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公开(公告)号:US20060264476A1
公开(公告)日:2006-11-23
申请号:US11459745
申请日:2006-07-25
申请人: Akiyo Claiborne , Stephen Gwaltney , Lisa Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert Mantei , Todd Rockway , Hing Sham , Gerard Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
发明人: Akiyo Claiborne , Stephen Gwaltney , Lisa Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert Mantei , Todd Rockway , Hing Sham , Gerard Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
IPC分类号: A61K31/4439 , C07D403/02
CPC分类号: C07D233/64 , C07D401/12 , C07D405/12 , C07D409/12
摘要: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
摘要翻译: 具有下式的取代的咪唑和噻唑可用于抑制法呢基转移酶。 还公开了法呢基转移酶抑制组合物和在患者体内抑制法尼基转移酶的方法。
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公开(公告)号:US20050187246A1
公开(公告)日:2005-08-25
申请号:US11109017
申请日:2005-04-19
申请人: Qun Li , Hing Sham , Keith Woods , Beth Steiner , Stephen Gwaltney , Kenneth Barr , Hovis Imade , Saul Rosenberg
发明人: Qun Li , Hing Sham , Keith Woods , Beth Steiner , Stephen Gwaltney , Kenneth Barr , Hovis Imade , Saul Rosenberg
IPC分类号: A61P43/00 , C07C235/56 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , C07C317/22 , C07C317/28 , C07C323/20 , C07C323/29 , C07D209/04 , C07D209/08 , A61K31/4709 , A61K31/18 , A61K31/405 , A61K31/4184
CPC分类号: C07C323/29 , C07C235/56 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , C07C317/22 , C07C317/28 , C07C323/20 , C07D209/04 , C07D209/08
摘要: Compounds having formula (I) inhibit cellular proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.
摘要翻译: 具有式(I)的化合物抑制细胞增殖。 公开了制备化合物的方法,含有该化合物的药物组合物和使用该化合物的治疗方法。
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公开(公告)号:US20190055212A1
公开(公告)日:2019-02-21
申请号:US16077864
申请日:2017-02-16
申请人: Stephen Gwaltney
发明人: Stephen Gwaltney
IPC分类号: C07D401/04 , A61P35/00 , C07D401/14 , C07D491/113 , C07D405/14 , C07D471/04
摘要: This disclosure relates to compounds that inhibit histone demethylase activity. In particular, the disclosure relates to compounds that inhibit histone lysine demethylase KDM5B, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions disclosed herein.
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公开(公告)号:US20080108808A1
公开(公告)日:2008-05-08
申请号:US11929673
申请日:2007-10-30
申请人: Jun Feng , Stephen Gwaltney , Jeffrey Stafford , Zhiyuan Zhang , Bruce Elder , Paul Isbester , Grant Palmer , Jonathon Salsbury , Luckner Ulysse
发明人: Jun Feng , Stephen Gwaltney , Jeffrey Stafford , Zhiyuan Zhang , Bruce Elder , Paul Isbester , Grant Palmer , Jonathon Salsbury , Luckner Ulysse
IPC分类号: C07D401/04 , C07D401/14 , C07D403/04
CPC分类号: C07D403/04 , C07D239/545 , C07D401/04 , C07D401/14 , C07D403/12 , C07D409/14
摘要: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C═NR9; and each L, X, R1, R2, and R3 are as defined herein.
摘要翻译: 提供化合物,药物,试剂盒和方法用于DPP-IV和其它S9蛋白酶,其包含包含以下的化合物:其中M为N或CR 4; Q 1和Q 2各自独立地选自CO,SO,SO 2和C-NR 9 SUB> 并且每个L,X,R 1,R 2和R 3 3如本文所定义。
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公开(公告)号:US20050065145A1
公开(公告)日:2005-03-24
申请号:US10934326
申请日:2004-09-02
申请人: Sheldon Cao , Jun Feng , Stephen Gwaltney , Stephen Kaldor , Jeffrey Stafford , Michael Wallace , Xiao-Yi Xiao , Zhiyuan Zhang
发明人: Sheldon Cao , Jun Feng , Stephen Gwaltney , Stephen Kaldor , Jeffrey Stafford , Michael Wallace , Xiao-Yi Xiao , Zhiyuan Zhang
IPC分类号: C07D401/04 , A61K31/549 , A61K31/513
CPC分类号: C07D401/04
摘要: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
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公开(公告)号:US20060014764A1
公开(公告)日:2006-01-19
申请号:US11183335
申请日:2005-07-15
申请人: Jun Feng , Stephen Gwaltney , Betty Lam , Zhiyuan Zhang
发明人: Jun Feng , Stephen Gwaltney , Betty Lam , Zhiyuan Zhang
IPC分类号: A61K31/519 , C07D487/02
CPC分类号: C07D471/04 , C07D471/14
摘要: Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: wherein R2 is amino (C1-6)alkyl, hetero(C3-12)cycloakyl, hetero(C4-12)bicycloaryl, heteroaryl, or cyano; and W, X, Y, Z, R1, R5 and R7 are as defined herein.
摘要翻译: 提供化合物,药物组合物,试剂盒和方法用于DPP-IV和其它S9蛋白酶,其包含下式化合物:其中R 2是氨基(C 1-6) 杂(C 3-12-12)环烷基,杂(C 4-14-12)双环芳基,杂芳基或氰基; 且W,X,Y,Z,R 1,R 5和R 7如本文所定义。
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公开(公告)号:US20050070531A1
公开(公告)日:2005-03-31
申请号:US10918186
申请日:2004-08-12
申请人: Jun Feng , Stephen Gwaltney , Stephen Kaldor , Jeffrey Stafford , Michael Wallace , Zhiyuan Zhang
发明人: Jun Feng , Stephen Gwaltney , Stephen Kaldor , Jeffrey Stafford , Michael Wallace , Zhiyuan Zhang
IPC分类号: A61K9/08 , A61K9/20 , A61K31/506 , A61P3/10 , A61P7/00 , A61P13/12 , A61P17/06 , A61P19/00 , A61P19/02 , A61P25/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D239/02 , C07D239/36 , C07D239/46 , C07D239/52 , C07D285/16 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/04 , A61K31/549 , A61K31/513
CPC分类号: C07D239/36 , C07D239/47 , C07D239/52 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/04
摘要: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
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公开(公告)号:US20050065148A1
公开(公告)日:2005-03-24
申请号:US10918318
申请日:2004-08-12
申请人: Jun Feng , Stephen Gwaltney , Stephen Kaldor , Jeffrey Stafford , Michael Wallace , Zhiyuan Zhang
发明人: Jun Feng , Stephen Gwaltney , Stephen Kaldor , Jeffrey Stafford , Michael Wallace , Zhiyuan Zhang
IPC分类号: A61K9/08 , A61K9/20 , A61K31/506 , A61P3/10 , A61P7/00 , A61P13/12 , A61P17/06 , A61P19/00 , A61P19/02 , A61P25/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D239/02 , C07D239/36 , C07D239/46 , C07D239/52 , C07D285/16 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/04 , C07D273/04 , A61K31/539
CPC分类号: C07D239/36 , C07D239/47 , C07D239/52 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/04
摘要: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
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公开(公告)号:US20050004117A1
公开(公告)日:2005-01-06
申请号:US10809635
申请日:2004-03-24
申请人: Jun Feng , Stephen Gwaltney , Stephen Kaldor , Jeffrey Stafford , Michael Wallace , Zhiyuan Zhang
发明人: Jun Feng , Stephen Gwaltney , Stephen Kaldor , Jeffrey Stafford , Michael Wallace , Zhiyuan Zhang
IPC分类号: A61K20060101 , A61K6/00 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/5395 , A61K31/549 , C07D239/95 , C07D285/16 , C07D401/04 , C07D403/04 , C07D417/02 , C07D471/04 , C07D473/18 , C07D487/04
CPC分类号: C07D471/04 , C07D401/04 , C07D403/04 , C07D473/18 , C07D487/04
摘要: Compounds, pharmaceuticals, kits, and methods are provided for use with DPP-IV and other S9 protease that comprise a compound comprising the formula: wherein Q is selected from the group of CO, SO, SO2, or C═NR9; and R1, R2, R3 and R4 are as defined herein.
摘要翻译: 提供化合物,药物,试剂盒和方法用于DPP-IV和其它S9蛋白酶,其包含下式的化合物:其中Q选自CO,SO,SO 2或C = NR 9; 并且R 1,R 2,R 3和R 4如本文所定义。
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公开(公告)号:US20070249611A1
公开(公告)日:2007-10-25
申请号:US11691709
申请日:2007-03-27
申请人: Jun Feng , Stephen Gwaltney , Michael Wallace , Zhiyuan Zhang
发明人: Jun Feng , Stephen Gwaltney , Michael Wallace , Zhiyuan Zhang
IPC分类号: A61K31/498 , A61K31/4745 , A61K31/4704 , C07D487/02
CPC分类号: C07D217/24 , C07D215/227 , C07D215/233 , C07D237/28 , C07D237/32 , C07D239/74 , C07D239/80 , C07D239/88 , C07D239/96 , C07D241/42 , C07D241/44
摘要: Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: wherein the substituents are as defined herein.
摘要翻译: 提供化合物,药物组合物,试剂盒和方法用于DPP-IV和其它S9蛋白酶,其包含下式化合物:其中取代基如本文所定义。
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