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公开(公告)号：US20110244040A1
公开(公告)日：2011-10-06
申请号：US13063515
申请日：2009-09-15
IPC分类号： A61K9/28 , A61K31/506 , A61K31/4245
CPC分类号： A61K9/282 , A61J3/005 , A61K9/2072 , A61K31/4245 , A61K31/513 , A61K31/553
摘要： A film-coated scored tablet in which the forms of respective parts associated with a score line are optimized so as to more preferably divide the film along the score line is provided.
摘要翻译： 提供了一种薄膜涂抹的刻痕片，其中优化与刻痕线相关联的各部分的形式，以便更优选地沿着刻痕线划分膜。
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公开(公告)号：US08541024B2
公开(公告)日：2013-09-24
申请号：US13063515
申请日：2009-09-15
IPC分类号： A61K9/20
CPC分类号： A61K9/282 , A61J3/005 , A61K9/2072 , A61K31/4245 , A61K31/513 , A61K31/553
摘要： A film-coated scored tablet in which the forms of respective parts associated with a score line are optimized so as to more preferably divide the film along the score line is provided.
摘要翻译： 提供了一种薄膜涂抹的刻痕片，其中优化与刻痕线相关联的各部分的形式，以便更优选地沿着刻痕线划分膜。
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公开(公告)号：US08623405B2
公开(公告)日：2014-01-07
申请号：US11795734
申请日：2006-01-27
CPC分类号： A61K9/146 , A23L33/10 , A61K9/145 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K31/405 , A61K31/422 , A61K31/4422 , A61K31/64
摘要： The disclosed method involves preparation of a composition containing a poorly water soluble substance. The composition has a median diameter of not more than 1 μm, and includes (i) a poorly water soluble substance, (ii) polyvinylpyrrolidone or a vinylpyrrolidone-vinyl acetate copolymer, and (iii) an auxiliary dispersion stabilizer. By employing such constitution, a poorly water soluble substance is sufficiently micronized and a composition containing a poorly water soluble substance showing good absorbability of the poorly water soluble substance can be provided.
摘要翻译： 所公开的方法涉及制备含有水难溶性物质的组合物。 该组合物的中值粒径不大于1um，并且包括（i）水难溶性物质，（ii）聚乙烯吡咯烷酮或乙烯基吡咯烷酮 - 乙酸乙烯酯共聚物，和（iii）辅助分散稳定剂。 通过采用这种结构，水溶性差的物质被充分微粉化，并且可以提供含有水难溶性物质显示良好吸收性的难溶于水的物质的组合物。
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公开(公告)号：US20080118552A1
公开(公告)日：2008-05-22
申请号：US11795734
申请日：2006-01-27
CPC分类号： A61K9/146 , A23L33/10 , A61K9/145 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K31/405 , A61K31/422 , A61K31/4422 , A61K31/64
摘要： A composition containing a poorly water soluble substance of the present invention is a composition having a median diameter of not more than 1 μm, comprising (i) a poorly water soluble substance and (ii) polyvinylpyrrolidone or a vinylpyrrolidone-vinyl acetate copolymer, and preferably, a composition having a median diameter of not more than 1 μm, comprising (i) a poorly water soluble substance, (ii) polyvinylpyrrolidone or a vinylpyrrolidone-vinyl acetate copolymer and (iii) an auxiliary dispersion stabilizer. By employing such constitution, a poorly water soluble substance is sufficiently micronized and a composition containing a poorly water soluble substance showing good absorbability of the poorly water soluble substance can be provided.A composition containing a poorly water soluble substance of the present invention can be prepared into a solid dosage form for oral administration in various forms such as tablet, powder, granule, capsule and the like. Therefore, using a composition containing a poorly water soluble substance of the present invention, for example, pharmaceutical preparations in various dosage forms showing good absorbability of a drug, which is a poorly water soluble substance, can be realized.
摘要翻译： 含有本发明的水溶性差的物质的组合物是中值粒径不大于1μm的组合物，其包含（i）水难溶性物质和（ii）聚乙烯吡咯烷酮或乙烯基吡咯烷酮 - 乙酸乙烯酯共聚物，优选 （i）水难溶性物质，（ii）聚乙烯吡咯烷酮或乙烯基吡咯烷酮 - 乙酸乙烯酯共聚物的组合物，和（iii）辅助分散稳定剂。 通过采用这种结构，水溶性差的物质被充分微粉化，并且可以提供含有水难溶性物质显示良好吸收性的难溶于水的物质的组合物。 含有本发明的水溶性差的物质的组合物可以制成固体剂型，用于各种形式的口服给药，例如片剂，粉剂，颗粒剂，胶囊剂等。 因此，使用含有本发明的水溶性差的物质的组合物，例如可以实现作为水难溶性物质的药物的吸收性良好的各种剂型的药物制剂。
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