利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

22 条记录 (耗时 0.023 秒)

    Substituted tetrahydroisoquinoline compounds, and process for producing them, and composition containing them
    2.
    发明授权
    Substituted tetrahydroisoquinoline compounds, and process for producing them, and composition containing them 失效
    取代的四氢异喹啉化合物及其制备方法和含有它们的组合物

    公开(公告)号：US5623074A

    公开(公告)日：1997-04-22

    申请号：US269733

    申请日：1994-06-30

    申请人： Akihiro Tanaka ,  Takashi Fujikura ,  Ryuji Tsuzuki ,  Masaki Yokota ,  Takeyuki Yatsu

    发明人： Akihiro Tanaka ,  Takashi Fujikura ,  Ryuji Tsuzuki ,  Masaki Yokota ,  Takeyuki Yatsu

    IPC分类号： C07D217/16 ,  C07D495/04 ,  C07D513/04

    CPC分类号： C07D495/04 ,  C07D217/16 ,  C07D513/04

    摘要： A compound of the formula (I) or its salt and a process for producing the compounds; The compounds have the effect to dilate neophrovascular tracts; ##STR1## Wherein ##STR2## represents the formula ##STR3## (wherein R.sup.4 is a hydrogen atom or lower alkylsulfonyl); R.sup.1 is hydrogen, lower alkyl, hydroxyl, halogen, amino, or lower acylamino;R.sup.2 is hydrogen, lower alkyl, hydroxyl, amino, or lower alkylsulfonylamino;R.sup.3 is hydrogen, lower alkyl, or hydroxyl;R is hydrogen or halogen;with the proviso that when R.sup.1 is hydroxyl, there is no case that all of R.sup.2, R.sup.3 and R are hydrogens, and further with the proviso that when R is hydrogen, A excludes ##STR4## or a salt thereof.

    摘要翻译： 式（I）化合物或其盐及其制备方法; 该化合物具有扩张新生血管束的作用; 式（IMA）（其中R4是氢原子或低级烷基磺酰基）; R1是氢，低级烷基，羟基，卤素，氨基或低级酰基氨基; R2是氢，低级烷基，羟基，氨基或低级烷基磺酰基氨基; R3是氢，低级烷基或羟基; R是氢或卤素; 条件是当R 1是羟基时，不存在所有的R 2，R 3和R都是氢的情况，并且进一步条件是当R是氢时，A不包括它们或其盐。

    Substituted tetrahydroisoquinoline compounds, and process for producing them, and composition containing them
    5.
    发明授权
    Substituted tetrahydroisoquinoline compounds, and process for producing them, and composition containing them 失效
    取代的四氢异喹啉化合物及其制备方法和含有它们的组合物

    公开(公告)号：US4966904A

    公开(公告)日：1990-10-30

    申请号：US320975

    申请日：1989-03-09

    申请人： Akihiro Tanaka ,  Takashi Fujikura ,  Ryuji Tsuzuki ,  Masaki Yokota ,  Takeyuki Yatsu

    发明人： Akihiro Tanaka ,  Takashi Fujikura ,  Ryuji Tsuzuki ,  Masaki Yokota ,  Takeyuki Yatsu

    IPC分类号： C07D217/16 ,  C07D277/44 ,  C07D495/04 ,  C07D513/04

    CPC分类号： C07D495/04 ,  C07D217/16 ,  C07D513/04

    摘要： A compound of the formula (I) or its salt and a process for producing the compounds; The compounds have the effect to dilate neophrovascular tracts; ##STR1## Wherein ##STR2## represents the formula ##STR3## (wherein R.sup.4 is a hydrogen atom or lower alkylsulfonyl); R.sup.1 is hydrogen, lower alkyl, hydroxyl, halogen, amino, or lower acylamino;R.sup.2 is hydrogen, lower alkyl, hydroxyl, amino, or lower alkylsulfonylamino;R.sup.3 is hydrogen, lower alkyl, or hydroxyl;R is hydrogen or halogen;with the proviso that when R.sup.1 is hydroxyl, there is no case that all of R.sup.2, R.sup.3 and R are hydrogens, and further with the proviso that when R is hydrogen, A excludes ##STR4## or a salt therof.

    摘要翻译： 式（I）化合物或其盐及其制备方法; 该化合物具有扩张新生血管束的作用; （I）其中代表式（IMAGE）（其中R4是氢原子或低级烷基磺酰基）; R1是氢，低级烷基，羟基，卤素，氨基或低级酰基氨基; R2是氢，低级烷基，羟基，氨基或低级烷基磺酰基氨基; R3是氢，低级烷基或羟基; R是氢或卤素; 条件是当R 1是羟基时，不存在所有的R 2，R 3和R都是氢的情况，并且进一步条件是当R是氢时，A不包括囟素或盐。

    Head suspension and method of manufacturing head suspension
    8.
    发明授权
    Head suspension and method of manufacturing head suspension 有权
    头悬挂及制造头悬挂方法

    公开(公告)号：US08390957B2

    公开(公告)日：2013-03-05

    申请号：US12836936

    申请日：2010-07-15

    申请人： Kenichi Takikawa ,  Hideki Fuchino ,  Masaki Yokota

    发明人： Kenichi Takikawa ,  Hideki Fuchino ,  Masaki Yokota

    IPC分类号： G11B5/48 ,  G11B21/16

    CPC分类号： G11B5/4833 ,  Y10T29/49032

    摘要： A head suspension 11 includes a load beam 17 having a base plate 13, a hinge part 15 resiliently supported by the base plate, and a rigid part 14 joined with the hinge part, a reinforcing plate 25 joined with the rigid part at a portion proximal to the hinge part, and a bend 17c on the load beam formed by bending the load beam toward the reinforcing plate along an edge 25a of the reinforcing plate. Only by accurately joining the reinforcing plate with the load beam in a sway direction (a widthwise direction of the head suspension), the load beam is easily and properly bent without torsion to form the bend 17c along the edge of the reinforcing plate that defines a bending strength boundary.

    摘要翻译： 磁头悬架11包括具有基板13的负载梁17，由基板弹性地支撑的铰链部分15和与铰链部分连接的刚性部分14，加强板25与刚性部分接合在近端部分 并且通过沿加强板的边缘25a将负载梁向加强板弯曲而形成的负载梁上的弯曲部17c。 仅通过将加强板与摆动方向（头部悬架的宽度方向）上的加载板精确地接合，则负载梁容易且适当地弯曲而没有扭转，从而沿加强板的边缘形成弯曲部17c，该加强板限定 弯曲强度边界。

    2-phenylthiophene derivative
    10.
    发明授权
    2-phenylthiophene derivative 失效
    2-苯基噻吩衍生物

    公开(公告)号：US07612108B2

    公开(公告)日：2009-11-03

    申请号：US11661294

    申请日：2005-08-26

    申请人： Junji Miyata ,  Masaki Yokota ,  Ryo Naito ,  Akio Kamikawa ,  Masakatsu Kawakami ,  Kazuyuki Hattori

    发明人： Junji Miyata ,  Masaki Yokota ,  Ryo Naito ,  Akio Kamikawa ,  Masakatsu Kawakami ,  Kazuyuki Hattori

    IPC分类号： A61K31/381 ,  C07D333/16

    CPC分类号： C07D333/40 ,  C07D409/04 ,  C07D409/10 ,  C07D417/10 ,  C07D417/12

    摘要： The present invention relates to a 2-phenylthiophene derivative or a salt thereof, wherein the thiophene ring is substituted with a carboxyl group or the like and the benzene ring has an electron-withdrawing group such as a cyano group and an electron-donating group such as a substituted alkoxy group at the same time. Since the compound of the invention has good xanthine oxidase-inhibitory action and uric acid-lowering action and does not have a structure derived from nucleic acid, the compound has advantages of high safety and excellent effects as compared with conventional compounds and is useful as a therapeutic or preventive agent for hyperuricemia, gout, inflammatory bowel diseases, diabetic kidney diseases, diabetic retinopathy, or the like.

    摘要翻译： 本发明涉及2-苯基噻吩衍生物或其盐，其中噻吩环被羧基等取代，苯环具有吸电子基如氰基和给电子基团，例如 作为取代的烷氧基。 由于本发明的化合物具有良好的黄嘌呤氧化酶抑制作用和尿酸降低作用，并且不具有衍生自核酸的结构，与常规化合物相比，该化合物具有安全性高，效果优异的优点，可用作 高尿酸血症，痛风，炎性肠病，糖尿病性肾病，糖尿病性视网膜病变等的治疗或预防剂。