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公开(公告)号:US20200333282A1
公开(公告)日:2020-10-22
申请号:US16840990
申请日:2020-04-06
申请人: AgaMatrix, Inc.
发明人: Ian Harding , Richard Williams , Sridhar Iyengar
IPC分类号: G01N27/327 , C12Q1/00 , G01N27/30
摘要: The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.
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公开(公告)号:US20190113498A1
公开(公告)日:2019-04-18
申请号:US16222683
申请日:2018-12-17
申请人: AgaMatrix, Inc.
发明人: Sridhar Iyengar , Ian Harding , Richard Williams , Kevin Cai
IPC分类号: G01N33/487
摘要: A method for obtaining information encoded on an electrochemical test strip is provided. The test strip has two electrodes disposed within a sample space and the information is encoded on the test strip prior to introduction of liquid sample. The method includes the step of introducing sample to the sample space so that the sample is in contact with the two electrodes within the sample space. In another step a value is determined that is representative of the double layer capacitance of the test strip and/or the equivalent capacitance of the test strip. The determined value is then translated into information reflecting a characteristic of the test strip prior to introduction of sample.
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公开(公告)号:US10168313B2
公开(公告)日:2019-01-01
申请号:US13835672
申请日:2013-03-15
申请人: AgaMatrix, Inc.
发明人: Sridhar Iyengar , Ian Harding , Richard Williams , Kevin Cai
IPC分类号: G01N33/487 , G01N27/327
摘要: A method for obtaining information encoded on an electrochemical test strip is provided. The test strip has two electrodes disposed within a sample space and the information is encoded on the test strip prior to introduction of liquid sample. The method includes the step of introducing sample to the sample space so that the sample is in contact with the two electrodes within the sample space. In another step a value is determined that is representative of the double layer capacitance of the test strip and/or the equivalent capacitance of the test strip. The determined value is then translated into information reflecting a characteristic of the test strip prior to introduction of sample.
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公开(公告)号:US20180231552A1
公开(公告)日:2018-08-16
申请号:US15944148
申请日:2018-04-03
申请人: AgaMatrix, Inc.
发明人: Ian Harding , Sridhar Iyengar , Richard Williams
IPC分类号: G01N33/573 , C12Q1/00 , G01N33/543 , G01N27/416
CPC分类号: G01N33/573 , C12Q1/001 , G01N27/4166 , G01N33/5438 , G01N2333/90 , G01N2333/902
摘要: A method and apparatus for electrochemical detection of analyte in a sample makes use of a binding interaction and relies on the discovery that asymmetric distribution of a redox enzyme between two electrodes that occurs when a redox enzyme-containing reagent is immobilized at the surface of one electrode can be detected as a chemical potential gradient arising from an asymmetry in the distribution of oxidized or reduced redox substrate. This chemical potential gradient can be detected potentiometrically by observing the potential difference between the electrodes in an open circuit, or amperometrically by observing the current flow between the electrodes when the circuit is closed. In both cases, the observation of asymmetry can be done without the application of an external potential or current to the electrodes.
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公开(公告)号:US20160091449A1
公开(公告)日:2016-03-31
申请号:US14964756
申请日:2015-12-10
申请人: AgaMatrix, Inc.
发明人: Sridhar Iyengar , Ian Harding , Charles Boiteau , Colin Butters
IPC分类号: G01N27/327 , G01N33/487 , G01J1/42
CPC分类号: G01N27/3272 , G01J1/42 , G01N21/255 , G01N21/7703 , G01N21/8483 , G01N27/327 , G01N27/3273 , G01N33/48707 , G01N33/48771 , G01N2201/08
摘要: A test strip with an incorporated optical waveguide and deflectors punched through the optical waveguide allows light to exit through a layer of the test strip and be detected by a photo detector. Using light and a photodetector, these uniquely coded strips are identified. The waveguide can be constructed by sandwiching two layers of the test strip around a light transmissible layer. This configuration allows light to be transmitted through the test strip and out the other end, as well as allowing some light to escape the deflector. This light is detected by a photodetector mounted in the analyte test meter. The deflectors may be placed in patterns such that detection of this light indicates certain characteristics of the strip, such as non-counterfeit, regional identification, type of analyte tested, and coding information.
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公开(公告)号:US20150083587A1
公开(公告)日:2015-03-26
申请号:US14473182
申请日:2014-08-29
申请人: AgaMatrix, Inc.
发明人: Ian Harding , Sridhar G. Iyengar , Baoguo Wei , Steven Diamond , Martin Forest
IPC分类号: G01N27/28
CPC分类号: G01N27/28 , G01N27/3271 , G01N27/3272 , G01N27/3273 , G01N27/403 , G01N33/50
摘要: The ability to switch at will between amperometric measurements and potentiometric measurements provides great flexibility in performing analyses of unknowns. Apparatus and methods can provide such switching to collect data from an electrochemical cell. The cell may contain a reagent disposed to measure glucose in human blood.
摘要翻译: 在电流测量和电位测量之间切换的能力在执行未知数的分析方面提供了极大的灵活性。 装置和方法可以提供这种切换以从电化学电池收集数据。 细胞可以含有用于测量人血液中的葡萄糖的试剂。
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公开(公告)号:US20140262828A1
公开(公告)日:2014-09-18
申请号:US13835672
申请日:2013-03-15
申请人: AgaMatrix, Inc.
发明人: Sridhar Iyengar , Ian Harding , Richard Williams , Kevin Cai
IPC分类号: G01N27/327
CPC分类号: G01N33/48771 , G01N27/3274
摘要: A method for obtaining information encoded on an electrochemical test strip is provided. The test strip has two electrodes disposed within a sample space and the information is encoded on the test strip prior to introduction of liquid sample. The method includes the step of introducing sample to the sample space so that the sample is in contact with the two electrodes within the sample space. In another step a value is determined that is representative of the double layer capacitance of the test strip and/or the equivalent capacitance of the test strip. The determined value is then translated into information reflecting a characteristic of the test strip prior to introduction of sample.
摘要翻译: 提供了一种用于获得编码在电化学测试条上的信息的方法。 测试条具有设置在样品空间内的两个电极,并且在引入液体样品之前将该信息编码在测试条上。 该方法包括将样品引入样品空间以使样品与样品空间内的两个电极接触的步骤。 在另一步骤中,确定代表测试条的双层电容和/或测试条的等效电容的值。 然后将确定的值转换为在引入样品之前反映测试条的特性的信息。
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公开(公告)号:US20140048425A1
公开(公告)日:2014-02-20
申请号:US13970117
申请日:2013-08-19
申请人: AgaMatrix, Inc.
发明人: Sridhar G. Iyengar , Ian Harding
IPC分类号: G01N27/416
CPC分类号: G01N27/26 , A61B5/14532 , A61B5/1486 , A61B5/1495 , C12Q1/001 , C12Q1/004 , C12Q1/006 , G01N27/3274 , G01N27/4168
摘要: The presence of a select analyte in the sample is evaluated in an an electrochemical system using a conduction cell-type apparatus. A potential or current is generated between the two electrodes of the cell sufficient to bring about oxidation or reduction of the analyte or of a mediator in an analyte-detection redox system, thereby forming a chemical potential gradient of the analyte or mediator between the two electrodes After the gradient is established, the applied potential or current is discontinued and an analyte-independent signal is obtained from the relaxation of the chemical potential gradient. The analyte-independent signal is used to correct the analyte-dependent signal obtained during application of the potential or current. This correction allows an improved measurement of analyte concentration because it corrects for device-specific and test specific factors such as transport (mobility) of analyte and/or mediator, effective electrode area, and electrode spacing (and as a result, sample volume), without need for separate calibration values. The analysis can be performed using disposable test strips in a hand held meter, for example for glucose testing.
摘要翻译: 在使用导电细胞型装置的电化学系统中评价样品中选择的分析物的存在。 在电池的两个电极之间产生电势或电流,足以使分析物或分析物检测氧化还原系统中的介质发生氧化或还原,由此形成两个电极之间的分析物或介体的化学势梯度 梯度建立后,中止施加的电位或电流,并从化学势梯度的弛豫中获得与分析物无关的信号。 分析物独立信号用于校正在施加电位或电流期间获得的分析物依赖信号。 这种校正允许改进分析物浓度的测量,因为它校正了器件特异性和测试特定因素,例如分析物和/或介体的传输(迁移率),有效电极面积和电极间距(以及结果,样品体积), 不需要单独的校准值。 可以使用手持式仪表中的一次性测试条进行分析,例如进行葡萄糖测试。
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公开(公告)号:US11408849B2
公开(公告)日:2022-08-09
申请号:US16840990
申请日:2020-04-06
申请人: AgaMatrix, Inc.
发明人: Ian Harding , Richard Williams , Sridhar Iyengar
IPC分类号: G01N27/327 , C12Q1/00 , G01N27/30
摘要: The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.
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公开(公告)号:US09939440B2
公开(公告)日:2018-04-10
申请号:US15017787
申请日:2016-02-08
申请人: AgaMatrix, Inc.
发明人: Ian Harding , Sridhar Iyengar , Richard Williams
IPC分类号: G01N27/416 , G01N33/573 , C12Q1/00 , G01N33/543
CPC分类号: G01N33/573 , C12Q1/001 , G01N27/4166 , G01N33/5438 , G01N2333/90 , G01N2333/902
摘要: A method and apparatus for electrochemical detection of analyte in a sample makes use of a binding interaction and relies on the discovery that asymmetric distribution of a redox enzyme between two electrodes that occurs when a redox enzyme-containing reagent is immobilized at the surface of one electrode can be detected as a chemical potential gradient arising from an asymmetry in the distribution of oxidized or reduced redox substrate. This chemical potential gradient can be detected potentiometrically by observing the potential difference between the electrodes in an open circuit, or amperometrically by observing the current flow between the electrodes when the circuit is closed. In both cases, the observation of asymmetry can be done without the application of an external potential or current to the electrodes.
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