugs thereof, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
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公开(公告)号:US20220213092A1
公开(公告)日:2022-07-07
申请号:US17552396
申请日:2021-12-16
申请人: AbbVie Inc.
发明人: David A. DeGoey , Felix DeAnda, Jr. , Amanda W. Dombrowski , Igor Dubovyk , Stephen N. Greszler , Dimitri Khrakovsky , Chih-Hung Lee , James N. Newton , Elizabeth L. Noey , Akinori Okano , Kevin B. Sippy , Andrew J. Souers , Longcheng Wang , Noel S. Wilson , Jeffery A. Zablocki
IPC分类号: C07D471/04 , C07D519/00 , C07D487/04
摘要: The present invention provides for compounds of formula (I) wherein A, R1, R2, R4, W, m, and n have any of the values defined herein, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of CLL and/or SLL.
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公开(公告)号:US20160022658A1
公开(公告)日:2016-01-28
申请号:US14877783
申请日:2015-10-07
申请人: AbbVie Inc.
发明人: Murali Gopalakrishnan , Marie P. Honore , Chih-Hung Lee , John Malysz , Jianguo Ji , Tao Li , Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson
IPC分类号: A61K31/4439 , A61K31/444 , G01N33/94 , C07D413/04 , C07D413/14 , A61K45/06 , A61K31/4427 , A61K31/4709
CPC分类号: A61K31/4439 , A61K31/4245 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/4709 , A61K45/06 , C07D413/04 , C07D413/14 , G01N33/944 , G01N2333/70571 , A61K2300/00
摘要: The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.
摘要翻译: 本发明涉及包含神经元烟碱性受体配体和α4和bgr2阳性变构调节剂,其使用方法和相关制品的组合物。
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