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公开(公告)号:US08859548B2
公开(公告)日:2014-10-14
申请号:US14022540
申请日:2013-09-10
申请人: Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew , Qiong Zhang
发明人: Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew , Qiong Zhang
IPC分类号: A61K31/50 , A61K45/06 , A61K31/506 , C07D403/04
CPC分类号: C07D403/04 , A61K31/506 , A61K45/06
摘要: The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
摘要翻译: 本发明提供式I或II的化合物:其中R1,R1b,R2,R3,R4,R5,R6和R7如本文所定义。 式(I)或(II)的化合物及其药物组合物可用于治疗B-Raf相关疾病。
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公开(公告)号:US08242260B2
公开(公告)日:2012-08-14
申请号:US12862418
申请日:2010-08-24
申请人: Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew , Qiong Zhang
发明人: Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew , Qiong Zhang
IPC分类号: C07D345/00 , C07D239/00 , C07D233/00
CPC分类号: C07D403/04 , A61K31/506 , A61K45/06
摘要: The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
摘要翻译: 本发明提供式I或II的化合物:其中R1,R1b,R2,R3,R4,R5,R6和R7如本文所定义。 式(I)或(II)的化合物及其药物组合物可用于治疗B-Raf相关疾病。
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公开(公告)号:US08563553B2
公开(公告)日:2013-10-22
申请号:US13473230
申请日:2012-05-16
申请人: Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew
发明人: Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew
IPC分类号: A61K31/50
CPC分类号: C07D403/04 , A61K31/506 , A61K45/06
摘要: The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
摘要翻译: 本发明提供式I或II的化合物:其中R1,R1b,R2,R3,R4,R5,R6和R7如本文所定义。 式(I)或(II)的化合物及其药物组合物可用于治疗B-Raf相关疾病。
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公开(公告)号:US20140011825A1
公开(公告)日:2014-01-09
申请号:US14022540
申请日:2013-09-10
申请人: Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew
发明人: Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew
IPC分类号: C07D403/04 , A61K45/06 , A61K31/506
CPC分类号: C07D403/04 , A61K31/506 , A61K45/06
摘要: The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
摘要翻译: 本发明提供式I或II的化合物:其中R1,R1b,R2,R3,R4,R5,R6和R7如本文所定义。 式(I)或(II)的化合物及其药物组合物可用于治疗B-Raf相关疾病。
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公开(公告)号:US20110052578A1
公开(公告)日:2011-03-03
申请号:US12862418
申请日:2010-08-24
申请人: Abran Q. Costales , Shenlin Huang , Jeff (Xianming) Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew
发明人: Abran Q. Costales , Shenlin Huang , Jeff (Xianming) Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew
IPC分类号: A61K39/395 , C07D401/04 , A61K31/506 , A61P35/00 , A61P37/00
CPC分类号: C07D403/04 , A61K31/506 , A61K45/06
摘要: The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
摘要翻译: 本发明提供式I或II的化合物:其中R1,R1b,R2,R3,R4,R5,R6和R7如本文所定义。 式(I)或(II)的化合物及其药物组合物可用于治疗B-Raf相关疾病。
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公开(公告)号:US20120225899A1
公开(公告)日:2012-09-06
申请号:US13473230
申请日:2012-05-16
申请人: Abran Q. Costales , Shenlin Huang , Jeff (Xianming) Jin , Zhuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew , Qiong Zhang
发明人: Abran Q. Costales , Shenlin Huang , Jeff (Xianming) Jin , Zhuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew , Qiong Zhang
IPC分类号: A61K31/506 , A61P35/00
CPC分类号: C07D403/04 , A61K31/506 , A61K45/06
摘要: The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
摘要翻译: 本发明提供式I或II的化合物:其中R1,R1b,R2,R3,R4,R5,R6和R7如本文所定义。 式(I)或(II)的化合物及其药物组合物可用于治疗B-Raf相关疾病。
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公开(公告)号:US20110306625A1
公开(公告)日:2011-12-15
申请号:US12870130
申请日:2010-08-27
申请人: Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
发明人: Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
IPC分类号: A61K31/506 , A61P25/24 , A61P1/08 , C07D401/04 , A61P35/00
CPC分类号: C07D403/04 , A61K9/0053 , A61K31/4184 , A61K31/506 , A61K45/06 , C07D401/14 , C07D405/14 , A61K2300/00
摘要: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
摘要翻译: 本发明提供了一类新颖的化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法,特别是涉及B-Raf异常激活的疾病或病症。
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公开(公告)号:US08501758B2
公开(公告)日:2013-08-06
申请号:US12870130
申请日:2010-08-27
申请人: Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
发明人: Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
IPC分类号: A01N43/54
CPC分类号: C07D403/04 , A61K9/0053 , A61K31/4184 , A61K31/506 , A61K45/06 , C07D401/14 , C07D405/14 , A61K2300/00
摘要: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
摘要翻译: 本发明提供了一类新颖的化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法,特别是涉及B-Raf异常激活的疾病或病症。
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公开(公告)号:US20130296318A1
公开(公告)日:2013-11-07
申请号:US13931111
申请日:2013-06-28
申请人: Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
发明人: Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
IPC分类号: C07D403/04 , C07D401/14 , C07D405/14 , A61K45/06 , A61K31/506
CPC分类号: C07D403/04 , A61K9/0053 , A61K31/4184 , A61K31/506 , A61K45/06 , C07D401/14 , C07D405/14 , A61K2300/00
摘要: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
摘要翻译: 本发明提供了一类新颖的化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法,特别是涉及B-Raf异常激活的疾病或病症。
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公开(公告)号:US20100183564A1
公开(公告)日:2010-07-22
申请号:US12608946
申请日:2009-10-29
申请人: Anthony E. Boitano , Michael Cooke , Shifeng Pan , Peter G. Schultz , John Tellew , Yongqin Wan , Xing Wang
发明人: Anthony E. Boitano , Michael Cooke , Shifeng Pan , Peter G. Schultz , John Tellew , Yongqin Wan , Xing Wang
IPC分类号: A61K35/28 , C07D473/34 , A61K31/52 , A61P35/02 , A61P35/00 , A61P7/06 , A61P37/00 , C12N5/0789 , C12N5/078
CPC分类号: A61K35/28 , A61K9/0019 , A61K31/52 , A61K38/00 , A61K2035/124 , C07D473/16 , C07D473/34 , C07D487/04 , C07D495/04 , C12N5/0647 , C12N2501/38 , C12N2501/60
摘要: The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.
摘要翻译: 本发明涉及用于扩增用于移植的CD34 +细胞数量的化合物和组合物。 本发明还涉及包含扩大的造血干细胞(HSCs)的细胞群及其在自体或同种异体移植中用于治疗遗传性免疫缺陷和自身免疫性疾病和多种造血障碍的患者的细胞群,以重建造血细胞谱系和免疫系统防御。
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