公开(公告)号：US10287254B2

公开(公告)日：2019-05-14

申请号：US15338984

申请日：2016-10-31

申请人： AiCuris GmbH & Co. KG

发明人： Welljanne Maertens ,  Christian Schickaneder

IPC分类号： C07C309/29 ,  C07C309/30 ,  C07D239/84 ,  A61K31/517

摘要： The invention relates to besylate and tosylate salts of {8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazolin-4-yl} acetic acid and solvates thereof, to the use thereof in a method of treating and/or preventing virus infections, and to the use thereof to produce drugs for use in treating and/or preventing diseases, in particular use as antiviral agents, in particular against cytomegaloviruses (FIG. 1).

公开(公告)号：US09512085B2

公开(公告)日：2016-12-06

申请号：US14381625

申请日：2013-02-28

申请人： AiCuris GmbH & Co. KG

发明人： Welljanne Maertens ,  Christian Schickaneder

IPC分类号： C07D239/84 ,  C07C309/30 ,  C07C309/29 ,  A61K31/517 ,  A61P31/22

CPC分类号： C07D239/84 ,  C07C309/29 ,  C07C309/30

摘要： The invention relates to besylate and tosylate salts of {8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazolin-4-yl}acetic acid and solvates thereof, to the use thereof in a method of treating and/or preventing virus infections, and to the use thereof to produce drugs for use in treating and/or preventing diseases, in particular use as antiviral agents, in particular against cytomegaloviruses.

公开(公告)号：US20150045371A1

公开(公告)日：2015-02-12

申请号：US14381625

申请日：2013-02-28

申请人： AiCuris GmbH & Co. KG

发明人： Welljanne Maertens ,  Christian Schickaneder

IPC分类号： C07D239/84 ,  C07C309/30 ,  C07C309/29

CPC分类号： C07D239/84 ,  C07C309/29 ,  C07C309/30

摘要： The invention relates to besylate and tosylate salts of {8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazolin-4-yl}acetic acid and solvates thereof, to the use thereof in a method of treating and/or preventing virus infections, and to the use thereof to produce drugs for use in treating and/or preventing diseases, in particular use as antiviral agents, in particular against cytomegaloviruses.

摘要翻译： 本发明涉及{8-氟-2- [4-（3-甲氧基苯基）哌嗪-1-基] -3- [2-甲氧基-5-（三氟甲基）苯基] -3,4-苯并噻喃的苯磺酸盐和甲苯磺酸盐， 二氢喹唑啉-4-基}乙酸及其溶剂化物，用于治疗和/或预防病毒感染的方法及其用途，用于制备用于治疗和/或预防疾病的药物，特别是用作 抗病毒剂，特别是针对巨细胞病毒。