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    Process for the preparation of HMG-COA reductase inhibitors
    4.
    发明授权
    Process for the preparation of HMG-COA reductase inhibitors 有权
    制备HMG-COA还原酶抑制剂的方法

    公开(公告)号：US06245535B1

    公开(公告)日：2001-06-12

    申请号：US09463912

    申请日：2000-02-02

    申请人： Yutaka Takano ,  Masaru Hasegawa ,  Hideo Mori ,  Katsuhiko Ando ,  Keiko Ochiai ,  Hiroaki Motoyama ,  Akio Ozaki

    发明人： Yutaka Takano ,  Masaru Hasegawa ,  Hideo Mori ,  Katsuhiko Ando ,  Keiko Ochiai ,  Hiroaki Motoyama ,  Akio Ozaki

    IPC分类号： C12P762

    CPC分类号： C12R1/07 ,  C12P7/62 ,  C12P17/06

    摘要： Disclosed is a process for producing a compound represented by general formula (II-a): (wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (II-a)] or the lactone form of Compound (II-a) [hereinafter referred to as Compound (II-b)] which comprises subjecting a compound represented by general formula (I-a): (wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (I-a)] or the lactone form of Compound (I-a) [hereinafter referred to as Compound (I-b)] to the action of an enzyme source derived from a microorganism belonging to the genus Bacillus and capable of converting Compound (I-a) or Compound (I-b) into Compound (II-a) or Compound (II-b) in a reaction mixture to form Compound (II-a) or Compound (II-b) in the reaction mixture, and recovering Compound (II-a) or Compound (II-b) from the reaction mixture.

    摘要翻译： 公开了一种制备由通式（II-a）表示的化合物的方法：其中R 1表示氢原子，取代或未取代的烷基或碱金属; R 2表示取代或未取代的烷基或芳基） [化学式（II-a）]或化合物（II-a）的内酯形式[以下称为化合物（II-b）]] [其中包括使通式（Ia）表示的化合物 R1表示氢原子，取代或未取代的烷基或碱金属; R2表示取代或未取代的烷基或芳基）[以下称为化合物（Ia）]或化合物（Ia）的内酯形式[ （Ia）或化合物（Ib）转化为化合物（II-a）或化合物（II-a）的酶源的作用，以下称为化合物（Ib） b）在反应混合物中形成化合物（II -a）或化合物（II-b），并从反应混合物中回收化合物（II-a）或化合物（II-b）。

    Process for producing cis-3-hydroxy-L-proline
    5.
    发明授权
    Process for producing cis-3-hydroxy-L-proline 失效
    顺式-3-羟基-L-脯氨酸的制备方法

    公开(公告)号：US5962292A

    公开(公告)日：1999-10-05

    申请号：US708856

    申请日：1996-09-09

    申请人： Akio Ozaki ,  Hideo Mori ,  Takeshi Shibasaki ,  Katsuhiko Ando ,  Keiko Ochiai ,  Shigeru Chiba ,  Yoichi Uosaki

    发明人： Akio Ozaki ,  Hideo Mori ,  Takeshi Shibasaki ,  Katsuhiko Ando ,  Keiko Ochiai ,  Shigeru Chiba ,  Yoichi Uosaki

    IPC分类号： C12N9/02 ,  C12P13/24 ,  C07H21/04 ,  C12N1/20 ,  C12N15/00

    CPC分类号： C12N9/0071 ,  C12P13/24 ,  C12Y114/11002 ,  Y10S435/814

    摘要： An industrially applicable process for producing cis-3-hydroxy-L-proline, which is useful as a raw material for medicines or as an additive to foods. In the process, L-proline is converted into cis-3-hydroxy-L-proline in the presence of an enzyme source which is derived from a microorganism belonging to the genus Streptomyces or Bacillus and which catalyzes hydroxylation of L-proline into cis-3-hydroxy-L-proline, a divalent iron ion and 2-ketoglutaric acid, in an aqueous medium, and the produced cis-3-hydroxy-L-proline is collected from the aqueous medium. A novel enzyme L-proline-3-hydroxylase, a gene of L-proline-3-hydroxylase which is useful for the process, a transformant containing the gene, and a process for producing L-proline-3-hydroxylase using the transformant.

    摘要翻译： 用于生产顺式-3-羟基-L-脯氨酸的工业上适用的方法，其可用作药物的原料或作为食品添加剂。 在此过程中，L-脯氨酸在衍生自属于链霉菌属或芽孢杆菌属的微生物的酶源存在下转化为顺式-3-羟基-L-脯氨酸，其催化L-脯氨酸的羟基化为顺式 - 3-羟基-L-脯氨酸，二价铁离子和2-酮戊二酸，在水性介质中收集生成的顺式-3-羟基-L-脯氨酸。 一种新的L-脯氨酸-3-羟化酶，可用于该方法的L-脯氨酸-3-羟化酶的基因，含该基因的转化体，以及使用转化体产生L-脯氨酸-3-羟化酶的方法。

    Desensitized aspartokinase
    6.
    发明授权
    Desensitized aspartokinase 有权
    脱敏天冬氨酸激酶

    公开(公告)号：US06893848B1

    公开(公告)日：2005-05-17

    申请号：US09958606

    申请日：2000-04-14

    申请人： Haruhiko Yokoi ,  Junko Ohnishi ,  Keiko Ochiai ,  Yoshiyuki Yonetani ,  Akio Ozaki

    发明人： Haruhiko Yokoi ,  Junko Ohnishi ,  Keiko Ochiai ,  Yoshiyuki Yonetani ,  Akio Ozaki

    IPC分类号： C12N1/19 ,  C12N9/12 ,  C12P13/08 ,  C07C229/00 ,  C12N1/20 ,  C12N15/63 ,  C12N15/74 ,  C07N21/04

    CPC分类号： C12N9/1217 ,  C12P13/08

    摘要： The present invention relates to a novel aspartokinase derived from a Coryneform bacterium; a DNA encoding the enzyme; a recombinant DNA containing the above DNA; a Coryneform bacterium having the above recombinant DNA or a Coryneform bacterium having the DNA on its chromosome; and a process for producing L-lysine by culturing the above microorganism. Construction has been successfully made of a DNA encoding an aspartokinase freed from concerted feedback inhibition by L-lysine and L-threonine derived from a Corynebacterium and has a nucleotide sequence encoding an amino acid sequence wherein the amino acid residue at position 311 is an amino acid other than Thr in the amino acid sequence shown by SEQ ID NO: 18.

    摘要翻译： 本发明涉及一种衍生自棒状杆菌属细菌的新型天冬氨酸激酶; 编码酶的DNA; 含有上述DNA的重组DNA; 具有上述重组DNA的棒状细菌或其染色体上具有DNA的棒状细菌; 以及通过培养上述微生物来生产L-赖氨酸的方法。 已经成功制备了编码天冬氨酸的DNA，其不含由L-赖氨酸和由棒状杆菌衍生的L-苏氨酸的协同反馈抑制，并且具有编码氨基酸序列的核苷酸序列，其中311位的氨基酸残基是氨基酸 SEQ ID NO：18所示的氨基酸序列中的Thr除外。

    Bacillus strains which produce HMG-CoA reductase inhibitors
    7.
    发明授权
    Bacillus strains which produce HMG-CoA reductase inhibitors 有权
    产生HMG-CoA还原酶抑制剂的芽孢杆菌菌株

    公开(公告)号：US06468780B2

    公开(公告)日：2002-10-22

    申请号：US09829080

    申请日：2001-04-10

    申请人： Yutaka Takano ,  Masaru Hasegawa ,  Hideo Mori ,  Katsuhiko Ando ,  Keiko Ochiai ,  Hiroaki Motoyama ,  Akio Ozaki

    发明人： Yutaka Takano ,  Masaru Hasegawa ,  Hideo Mori ,  Katsuhiko Ando ,  Keiko Ochiai ,  Hiroaki Motoyama ,  Akio Ozaki

    IPC分类号： C12N120

    CPC分类号： C12R1/07 ,  C12P7/62 ,  C12P17/06

    摘要： Disclosed is a process for producing a compound represented by general formula (II-a): (wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (II-a)] or the lactone form of Compound (II-a) [hereinafter referred to as Compound (II-b)] which comprises subjecting a compound represented by general formula (I-a): (wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (I-a)] or the lactone form of Compound (I-a) [hereinafter referred to as Compound (I-b)] to the action of an enzyme source derived from a microorganism belonging to the genus Bacillus and capable of converting Compound (I-a) or Compound (I-b) into Compound (II-a) or Compound (II-b) in a reaction mixture to form Compound (II-a) or Compound (II-b) in the reaction mixture, and recovering Compound (II-a) or Compound (II-b) from the reaction mixture.

    摘要翻译： 公开了一种制备由通式（II-a）表示的化合物的方法：其中R 1表示氢原子，取代或未取代的烷基或碱金属; R 2表示取代或未取代的烷基或芳基） [化学式（II-a）]或化合物（II-a）的内酯形式[以下称为化合物（II-b）]] [其中包括使通式（Ia）表示的化合物 R1表示氢原子，取代或未取代的烷基或碱金属; R2表示取代或未取代的烷基或芳基）[以下称为化合物（Ia）]或化合物（Ia）的内酯形式[ （Ia）或化合物（Ib）转化为化合物（II-a）或化合物（II-a）的酶源的作用，以下称为化合物（Ib） b）在反应混合物中形成化合物（II -a）或化合物（II-b），并从反应混合物中回收化合物（II-a）或化合物（II-b）。

    Process for producing CIS-3-hydroxy-L-proline
    8.
    发明授权
    Process for producing CIS-3-hydroxy-L-proline 有权
    制备CIS-3-羟基-L-脯氨酸的方法

    公开(公告)号：US06413748B1

    公开(公告)日：2002-07-02

    申请号：US09455406

    申请日：1999-12-06

    申请人： Akio Ozaki ,  Hideo Mori ,  Takeshi Shibasaki ,  Katsuhiko Ando ,  Keiko Ochiai ,  Shigeru Chiba ,  Yoichi Uosaki

    发明人： Akio Ozaki ,  Hideo Mori ,  Takeshi Shibasaki ,  Katsuhiko Ando ,  Keiko Ochiai ,  Shigeru Chiba ,  Yoichi Uosaki

    IPC分类号： C12P1324

    CPC分类号： C12N9/0071 ,  C12P13/24 ,  C12Y114/11002 ,  Y10S435/814

    摘要： An industrially applicable process for producing cis-3-hydroxy-L-proline, which is useful as a raw material for medicines or as an additive to foods. In the process, L-proline is converted into cis-3-hydroxy-L-proline in the presence of an enzyme source which is derived from a microorganism belonging to the genus Streptomyces or Bacillus and which catalyzes hydroxylation of L-proline into cis-3-hydroxy-L-proline, a divalent iron ion and 2-ketoglutaric acid, in an aqueous medium, and the produced cis-3-hydroxy-L-proline is collected from the aqueous medium. A novel enzyme L-proline-3-hydroxylase, a gene of L-proline-3-hydroxylase which is useful for the process, a transformant containing the gene, and a process for producing L-proline-3-hydroxylase using the transformant.

    摘要翻译： 用于生产顺式-3-羟基-L-脯氨酸的工业上适用的方法，其可用作药物的原料或作为食品添加剂。 在此过程中，L-脯氨酸在衍生自属于链霉菌属或芽孢杆菌属的微生物的酶源存在下转化为顺式-3-羟基-L-脯氨酸，其催化L-脯氨酸的羟基化为顺式 - 3-羟基-L-脯氨酸，二价铁离子和2-酮戊二酸，在水性介质中收集生成的顺式-3-羟基-L-脯氨酸。 一种新的L-脯氨酸-3-羟化酶，可用于该方法的L-脯氨酸-3-羟化酶的基因，含该基因的转化体，以及使用转化体产生L-脯氨酸-3-羟化酶的方法。