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公开(公告)号:US08580829B2
公开(公告)日:2013-11-12
申请号:US13215654
申请日:2011-08-23
申请人: Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin Liu , Ho Yin Lo , Pui Leng Loke , Tina Marie Morwick , Peter Allen Nemoto , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
发明人: Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin Liu , Ho Yin Lo , Pui Leng Loke , Tina Marie Morwick , Peter Allen Nemoto , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
CPC分类号: C07D413/14 , A61K31/4245 , C07D413/10 , C07D417/14
摘要: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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公开(公告)号:US08658661B2
公开(公告)日:2014-02-25
申请号:US13208582
申请日:2011-08-12
申请人: Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , John D. Huber , Ho Yin Lo , Pui Leng Loke , Weimin Liu , Tina Marie Morwick , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
发明人: Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , John D. Huber , Ho Yin Lo , Pui Leng Loke , Weimin Liu , Tina Marie Morwick , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
IPC分类号: A01N43/54 , A61K31/505
CPC分类号: C07D413/14 , C07D413/10 , C07D417/14 , C07D471/04 , C07D498/04
摘要: The present invention relates to compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,其中R 1 -R 5如本文所定义。 本发明还涉及包含这些化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号:US08575201B2
公开(公告)日:2013-11-05
申请号:US13237112
申请日:2011-09-20
申请人: Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin W. Liu , Pui Leng Loke , Tina Marie Morwick , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
发明人: Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin W. Liu , Pui Leng Loke , Tina Marie Morwick , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
CPC分类号: C07D413/14
摘要: The present invention relates to compounds of formula (I) and (IA): and pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译: 本发明涉及式(I)和(IA)化合物及其药学上可接受的盐,其中R 1 -R 5如本文所定义。 本发明还涉及包含这些化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号:US08420655B2
公开(公告)日:2013-04-16
申请号:US12957766
申请日:2010-12-01
申请人: Zhidong Chen , Ming-Hong Hao , Weimin Liu , Ho-Yin Lo , Pui Leng Loke , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Hidenori Takahashi , Heather Tye , Lifen Wu
发明人: Zhidong Chen , Ming-Hong Hao , Weimin Liu , Ho-Yin Lo , Pui Leng Loke , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Hidenori Takahashi , Heather Tye , Lifen Wu
IPC分类号: A61K31/506 , C07D403/14
CPC分类号: C07D471/04 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salt thereof, wherein R1-R7 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐,其中R 1 -R 7如本文所定义。 本发明还涉及包含这些化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号:US09073895B2
公开(公告)日:2015-07-07
申请号:US13325564
申请日:2011-12-14
申请人: Angela Berry , Zhidong Chen , Stephane De Lombaert , Michel Jose Emmanuel , Pui Leng Loke , Chuk Chui Man , Tina Marie Morwick , Hidenori Takahashi
发明人: Angela Berry , Zhidong Chen , Stephane De Lombaert , Michel Jose Emmanuel , Pui Leng Loke , Chuk Chui Man , Tina Marie Morwick , Hidenori Takahashi
IPC分类号: C07D213/72 , A61K31/345 , C07D405/10 , C07D239/42 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号: C07D405/10 , C07D239/42 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, C, R1a, R1b, R2, R3, R4a and R4b are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐,其中A,B,C,R 1a,R 1b,R 2,R 3,R 4a和R 4b如本文所定义。 本发明还涉及包含这些化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号:US09150556B2
公开(公告)日:2015-10-06
申请号:US12596152
申请日:2008-05-15
申请人: Asitha Abeywardane , Brian Nicholas Cook , Stephane De Lombaert , Michel Jose Emmanuel , Xin Guo , Ming-Hong Hao , Jin Mi Kim , Ho Yin Lo , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Kevin Chungeng Qian , Hidenori Takahashi , Steven John Taylor
发明人: Asitha Abeywardane , Brian Nicholas Cook , Stephane De Lombaert , Michel Jose Emmanuel , Xin Guo , Ming-Hong Hao , Jin Mi Kim , Ho Yin Lo , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Kevin Chungeng Qian , Hidenori Takahashi , Steven John Taylor
IPC分类号: C07D235/26 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04
CPC分类号: C07D409/06 , C07D235/26 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04
摘要: Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase.
摘要翻译: 公开了可用于治疗涉及胃促胰酶的各种疾病和病症的小分子抑制剂。
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公开(公告)号:US20100240702A1
公开(公告)日:2010-09-23
申请号:US12596152
申请日:2008-05-15
申请人: Asitha Abeywardane , Brian Nicholas Cook , Stephane De Lombaert , Michel Jose Emmanuel , Xin Guo , Ming-Hong Hao , Jin Mi Kim , Ho Yin Lo , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Kevin Chungeng Qian , Hidenori Takahashi , Steven John Taylor
发明人: Asitha Abeywardane , Brian Nicholas Cook , Stephane De Lombaert , Michel Jose Emmanuel , Xin Guo , Ming-Hong Hao , Jin Mi Kim , Ho Yin Lo , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Kevin Chungeng Qian , Hidenori Takahashi , Steven John Taylor
IPC分类号: A61K31/454 , C07D235/26 , C07D211/32 , A61K31/4166 , A61P9/12 , A61P9/10 , A61P13/12
CPC分类号: C07D409/06 , C07D235/26 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04
摘要: Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase.
摘要翻译: 公开了可用于治疗涉及胃促胰酶的各种疾病和病症的小分子抑制剂。
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公开(公告)号:US07329764B2
公开(公告)日:2008-02-12
申请号:US10902562
申请日:2004-07-29
申请人: Zhidong Chen , John David Ginn , Eugene Richard Hickey , Weimin Liu , Can Mao , Tina Marie Morwick , Peter Allen Nemoto , Denice Spero , Sanxing Sun
发明人: Zhidong Chen , John David Ginn , Eugene Richard Hickey , Weimin Liu , Can Mao , Tina Marie Morwick , Peter Allen Nemoto , Denice Spero , Sanxing Sun
IPC分类号: C07D333/00 , A61K31/38
CPC分类号: C07D409/04 , A61K31/38 , C07D333/70 , C07D409/14
摘要: Disclosed are compounds of the formula I shown below, wherein R1, R2, R3 and R4 are described herein, which are active as anti-inflammatory agents. Also disclosed are methods of using and making such compounds
摘要翻译: 公开了下文所示的式I化合物,其中R1,R2,R3和R4如本文所述,其作为抗炎剂是有活性的。 还公开了使用和制备这些化合物的方法
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公开(公告)号:US07291733B2
公开(公告)日:2007-11-06
申请号:US10960550
申请日:2004-10-07
申请人: Charles Lawrence Cywin , Roman Wolfgang Fleck , Eugene Richard Hickey , Weimin Liu , Tina Marie Morwick , John Robert Proudfoot , Denice M. Spero
发明人: Charles Lawrence Cywin , Roman Wolfgang Fleck , Eugene Richard Hickey , Weimin Liu , Tina Marie Morwick , John Robert Proudfoot , Denice M. Spero
IPC分类号: C07D491/00 , C07D498/00 , C07D513/00 , C07D515/00
CPC分类号: C07D495/14
摘要: Disclosed are substituted tricyclic heterocycle compounds of the formulas (I), (II) and (III) shown below, wherein R1, R2, R3 and R4 are described herein, which are active as anti-inflammatory agents. Also disclosed are methods of using and making such compounds
摘要翻译: 公开了以下所示的式(I),(II)和(III)的取代的三环杂环化合物,其中R 1,R 2,R 3, 本文描述了它们作为抗炎剂是有活性的。 还公开了使用和制备这些化合物的方法
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10.
公开(公告)号:US07265132B2
公开(公告)日:2007-09-04
申请号:US10937533
申请日:2004-09-09
申请人: Michel Jose Emmanuel , Leah L. Frye , Eugene R. Hickey , Weimin Liu , Tina Marie Morwick , Denice Mary Spero , David S. Thomson , Yancey David Ward , Erick Richard Roush Young
发明人: Michel Jose Emmanuel , Leah L. Frye , Eugene R. Hickey , Weimin Liu , Tina Marie Morwick , Denice Mary Spero , David S. Thomson , Yancey David Ward , Erick Richard Roush Young
IPC分类号: A61K31/445 , C07D211/06 , C07D211/56
CPC分类号: C07D401/12 , C04B35/632 , C07D205/04 , C07D207/14 , C07D207/16 , C07D211/58 , C07D211/60 , C07D211/66 , C07D309/14 , C07D335/02 , C07D401/04 , C07D403/06 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D455/02 , C07D487/08
摘要: Disclosed are cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds
摘要翻译: 公开了本文进一步定义的组合蛋白酶S,K,F,L和B可逆抑制化合物(I),(II),(Ia)和(Ib)。 该化合物可用于治疗自身免疫性疾病。 还公开了制备这些新化合物的方法
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