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1.Heterocyclylmethyl-substituted pyrazole derivatives and their use for treating cardiovascular diseases 失效
标题翻译: 杂环甲基取代的吡唑衍生物及其用于治疗心血管疾病的用途公开(公告)号:US6166027A
公开(公告)日:2000-12-26
申请号:US284172
申请日:1999-04-09
申请人: Alexander Straub , Chantal Furstner , Ulrich Niewohner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hutter , Klaus Dembowsky , Dieter Arlt
发明人: Alexander Straub , Chantal Furstner , Ulrich Niewohner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hutter , Klaus Dembowsky , Dieter Arlt
IPC分类号: A61K31/416 , A61K31/422 , A61K31/427 , A61K31/443 , A61K31/4433 , A61K31/501 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P25/28 , C07D20060101 , C07D263/32 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04 , A61K31/506
CPC分类号: C07D401/04 , C07D263/32 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要: The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
摘要翻译: PCT No.PCT / EP97 / 05432 Sec。 371日期1999年4月9日第 102(e)日期1999年4月9日PCT 1997年10月2日PCT公布。 第WO98 / 16507号公报 日期:1998年4月23日本发明涉及新的杂环基甲基取代的吡唑衍生物,其制备方法及其作为药物的用途,特别是用于治疗心血管疾病的药物。
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公开(公告)号:US06414009B1
公开(公告)日:2002-07-02
申请号:US09648082
申请日:2000-08-25
申请人: Alexander Straub , Chantal Fürstner , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky , Dieter Arlt
发明人: Alexander Straub , Chantal Fürstner , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky , Dieter Arlt
IPC分类号: A61K31416
CPC分类号: C07D401/04 , C07D263/32 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要: The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
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公开(公告)号:US06462068B1
公开(公告)日:2002-10-08
申请号:US09644305
申请日:2000-08-23
申请人: Alexander Straub , Chantal Fürstner , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky , Dieter Arlt
发明人: Alexander Straub , Chantal Fürstner , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky , Dieter Arlt
IPC分类号: A61K31416
CPC分类号: C07D401/04 , C07D263/32 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要: The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
摘要翻译: 本发明涉及新的杂环基甲基取代的吡唑衍生物,其制备方法及其作为药物的用途,特别是用于治疗心血管疾病的药物。
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公开(公告)号:US06410740B1
公开(公告)日:2002-06-25
申请号:US09645834
申请日:2000-08-25
申请人: Alexander Straub , Chantal Fürstner , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky , Dieter Arlt
发明人: Alexander Straub , Chantal Fürstner , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky , Dieter Arlt
IPC分类号: C07D41304
CPC分类号: C07D401/04 , C07D263/32 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要: The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
摘要翻译: 本发明涉及新的杂环基甲基取代的吡唑衍生物,其制备方法及其作为药物的用途,特别是用于治疗心血管疾病的药物。
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公开(公告)号:US06387940B1
公开(公告)日:2002-05-14
申请号:US09644179
申请日:2000-08-23
申请人: Alexander Straub , Chantal Fürstner , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky , Dieter Arlt
发明人: Alexander Straub , Chantal Fürstner , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky , Dieter Arlt
IPC分类号: A61K314155
CPC分类号: C07D401/04 , C07D263/32 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要: The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
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6.Use of condensated (hetaryl-substituted) 1-benzal-3-pyrazol derivates for treating special diseases of the cardiovascular and the central nervous systems 失效
标题翻译: 使用缩合(杂芳基取代的)1-苄基-3-吡唑衍生物治疗心血管和中枢神经系统的特殊疾病公开(公告)号:US06180656B2
公开(公告)日:2001-01-30
申请号:US09284032
申请日:1999-04-06
申请人: Chantal F{umlaut over (u)}rstner , Alexander Straub , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim H{umlaut over (u)}tter , Klaus Dembowsky
发明人: Chantal F{umlaut over (u)}rstner , Alexander Straub , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim H{umlaut over (u)}tter , Klaus Dembowsky
IPC分类号: A61K31415
CPC分类号: C07D405/04 , A61K31/416
摘要: The present invention relates to the new use of 1-benzyl-3-(substituted hetaryl)-fused pyrazole derivatives, some of which are known, of the general formula (I) in which R1 to R4 have the meaning indicated in the description, as medicaments, and to new active compounds, in particular to their use as vasodilators, if appropriate in combination with organic nitrates and NO donors and if appropriate in combination with compounds which inhibit the degradation of cGMP.
摘要翻译: 本发明涉及1-苄基-3-(取代的杂芳基) - 引入的吡唑衍生物的新用途,其中一些是已知的通式(I),其中R 1至R 4具有说明书中指出的含义, 作为药物,以及新的活性化合物,特别是它们用作血管舒张剂,如果适合与有机硝酸盐和NO供体结合使用,并且适当时与抑制cGMP降解的化合物组合使用。
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7.Substituted pyrazole derivatives for the treatment of cardiocirculatory diseases 失效
标题翻译: 用于治疗心脏循环疾病的取代的吡唑衍生物公开(公告)号:US06451805B1
公开(公告)日:2002-09-17
申请号:US09297121
申请日:1999-04-23
申请人: Alexander Straub , Chantal Fürstner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky
发明人: Alexander Straub , Chantal Fürstner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky
IPC分类号: A61K31506
CPC分类号: C07D405/04 , C07D471/04 , C07D487/04
摘要: The present invention relates to new substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for the treatment of cardiovascular disorders.
摘要翻译: 本发明涉及新的取代的吡唑衍生物,其制备方法及其作为药物的用途,特别是用于治疗心血管疾病的药物。
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公开(公告)号:US20140088041A1
公开(公告)日:2014-03-27
申请号:US13880985
申请日:2011-09-30
申请人: Bernd Koop , Martin Kugler , Thomas Jaetsch , Johannes Kaulen , Tanja Gerharz
发明人: Bernd Koop , Martin Kugler , Thomas Jaetsch , Johannes Kaulen , Tanja Gerharz
CPC分类号: A01N43/56 , A01N31/08 , A01N33/04 , A01N33/12 , A01N43/80 , A01N47/12 , A01N55/08 , A01N59/14 , B27K3/343 , B27K3/40 , B27K2240/20 , A01N2300/00 , A01N31/16
摘要: The invention relates to mixtures comprising penflufen, to the use of these mixtures for protecting industrial materials and to a method for treating industrial materials with the penflufen mixtures.
摘要翻译: 本发明涉及使用这些混合物来保护工业材料的笔弗卢芬的混合物以及用氟氟烷混合物处理工业材料的方法。
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公开(公告)号:US20110098279A1
公开(公告)日:2011-04-28
申请号:US12982927
申请日:2010-12-31
申请人: Rainer Bruns , Martin Kugler , Thomas Jaetsch , Hans-Ludwig Elbe , Dietmar Kuhnt , Olaf Gebauer , Heiko Rieck
发明人: Rainer Bruns , Martin Kugler , Thomas Jaetsch , Hans-Ludwig Elbe , Dietmar Kuhnt , Olaf Gebauer , Heiko Rieck
CPC分类号: C07D487/04 , A01N43/90
摘要: Use of compounds of the formula (I) in which R1, R2, R3 and R4 are as defined in the description for protecting engineered materials.
摘要翻译: 使用式(I)化合物,其中R 1,R 2,R 3和R 4如在保护工程材料的描述中所定义。
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公开(公告)号:US07176228B2
公开(公告)日:2007-02-13
申请号:US10333598
申请日:2001-07-11
申请人: Hans-Ludwig Elbe , Heiko Rieck , Ralf Dunkel , Ulrike Wachendorff-Neumann , Astrid Mauler-Machnik , Karl-Heinz Kuck , Martin Kugler , Thomas Jaetsch
发明人: Hans-Ludwig Elbe , Heiko Rieck , Ralf Dunkel , Ulrike Wachendorff-Neumann , Astrid Mauler-Machnik , Karl-Heinz Kuck , Martin Kugler , Thomas Jaetsch
IPC分类号: A61K31/415 , C07D231/10 , C07D231/12 , C07D231/16
CPC分类号: C07D213/82 , A01N43/10 , A01N43/40 , A01N43/56 , A01N43/74 , C07C251/48 , C07D207/34 , C07D231/14 , C07D263/34 , C07D277/56 , C07D279/12 , C07D307/30 , C07D307/54 , C07D307/71 , C07D333/38
摘要: The invention relates to biphenylcarboxamides of the formula (I) in which A, R, Z, X, Y, m and n are each as defined in the disclosure, to a plurality of processes for preparing these substances, to their use for controlling undesirable microorganisms, and to novel intermediates and their preparation.
摘要翻译: 本发明涉及式(I)的联苯甲酰胺,其中A,R,Z,X,Y,m和n各自如本公开所定义,涉及制备这些物质的多种方法,用于控制不期望的 微生物和新型中间体及其制备。
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