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公开(公告)号:US07323570B2
公开(公告)日:2008-01-29
申请号:US11459745
申请日:2006-07-25
申请人: Akiyo K. Claiborne , Stephen L. Gwaltney, II , Lisa A. Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert A. Mantei , Todd W. Rockway , Hing L. Sham , Gerard M. Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
发明人: Akiyo K. Claiborne , Stephen L. Gwaltney, II , Lisa A. Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert A. Mantei , Todd W. Rockway , Hing L. Sham , Gerard M. Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
IPC分类号: C07D401/10 , C07D401/12 , A61K31/44
CPC分类号: C07D233/64 , C07D401/12 , C07D405/12 , C07D409/12
摘要: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
摘要翻译: 具有下式的取代的咪唑和噻唑可用于抑制法呢基转移酶。 还公开了法呢基转移酶抑制组合物和在患者体内抑制法尼基转移酶的方法。
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公开(公告)号:US07211595B2
公开(公告)日:2007-05-01
申请号:US09997323
申请日:2001-11-30
申请人: Akiyo K. Claiborne , Stephen L. Gwaltney, II , Lisa A. Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert A. Mantei , Todd W. Rockway , Hing L. Sham , Gerard M. Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
发明人: Akiyo K. Claiborne , Stephen L. Gwaltney, II , Lisa A. Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert A. Mantei , Todd W. Rockway , Hing L. Sham , Gerard M. Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
IPC分类号: A61K31/415 , C07D401/04 , C07D401/12 , C07D233/32
CPC分类号: C07D233/64 , C07D401/12 , C07D405/12 , C07D409/12
摘要: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
摘要翻译: 具有下式的取代的咪唑和噻唑可用于抑制法呢基转移酶。 还公开了法呢基转移酶抑制组合物和在患者体内抑制法尼基转移酶的方法。
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公开(公告)号:US20060264476A1
公开(公告)日:2006-11-23
申请号:US11459745
申请日:2006-07-25
申请人: Akiyo Claiborne , Stephen Gwaltney , Lisa Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert Mantei , Todd Rockway , Hing Sham , Gerard Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
发明人: Akiyo Claiborne , Stephen Gwaltney , Lisa Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert Mantei , Todd Rockway , Hing Sham , Gerard Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
IPC分类号: A61K31/4439 , C07D403/02
CPC分类号: C07D233/64 , C07D401/12 , C07D405/12 , C07D409/12
摘要: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
摘要翻译: 具有下式的取代的咪唑和噻唑可用于抑制法呢基转移酶。 还公开了法呢基转移酶抑制组合物和在患者体内抑制法尼基转移酶的方法。
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公开(公告)号:US07056925B2
公开(公告)日:2006-06-06
申请号:US10640615
申请日:2003-08-13
申请人: Gaoquan Li , Qun Li , Tongmei Li , Nan-Horng Lin , Robert A. Mantei , Hing L. Sham , Gary T. Wang
发明人: Gaoquan Li , Qun Li , Tongmei Li , Nan-Horng Lin , Robert A. Mantei , Hing L. Sham , Gary T. Wang
IPC分类号: A61K31/4965 , C07D241/00 , C07D241/02 , C07D211/90 , C07D211/78
CPC分类号: C07D239/42 , C07D401/12
摘要: Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译: 具有该式的化合物可用于抑制蛋白激酶。 还公开了制备化合物,含有化合物的组合物和使用该化合物的处理方法的方法。
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公开(公告)号:US06831175B2
公开(公告)日:2004-12-14
申请号:US10317914
申请日:2002-12-12
申请人: Qun Li , Keith W. Woods , Gui-Dong Zhu , John P. Fischer , Jianchun Gong , Tongmei Li , Virajkumar Gandhi , Sheela A. Thomas , Garrick K. Packard , Xiaohong Song , Jason N. Abrams , Robert B. Diebold , Jürgen Dinges , Charles W. Hutchins , Vincent S. Stoll , Saul H. Rosenberg , Vincent L. Giranda
发明人: Qun Li , Keith W. Woods , Gui-Dong Zhu , John P. Fischer , Jianchun Gong , Tongmei Li , Virajkumar Gandhi , Sheela A. Thomas , Garrick K. Packard , Xiaohong Song , Jason N. Abrams , Robert B. Diebold , Jürgen Dinges , Charles W. Hutchins , Vincent S. Stoll , Saul H. Rosenberg , Vincent L. Giranda
IPC分类号: C07D21136
CPC分类号: C07D401/04 , C07D213/63 , C07D401/12 , C07D401/14 , C07D403/14 , C07D409/14 , C07D471/04 , C07D475/02
摘要: Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.
摘要翻译: 具有该化学式的化合物可用于抑制蛋白激酶。 还公开了抑制蛋白激酶的组合物和抑制患者蛋白激酶的方法。
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公开(公告)号:US20110124642A1
公开(公告)日:2011-05-26
申请号:US12949435
申请日:2010-11-18
IPC分类号: A61K31/502 , C07D237/32 , C07D237/30 , C07D471/04 , A61K31/5025 , C07D495/04 , C07D413/12 , A61K31/5377 , C07D237/26 , A61P25/00 , A61P25/22 , A61P25/18 , A61P25/30 , A61P29/00 , A61P13/10
CPC分类号: C07D237/24 , C07D401/12 , C07D405/04 , C07D471/04 , C07D495/04
摘要: Disclosed herein are KCNQ potassium channels modulators of formula (I) wherein ring Z1, R1, p, R3, and R4 are as defined in the specification. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described.
摘要翻译: 本文公开了式(I)的KCNQ钾通道调节剂,其中环Z1,R1,p,R3和R4如说明书中所定义。 包含这些化合物的组合物; 还描述了使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号:US20100234345A1
公开(公告)日:2010-09-16
申请号:US12612504
申请日:2009-11-04
申请人: William A. Carroll , Michael J. Dart , Teodozyj Kolasa , Tongmei Li , Derek W. Nelson , Meena V. Patel , Sridhar Peddi , Arturo Perez-Medrano , Xueqing Wang
发明人: William A. Carroll , Michael J. Dart , Teodozyj Kolasa , Tongmei Li , Derek W. Nelson , Meena V. Patel , Sridhar Peddi , Arturo Perez-Medrano , Xueqing Wang
IPC分类号: A61K31/397 , C07D275/03 , A61K31/425 , C07D275/04 , A61K31/428 , C07D413/02 , A61K31/5377 , C07D277/02 , A61K31/426 , C07D417/14 , A61K31/4439 , C07D513/02 , A61K31/437 , C07D215/00 , A61K31/4709 , C07D417/02 , A61K31/454 , A61K31/497 , A61P29/00 , A61P25/00 , A61P35/00 , A61P37/00 , A61P11/00 , A61P9/00
CPC分类号: C07D275/02 , C07D275/04 , C07D417/04 , C07D417/06 , C07D417/12 , C07D513/04 , C07D513/10 , Y02P20/582
摘要: The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R1, R2, R3, R4, and L are as defined in the specification, compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions.
摘要翻译: 本申请涉及含有异噻唑基的式(I)化合物,其中R 1,R 2,R 3,R 4和L如说明书中所定义,包含这些化合物的组合物,以及使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号:US20100093814A1
公开(公告)日:2010-04-15
申请号:US12274105
申请日:2008-11-19
申请人: Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
发明人: Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
IPC分类号: A61K31/426 , C07D277/28 , A61P25/00
CPC分类号: C07D277/46 , C07D277/28 , C07D277/48 , C07D277/60 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04 , C07D513/08
摘要: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a, Rx, and n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译: 本发明涉及式(I)化合物或其药物盐,前体药物,前体药物或其组合的盐,其中R1,R2,R3,R4和L1在具体实施方案中定义,包含这些化合物的组合物和方法 使用这些化合物和组合物治疗病症和病症。 本发明还涉及式(II)化合物或其药物盐,前药,前体药物或其组合的盐,其中R 1a,R 2a,R x和n如说明书中所定义,包含这些化合物的组合物和方法 使用这些化合物和组合物治疗病症和病症。
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公开(公告)号:US20090105306A1
公开(公告)日:2009-04-23
申请号:US12246808
申请日:2008-10-07
申请人: William A. Carroll , Michael J. Dart , Arturo Perez-Medrano , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Jennifer Frost , Teodozyj Kolasa , Bo Liu , Steven P. Latshaw , Xueqing Wang
发明人: William A. Carroll , Michael J. Dart , Arturo Perez-Medrano , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Jennifer Frost , Teodozyj Kolasa , Bo Liu , Steven P. Latshaw , Xueqing Wang
IPC分类号: A61K31/433 , C07D417/02 , C07D285/12 , C07D405/02 , C07D413/02 , A61P29/00 , A61P9/00 , A61P35/00 , A61P37/00 , A61P25/00 , A61K31/443 , A61K31/422 , A61K31/4155
CPC分类号: C07D405/06 , C07D405/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14
摘要: The present invention relates compounds of formula (I) wherein A and R1 are as defined in the specification, pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions.
摘要翻译: 本发明涉及式(I)的化合物,其中A和R 1如说明书中所定义,包含这些化合物的药物组合物,以及使用这些化合物和药物组合物治疗病症和障碍的方法。
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公开(公告)号:US20090023789A1
公开(公告)日:2009-01-22
申请号:US12100731
申请日:2008-04-10
申请人: William A. Carroll , Michael J. Dart , Teodozyj Kolasa , Tongmei Li , Derek W. Nelson , Meena V. Patel , Sridhar Peddi , Arturo Perez-Medrano , Xueqing Wang
发明人: William A. Carroll , Michael J. Dart , Teodozyj Kolasa , Tongmei Li , Derek W. Nelson , Meena V. Patel , Sridhar Peddi , Arturo Perez-Medrano , Xueqing Wang
IPC分类号: A61K31/425 , C07D275/02 , A61P29/00 , A61P35/00 , A61P9/00 , A61P25/00
CPC分类号: A61K31/425 , A61K31/427 , A61K31/429 , A61K31/4436 , A61K31/4725 , A61K31/5377 , C07D275/02 , C07D275/04 , C07D417/04 , C07D417/06 , C07D417/12 , C07D513/04 , C07D513/10 , Y02P20/582
摘要: The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R1, R2, R3, R4, and L are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译: 本申请涉及含有异噻唑基的式(I)化合物,其中R 1,R 2,R 3,R 4和L如说明书中所定义,包含这些化合物的组合物,以及使用这些化合物和组合物治疗病症和障碍的方法。
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