公开(公告)号：US5182702A

公开(公告)日：1993-01-26

申请号：US633612

申请日：1990-12-24

申请人： Akinori Hiramatsu ,  Futoshi Okamoto ,  Hiroshi Kido ,  Hiroyuki Sako ,  Yukio Yamanaka ,  Koji Yamada

发明人： Akinori Hiramatsu ,  Futoshi Okamoto ,  Hiroshi Kido ,  Hiroyuki Sako ,  Yukio Yamanaka ,  Koji Yamada

IPC分类号： H02M1/00 ,  H02M1/42 ,  H02M3/338 ,  H05B41/28

CPC分类号： H02M1/425 ,  H02M3/3387 ,  H05B41/28 ,  Y02B70/126 ,  Y10S315/07

摘要： An inverter device has a full-wave rectifier providing a pulsating DC voltage from an input AC voltage, a smoothing circuit. The smoothing circuit includes a choke coil, a smoothing capacitor and a switching element chopping the pulsating DC voltage through the choke coil into a smoothed DC voltage at the smoothing capacitor. An inverter is included to have the element common to the smoothing circuit and operating to switch the smoothed DC voltage to apply a resulting voltage to a load circuit including a load, inductance and capacitor. The inductance and capacitor define an oscillation circuit providing to the load an oscillating current composed of first and second currents of opposite directions. The oscillating current alternating to flow for a nominal on-time duration determined by a circuit constant of the oscillation circuit itself. A controller is included to detect the termination of the second current and excites the common switching element at a timing dependent upon the termination of the second current so as to start flowing the first current. The controller includes a timer for separately controlling an actual on-time duration for flowing the first current within the nominal on-time duration, whereby enabling to regulate the accumulated DC voltage in the smoothing capacitor at a desired level by controlling to vary the actual on-time duration of the common switching element.

公开(公告)号：US20130045232A1

公开(公告)日：2013-02-21

申请号：US13582160

申请日：2011-03-01

申请人： Hiroshi Kido ,  Dai Mizuno

发明人： Hiroshi Kido ,  Dai Mizuno

IPC分类号： A61K39/39 ,  A61P37/04 ,  A61P37/08 ,  A61K39/35

CPC分类号： C07K14/005 ,  A61K9/0043 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K47/32 ,  A61K2039/541 ,  A61K2039/543 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55561 ,  C12N2760/16122 ,  C12N2760/16134 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/396 ,  Y02A50/466

摘要： A mucosal vaccine producing an antigen-specific mucosal IgA and a blood IgG in the levels capable of exerting an effective immune induction and an infection-preventing effect, which comprises: (a) an AD vehicle consisting of a synthetic peptide and a lipid(s), wherein the synthetic peptide consisting of the amino acid sequence KnLm (wherein n is 4 to 8 and m is 11 to 20); (b) a carboxylvinyl polymer; and, (c) an antigenic protein, in an amount incapable of producing a sufficient mucosal IgA and blood IgG for exerting an effective immune induction and an infection-preventing effect when used by itself. The mucosal vaccine of the invention has an antibody producing ability which is more potent than those of mucosal vaccines of the prior art, and as a result it can exert an excellent effect even with an extremely small amount of an antigen.

摘要翻译： 一种在能够发挥有效免疫诱导和感染预防作用的水平中产生抗原特异性粘膜IgA和血液IgG的粘膜疫苗，其包括：（a）由合成肽和脂质组成的AD载体 ），其中由氨基酸序列KnLm（其中n为4至8且m为11至20）组成的合成肽; （b）羧基乙烯基聚合物; 和（c）抗原性蛋白质，其量不足以产生足够的粘膜IgA和血液IgG，用于在自身使用时发挥有效的免疫诱导和感染预防作用。 本发明的粘膜疫苗具有比现有技术的粘膜疫苗更有效的抗体生成能力，结果即使使用极少量的抗原也能发挥优异的效果。

公开(公告)号：US20110234104A1

公开(公告)日：2011-09-29

申请号：US13071762

申请日：2011-03-25

申请人： Masanori MISHIMA ,  Hiroshi Kido ,  Shohei Yamamoto ,  Masanao Okawa ,  Hirofumi Konishi ,  Katunobu Hamamoto

发明人： Masanori MISHIMA ,  Hiroshi Kido ,  Shohei Yamamoto ,  Masanao Okawa ,  Hirofumi Konishi ,  Katunobu Hamamoto

IPC分类号： H01J7/42

CPC分类号： H05B33/0848 ,  H05B33/08 ,  H05B33/0896 ,  Y02B20/32

摘要： An illumination load determination device includes an illumination load; a voltage applying unit for applying a voltage to the illumination load; a connection unit for connecting the illumination load and the voltage applying unit; a detection unit for detecting at least one of a current flowing through the illumination load and a voltage across the illumination load when the voltage is applied to the illumination load from the voltage applying unit via the connection unit; and a determination unit for determining a type of the illumination load based on an output from the detection unit. The determination unit has a comparator for comparing a detection value detected by the detection unit to a predetermined threshold, and determines that the illumination load has a capacitance based on an output of the comparator. The voltage applying unit lights on the determined illumination load with a rated driving voltage.

摘要翻译： 照明负载确定装置包括照明负载; 电压施加单元，用于向照明负载施加电压; 用于连接照明负载和电压施加单元的连接单元; 检测单元，用于当电压经由连接单元从电压施加单元施加到照明负载时，检测流过照明负载的电流和照明负载两端的电压中的至少一个; 以及确定单元，用于基于来自检测单元的输出来确定照明负载的类型。 确定单元具有用于将由检测单元检测的检测值与预定阈值进行比较的比较器，并且基于比较器的输出确定照明负载具有电容。 电压施加单元以额定驱动电压对确定的照明负载点亮。

公开(公告)号：US07772783B2

公开(公告)日：2010-08-10

申请号：US12067287

申请日：2005-09-28

申请人： Shinji Makimura ,  Hiroshi Kido

发明人： Shinji Makimura ,  Hiroshi Kido

IPC分类号： H05B41/24

CPC分类号： H05B41/2806 ,  H05B41/3925 ,  Y02B20/22 ,  Y10S315/04

摘要： A dimmable electronic ballast for an electrodeless discharge lamp comprises an inverter circuit, a resonance circuit, an induction coil and a start circuit. The start circuit has a variable time constant. The start circuit sweeps a drive frequency of the inverter circuit through a time constant for start or restart so that the voltage applied across the coil is raised from voltage lower than start voltage and restart voltage for starting and restarting the lamp to voltage higher than the start voltage and the restart voltage. The time constant for start during a start period for starting the lamp is larger than the time constant for restart during a restart period for restarting the lamp.

摘要翻译： 一种无电极放电灯的可调光电子镇流器包括逆变器电路，谐振电路，感应线圈和启动电路。 启动电路具有可变时间常数。 启动电路通过时间常数扫描逆变器电路的驱动频率，以启动或重新启动，使得施加在线圈上的电压从低于启动电压的电压升高，并将启动和重新启动灯的电压重新启动到高于启动的电压 电压和重启电压。 启动灯的启动期间启动的时间常数大于重新启动灯的重启期间的重启时间常数。

公开(公告)号：US20100062454A1

公开(公告)日：2010-03-11

申请号：US12461983

申请日：2009-08-31

申请人： Hiroshi Kido ,  Kaoru Terashima

发明人： Hiroshi Kido ,  Kaoru Terashima

IPC分类号： G01N33/53

CPC分类号： G01N33/6854 ,  G01N33/56983 ,  G01N33/582 ,  G01N2333/11 ,  G01N2800/50

摘要： An object of the present invention is to provide a method for predicting the risk of acquiring influenza, which is characterized by low price, low invasiveness, and applicability to total automation. The present invention provides a method for predicting the risk of acquiring influenza, which comprises measuring the ratio of anti-influenza IgA to the total IgA in a specimen collected from a subject.

摘要翻译： 本发明的目的是提供一种用于预测感冒风险的方法，其特征在于价格低廉，侵入性低，适用于全自动化。 本发明提供了一种预测获得流感的风险的方法，其包括测量从受试者收集的样本中抗流感IgA与总IgA的比例。

公开(公告)号：US20090322239A1

公开(公告)日：2009-12-31

申请号：US12457864

申请日：2009-06-24

申请人： Akira Nakajo ,  Hiroshi Kido ,  Shinji Makimura

发明人： Akira Nakajo ,  Hiroshi Kido ,  Shinji Makimura

IPC分类号： H05B41/24

CPC分类号： H05B41/2806 ,  Y02B20/22

摘要： An induction lamp lighting device includes an induction coil arranged adjacent to an induction lamp; a direct current power supply circuit for outputting a direct current voltage; a high-frequency power supply circuit for converting the direct current voltage to an alternating current voltage and supplying the alternating current voltage to the induction coil; and a control circuit for controlling the direct current power supply circuit and the high-frequency power supply circuit. The control circuit performs a startup preparation operation by which to control the high-frequency power supply circuit so that, immediately after the alternating current voltage begins to be outputted from the high-frequency power supply circuit to the induction coil, the alternating current voltage is gradually increased to such a voltage value as not to generate arc discharge in the induction lamp and then kept at the voltage value for a specified time.

摘要翻译： 感应灯照明装置包括：与感应灯相邻布置的感应线圈; 用于输出直流电压的直流电源电路; 高频电源电路，用于将直流电压转换成交流电压，并将交流电压提供给感应线圈; 以及用于控制直流电源电路和高频电源电路的控制电路。 控制电路进行启动准备操作，通过该操作来控制高频电源电路，使得在交流电压开始从高频电源电路输出到感应线圈之后，交流电压为 逐渐增加到不会在感应灯中产生电弧放电的电压值，然后在一定时间内保持在电压值。

公开(公告)号：US20090130131A1

公开(公告)日：2009-05-21

申请号：US11990001

申请日：2006-08-04

申请人： Hiroshi Kido ,  Dai Mizuno

发明人： Hiroshi Kido ,  Dai Mizuno

IPC分类号： A61K39/385

CPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K39/35 ,  A61K39/385 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/5252 ,  A61K2039/541 ,  A61K2039/542 ,  A61K2039/543 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/6031 ,  C07K14/47 ,  C12N2760/16134

摘要： In the aim of practical utilization of a safe and effective transnasal/inactivated/mucosal vaccine and establishment of a technology for imparting capacity of producing both of IgA and IgG antibodies to a conventional inactivated vaccine, toxoid; allergen, or the like, a means for prevention and treatment of allergy, and the like, it is intended to provide an antigen-drug vehicle (AD vehicle) enabling transnasal, transmucosal, and transdermal administrations, an inactivated vaccine simultaneously inducing a mucosal immunity and humoral immunity by using the AD vehicle, a production method of the inactivated vaccine, an AD vehicle enabling a switch from induction of selective production of IgA antibody to induction of both of IgA and IgG antibodies, and a transnasal vaccine, a mucosal vaccine, a therapeutic/prophylactic agent for allergy, and the like using the AD vehicle.

摘要翻译： 为了实际应用安全有效的经鼻/灭活/粘膜疫苗和建立一种赋予常规灭活疫苗，类毒素的IgA和IgG抗体产生能力的技术的目的。 过敏原等，预防和治疗过敏等的手段，旨在提供能够经鼻，经粘膜和透皮给药的抗原药物载体（AD载体），同时诱导粘膜免疫的灭活疫苗 和使用AD载体的体液免疫，灭活疫苗的制备方法，能够从诱导选择性产生IgA抗体转变成诱导IgA和IgG抗体两者的AD载体，以及经鼻疫苗，粘膜疫苗， 使用AD载体的用于过敏的治疗/预防剂等。

公开(公告)号：US07339329B2

公开(公告)日：2008-03-04

申请号：US10544720

申请日：2003-11-21

申请人： Shinji Makimura ,  Hiroshi Kido ,  Shingo Masumoto ,  Yuji Kumagai ,  Akira Nakajo

发明人： Shinji Makimura ,  Hiroshi Kido ,  Shingo Masumoto ,  Yuji Kumagai ,  Akira Nakajo

IPC分类号： H05B41/24

CPC分类号： H05B41/2806 ,  H05B41/3925 ,  H05B41/3927 ,  Y02B20/22 ,  Y10S315/04

摘要： A ballast for an electrodeless discharge lamp includes a high frequency power supply that supplies a high frequency electric power to an induction coil for operating the lamp. A dimmer controller generates a control signal in response to a dimmer command designating a varying dimming ratio. The control signal defines a first period Ton in which the power supply is controlled to apply a coil voltage of a first level V1 to the induction coil for operating the lamp. The first period is followed by a second period Toff in which the power supply is controlled to apply the coil voltage of a second level V2 that is lower than the first level and fails to sustain the lamp. The control signal defines, between the second period and the first period, a starting period Tst in which the coil voltage increases continuously for smooth transition from an off-condition to an on-condition of the lamp.

摘要翻译： 无电极放电灯的镇流器包括向用于操作灯的感应线圈供给高频电力的高频电源。 调光器控制器响应于指示变化的调光比的调光器命令产生控制信号。 控制信号限定第一时段Ton，其中控制电源以将第一电平V 1的线圈电压施加到用于操作灯的感应线圈。 第一时段之后是第二时段Toff，其中控制电源以施加低于第一电平的第二电平V 2的线圈电压，并且不能维持灯。 控制信号在第二周期和第一周期之间定义起始周期Tst，其中线圈电压连续增加以从灯的关闭状态到状态的平滑过渡。

公开(公告)号：US20070141073A1

公开(公告)日：2007-06-21

申请号：US11547650

申请日：2005-03-22

申请人： Hiroshi Kido ,  Dai Mizuno

发明人： Hiroshi Kido ,  Dai Mizuno

IPC分类号： A61K39/00

CPC分类号： A61K39/00 ,  A61K2039/541

摘要： Disclosed are an antigen-drug vehicle (AD vehicle) exerting a function of inducing the preferential and selective production of an antigen-specific secretory IgA antibody, local immunity or mucosal immunity; a method of inducing mucosal immunity, a mucosal vaccine and a preventive or a remedy for allergy using the above AD vehicle; and a transmucosal or transdermal DDS using the above vehicle.

摘要翻译： 公开了具有诱导抗原特异性分泌型IgA抗体的优先选择性产生的功能的抗原 - 药物载体（AD载体），局部免疫或粘膜免疫; 使用上述AD载体诱导粘膜免疫的方法，粘膜疫苗和用于过敏的预防或补救措施; 和使用上述载体的经粘膜或透皮DDS。

公开(公告)号：US06388122B1

公开(公告)日：2002-05-14

申请号：US09155868

申请日：1998-10-07

申请人： Hiroshi Kido ,  Hisao Nakai

发明人： Hiroshi Kido ,  Hisao Nakai

IPC分类号： C07C22938

CPC分类号： C07D211/62 ,  A61K31/222 ,  A61K31/24 ,  A61K31/245 ,  A61K31/40 ,  A61K31/401 ,  A61K31/445 ,  A61K31/495 ,  C07C257/18 ,  C07C279/14 ,  C07C279/18 ,  C07C311/16 ,  C07C323/59 ,  C07D207/16 ,  C07D211/60

摘要： A tryptase inhibitor comprising as an active ingredient at least one member selected from among guanidinoaliphatic acid derivatives of the formula (I), guanidinobenzoic acid derivatives of the formula (II), guanidinophenol derivatives of the formula (III), amidinophenol derivatives of the formula (IV), and novel guanidinophenol derivatives of the formula (V) (in the formulae, Gu is guanidino).

摘要翻译： 一种类胰蛋白酶抑制剂，其包含选自式（I）的胍基脂肪酸衍生物，式（II）的胍基苯甲酸衍生物，式（III）的胍基苯酚衍生物，式（III）的脒基苯酚衍生物， IV）和式（V）的新型胍基苯酚衍生物（在式中，Gu是胍基）。