Preparation of Aminopyrimidine Compounds
    1.
    发明申请
    Preparation of Aminopyrimidine Compounds 有权
    氨基嘧啶化合物的制备

    公开(公告)号:US20080058520A1

    公开(公告)日:2008-03-06

    申请号:US11933626

    申请日:2007-11-01

    IPC分类号: C07D239/36

    摘要: A 2-(N-methyl-N-methanesulfonylamino)pyrimidine compound of the formula (3): [R is a hydrocarbyl group], is prepared by the steps of: (I) reacting an isobutyrylacetate ester with 4-fluorobenzaldehyde and urea in the presence of a protonic compound and a metal salt; (II) oxidizing the reaction product of the step (I); (III) reacting the oxidation product of the step (II) with an organic sulfonyl halide or an organic sulfonyl anhydride; and (IV) reacting the reaction product of the step (III) with N-methyl-N-methanesulfonamide.

    摘要翻译: 通过以下步骤制备式(3)的2-(N-甲基-N-甲磺酰基氨基)嘧啶化合物:[R是烃基]:(I)使异丁酰乙酸酯与4-氟苯甲醛和尿素反应 质子化合物和金属盐的存在; (II)氧化步骤(I)的反应产物; (III)使步骤(II)的氧化产物与有机磺酰卤或有机磺酰酐反应; 和(IV)使步骤(III)的反应产物与N-甲基-N-甲磺酰胺反应。