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    COMPOSITIONS AND METHODS FOR REDUCING TRIGLYCERIDE LEVELS
    1.
    发明申请
    COMPOSITIONS AND METHODS FOR REDUCING TRIGLYCERIDE LEVELS 审中-公开
    用于降低TRIGLYCERIDE水平的组合物和方法

    公开(公告)号：US20100130608A1

    公开(公告)日：2010-05-27

    申请号：US12572263

    申请日：2009-10-01

    申请人： Alan Stuart RYAN ,  Edward B. Nelson ,  Jung Lee ,  Krishna Raman

    发明人： Alan Stuart RYAN ,  Edward B. Nelson ,  Jung Lee ,  Krishna Raman

    IPC分类号： A61K31/22 ,  A61K31/202 ,  A61P3/00

    CPC分类号： A61K31/232 ,  A61K31/20 ,  A61K31/201 ,  A61K2300/00

    摘要： The present invention is directed to methods of reducing plasma triglyceride level in subjects by administering docosahexaenoic acid (DHA). The method can comprise administering daily to the subject a dosage form comprising docosahexaenoic acid ester substantially free of eicosapentaenoic acid (EPA), wherein the DHA is derived from an algal source. In some embodiments, the method comprises administering daily to the subject a dosage form comprising DHA ester substantially free of EPA, wherein the DHA ester is about 60% to about 99.5% (w/w) of the total fatty acid content of the dosage form. In some embodiments, the method comprises administering daily to the subject a dosage form comprising about 200 mg to about 4 g of DHA ester substantially free of EPA. In some embodiments, the foregoing methods also result in a lowering of the amount of total cholesterol in the subject.

    摘要翻译： 本发明涉及通过施用二十二碳六烯酸（DHA）来减少受试者血浆甘油三酯水平的方法。 该方法可以包括向受试者施用基本上不含二十碳五烯酸（EPA）的二十二碳六烯酸酯的剂型，其中DHA来源于藻源。 在一些实施方案中，该方法包括向受试者施用包含基本上不含EPA的DHA酯的剂型，其中DHA酯为剂型总脂肪酸含量的约60％至约99.5％（w / w） 。 在一些实施方案中，该方法包括向受试者施用包含约200mg至约4g基本上不含EPA的DHA酯的剂型。 在一些实施方案中，前述方法还导致受试者中总胆固醇的量的降低。

    Process for the preparation of aryl-substituted propionic acid esters
    6.
    发明授权
    Process for the preparation of aryl-substituted propionic acid esters 失效
    芳基取代的丙酸酯的制备方法

    公开(公告)号：US5264612A

    公开(公告)日：1993-11-23

    申请号：US952118

    申请日：1992-09-28

    申请人： Eric J. Evain ,  Krishna Raman

    发明人： Eric J. Evain ,  Krishna Raman

    IPC分类号： B01J23/02 ,  B01J31/02 ,  B01J31/12 ,  C07B61/00 ,  C07C67/347 ,  C07C69/732 ,  C07C69/76

    CPC分类号： C07C67/347

    摘要： Disclosed is a process for the preparation of aryl-substituted propionic acid esters having the formula: ##STR1## wherein R and R.sup.1 are a C.sub.1 -C.sub.12 linear or branched alkyl, a C.sub.5 -C.sub.12 cycloalkyl, a C.sub.6 -C.sub.12 aryl or a C.sub.7 -C.sub.12 alkaryl or aralkyl, R.sup.2 is hydrogen or a C.sub.1 -C.sub.20 linear or branched alkyl and R.sup.3 is a C.sub.1 -C.sub.20 linear or branched alkyl, a C.sub.5 -C.sub.12 cycloalkyl, a C.sub.6 -C.sub.12 aryl or a C.sub.7 -C.sub.20 alkaryl or aralkyl, and may be the same or different, or R.sup.1 is hydrogen, which comprises forming a reaction mixture of a phenol, at least one base catalyst and an acrylate, in the presence of 1,2-dimethoxybenzene, wherein the acrylate is added at once or over a period of time from 5 to 60 minutes at atmospheric pressure. The process results in excellent yields of the desired product with good rates of conversion.

    MICROBIAL OILS ENRICHED IN POLYUNSATURATED FATTY ACIDS
    7.
    发明申请
    MICROBIAL OILS ENRICHED IN POLYUNSATURATED FATTY ACIDS 审中-公开
    微生物油在多糖脂肪酸中增加

    公开(公告)号：US20140323569A1

    公开(公告)日：2014-10-30

    申请号：US14234104

    申请日：2012-07-20

    申请人： Krishna Raman

    发明人： Krishna Raman

    IPC分类号： A61K31/232 ,  A61K31/202

    CPC分类号： A61K31/232 ,  A21D2/165 ,  A23D9/00 ,  A23K20/158 ,  A23L5/00 ,  A23L7/104 ,  A23L9/00 ,  A23L31/00 ,  A23L33/115 ,  A23V2002/00 ,  A61K31/202 ,  C11B1/00 ,  C11B1/10 ,  C11B3/04 ,  C11B3/06 ,  C11C3/003 ,  C11C3/10 ,  C12P7/6472 ,  C12R1/89 ,  A23V2200/326 ,  A23V2250/187 ,  A23V2250/1882

    摘要： The present invention is directed to microbial oils that are enriched in their content of polyunsaturated fatty acids, their esters, their acid salts, alcohols formed therefrom, and/or aldehydes formed therefrom. The present invention is further directed to compositions containing the enriched microbial oils and methods of making and using the enriched microbial oils. The present invention is also directed to isolated microorganisms as well as strains and mutants thereof, biomasses, microbial oils, compositions, and cultures; methods of producing the microbial oils, biomasses, and mutants; and methods of using the isolated microorganisms, biomasses, and microbial oils.

    摘要翻译： 本发明涉及富含多不饱和脂肪酸含量的微生物油，它们的酯，它们的酸盐，由其形成的醇和/或由其形成的醛。 本发明还涉及含有富集的微生物油的组合物和制备和使用富集的微生物油的方法。 本发明还涉及分离的微生物以及其菌株和突变体，生物质，微生物油，组合物和培养物; 生产微生物油，生物质和突变体的方法; 以及使用分离的微生物，生物质和微生物油的方法。

    AUTOMATED DEPLOYMENT OF AN APPLICATION IN A COMPUTING PLATFORM
    9.
    发明申请
    AUTOMATED DEPLOYMENT OF AN APPLICATION IN A COMPUTING PLATFORM 有权
    自动部署在计算机平台中的应用

    公开(公告)号：US20130198719A1

    公开(公告)日：2013-08-01

    申请号：US13363173

    申请日：2012-01-31

    申请人： Krishna Raman

    发明人： Krishna Raman

    IPC分类号： G06F9/445 ,  G06F9/45 ,  G06F9/44

    CPC分类号： G06F8/61 ,  G06F8/65 ,  G06F9/44505

    摘要： A platform executing on a computer system configures an application and components that provide capabilities to the application based on an application descriptor of the application, the application and the components to be run on a plurality of nodes of the platform that are arranged in a cluster. The platform assigns a first set of the components to run on a first node of the plurality of nodes and a second set of on the components to run on a second node of the plurality of nodes. The platform installs the first set of the components on the first node and the second set of the components on the second node.

    摘要翻译： 在计算机系统上执行的平台基于应用程序的应用程序描述符，应用程序和要在群集中排列的平台的多个节点上运行的组件来配置向应用程序提供功能的应用程序和组件。 平台分配第一组要在多个节点的第一节点上运行的组件，以及组件上的第二组，以在多个节点的第二节点上运行。 平台在第一个节点上安装第一组组件，在第二个节点上安装第二组组件。