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公开(公告)号:US09174980B2
公开(公告)日:2015-11-03
申请号:US13752640
申请日:2013-01-29
申请人: Alessandra Bartolozzi , Zhidong Chen , Jonathon Alan Dines , Ho Yin Lo , Pui Leng Loke , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
发明人: Alessandra Bartolozzi , Zhidong Chen , Jonathon Alan Dines , Ho Yin Lo , Pui Leng Loke , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
IPC分类号: C07D403/10 , A61K31/404 , C07D471/04 , C07D409/14 , C07D413/14 , C07D403/14 , C07D417/14 , C07D413/10 , C07D417/10 , C07D405/14 , C07D401/14 , C07D401/12
CPC分类号: C07D471/04 , A61K31/404 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14
摘要: The present invention relates to compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R1-R7, A and HET are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,其中R 1 -R 7,A和HET如本文所定义。 本发明还涉及包含这些化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号:US08580829B2
公开(公告)日:2013-11-12
申请号:US13215654
申请日:2011-08-23
申请人: Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin Liu , Ho Yin Lo , Pui Leng Loke , Tina Marie Morwick , Peter Allen Nemoto , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
发明人: Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin Liu , Ho Yin Lo , Pui Leng Loke , Tina Marie Morwick , Peter Allen Nemoto , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
CPC分类号: C07D413/14 , A61K31/4245 , C07D413/10 , C07D417/14
摘要: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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公开(公告)号:US08658661B2
公开(公告)日:2014-02-25
申请号:US13208582
申请日:2011-08-12
申请人: Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , John D. Huber , Ho Yin Lo , Pui Leng Loke , Weimin Liu , Tina Marie Morwick , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
发明人: Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , John D. Huber , Ho Yin Lo , Pui Leng Loke , Weimin Liu , Tina Marie Morwick , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
IPC分类号: A01N43/54 , A61K31/505
CPC分类号: C07D413/14 , C07D413/10 , C07D417/14 , C07D471/04 , C07D498/04
摘要: The present invention relates to compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,其中R 1 -R 5如本文所定义。 本发明还涉及包含这些化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号:US08580825B2
公开(公告)日:2013-11-12
申请号:US13237106
申请日:2011-09-20
申请人: Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , John D. Huber , Weimin Liu , Ho Yin Lo , Pui Leng Loke , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
发明人: Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , John D. Huber , Weimin Liu , Ho Yin Lo , Pui Leng Loke , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
CPC分类号: C07D413/14
摘要: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐,其中R 1 -R 5如本文所定义。 本发明还涉及包含这些化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号:US08829200B2
公开(公告)日:2014-09-09
申请号:US13281685
申请日:2011-10-26
申请人: Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , Weimin Liu , Ho Yin Lo , Pui Leng Loke
发明人: Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , Weimin Liu , Ho Yin Lo , Pui Leng Loke
IPC分类号: A61K31/506 , A61K31/4184 , A61K31/5377 , C07D403/04 , C07D403/14 , C07D413/14 , C07D405/14
CPC分类号: C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14
摘要: The present invention relates to compounds of formula (IA) and (IB): and pharmaceutically acceptable salts thereof, wherein R1-R7 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译: 本发明涉及式(IA)和(IB)的化合物及其药学上可接受的盐,其中R 1 -R 7如本文所定义。 本发明还涉及包含这些化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号:US08618300B2
公开(公告)日:2013-12-31
申请号:US13061996
申请日:2009-08-25
IPC分类号: C07D221/02
CPC分类号: C07D471/04
摘要: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salt thereof, wherein X1 to X4, R1 to R4, A, B, D and m are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐,其中X 1至X 4,R 1至R 4,A,B,D和m如本文所定义。 本发明还涉及包含这些化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号:US20110275627A1
公开(公告)日:2011-11-10
申请号:US13061996
申请日:2009-08-25
IPC分类号: A61K31/5377 , A61K31/437 , C07D403/14 , A61K31/506 , C07D215/14 , A61P13/12 , C07D413/14 , A61P29/00 , A61P11/00 , A61P37/08 , A61P9/00 , A61P35/00 , C07D471/04 , A61K31/4709
CPC分类号: C07D471/04
摘要: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salt thereof, wherein X1 to X4, R1 to R4, A, B, D and m are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐,其中X 1至X 4,R 1至R 4,A,B,D和m如本文所定义。 本发明还涉及包含这些化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号:US09062056B2
公开(公告)日:2015-06-23
申请号:US13062749
申请日:2009-08-25
申请人: Michel Jose Emmanuel , Xin Guo , Jin Mi Kim , Ho Yin Lo , Peter Allen Nemoto , Kevin Chungeng Qian
发明人: Michel Jose Emmanuel , Xin Guo , Jin Mi Kim , Ho Yin Lo , Peter Allen Nemoto , Kevin Chungeng Qian
IPC分类号: C07D471/04 , C07D487/04
CPC分类号: C07D487/04 , C07D471/04
摘要: Disclosed are small molecule inhibitors of the formula (I): and the pharmaceutical compositions thereof and processes of making the same. The compounds are useful in treating various diseases and conditions involving chymase.
摘要翻译: 公开了式(I)的小分子抑制剂及其药物组合物及其制备方法。 该化合物可用于治疗涉及胃促胰酶的各种疾病和病症。
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公开(公告)号:US08377949B2
公开(公告)日:2013-02-19
申请号:US12673103
申请日:2008-08-12
申请人: Xin Guo , Ho Yin Lo , Chuk Chui Man , Hidenori Takahashi
发明人: Xin Guo , Ho Yin Lo , Chuk Chui Man , Hidenori Takahashi
IPC分类号: A01N43/54 , A61K31/517 , C07D491/00
CPC分类号: C07D403/06 , C07D417/06
摘要: Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving Chymase.
摘要翻译: 公开了可用于治疗涉及糜酶的各种疾病和病症的小分子抑制剂。
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公开(公告)号:US20110269780A1
公开(公告)日:2011-11-03
申请号:US13062749
申请日:2009-08-25
申请人: Michel Jose Emmanuel , Xin Guo , Jin Mi Kim , Ho Yin Lo , Peter Allen Nemoto , Kevin Chungeng Qian
发明人: Michel Jose Emmanuel , Xin Guo , Jin Mi Kim , Ho Yin Lo , Peter Allen Nemoto , Kevin Chungeng Qian
IPC分类号: A61K31/522 , C07D473/00 , A61K31/437 , A61P9/04 , A61P13/12 , A61P11/00 , A61P9/12 , A61P29/00 , A61P9/10 , A61P9/00 , C07D471/04 , A61P11/06
CPC分类号: C07D487/04 , C07D471/04
摘要: Disclosed are small molecule inhibitors of the formula (I): and the pharmaceutical compositions thereof and processes of making the same. The compounds are useful in treating various diseases and conditions involving chymase.
摘要翻译: 公开了式(I)的小分子抑制剂及其药物组合物及其制备方法。 该化合物可用于治疗涉及胃促胰酶的各种疾病和病症。
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