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公开(公告)号：US20090143437A1
公开(公告)日：2009-06-04
申请号：US12360954
申请日：2009-01-28
申请人： Alexander W. Oxford , Richard J. Davis , Robert A. Coleman , Kenneth L. Clark , David E. Clark , Neil V. Harris , Garry Fenton , George Hynd , Keith A.J. Stuttle , Jonathan M. Sutton , Christopher G. Newton
发明人： Alexander W. Oxford , Richard J. Davis , Robert A. Coleman , Kenneth L. Clark , David E. Clark , Neil V. Harris , Garry Fenton , George Hynd , Keith A.J. Stuttle , Jonathan M. Sutton , Christopher G. Newton
IPC分类号： A61K31/341 , A61K31/422 , A61K31/443 , A61P25/00
CPC分类号： C07D307/54 , A61K31/34 , A61K31/341 , A61K31/4155 , A61K31/443 , C07D307/64 , C07D307/68 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Compounds of formula (X): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O)2, or NRN1, where RN1 is selected from H or optionally substituted C1-4 alkyl, or Y is —C(═O)NRN2—, where RN2 is selected from H, and optionally substituted C1-7 alkyl or C5-20 aryl; R3 is an optionally substituted C6 aryl group linked to a further optionally substituted C6 aryl group, wherein if both C6 aryl groups are benzene rings, there may be an oxygen bridge between the two rings, bound adjacent the link on both rings; A is a single bond or a C1-3 alkylene group; and R5 is either: (i) carboxy; (ii) a group of formula (II): or (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted alkyl; (iv) tetrazol-5-yl.
摘要翻译： 式（X）的化合物：其中：R 2为H或任选取代的C 1-4烷基; Y是 - （CH 2）n X-，其中n是1或2，X是O，S，S（-O），S（-O）2或NRN1，其中RN1选自H或任选取代的C1- 4烷基或Y是-C（-O）NRN 2 - ，其中RN 2选自H，和任选取代的C 1-7烷基或C 5-20芳基; R3是与另外任意取代的C 6芳基连接的任意取代的C6芳基，其中如果两个C 6芳基都是苯环，则两个环之间可能有一个氧桥，与两个环上的连接相邻; A是单键或C1-3亚烷基; 并且R 5是：（i）羧基; （ii）式（II）的基团：或（iii）式（III）的基团：其中R是任选取代的C 1-7烷基，C 5-20芳基或NRN 3 R N 4，其中RN 3和RN 4独立地选自任选取代的 烷基; （ⅳ）四唑-5-基。
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公开(公告)号：US07528157B2
公开(公告)日：2009-05-05
申请号：US11615024
申请日：2006-12-22
申请人： Alexander W. Oxford , Richard J. Davis , Robert A. Coleman , Kenneth L. Clark , David E. Clark , Neil V. Harris , Garry Fenton , George Hynd , Keith A. J. Stuttle , Jonathan M. Sutton , Christopher G. Newton
发明人： Alexander W. Oxford , Richard J. Davis , Robert A. Coleman , Kenneth L. Clark , David E. Clark , Neil V. Harris , Garry Fenton , George Hynd , Keith A. J. Stuttle , Jonathan M. Sutton , Christopher G. Newton
IPC分类号： C07D307/68 , C07D405/10 , A61K31/34 , A61K31/443
CPC分类号： C07D307/54 , A61K31/34 , A61K31/341 , A61K31/4155 , A61K31/443 , C07D307/64 , C07D307/68 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O)2, or NRN1, where RN1 is selected from H or optionally substituted C1-4 alkyl, or Y is —C(═O)NRN2—, where RN2 is selected from H, and optionally substituted C1-7 alkyl or C5-20 aryl; R3 is an optionally substituted C6 aryl group linked to a further optionally substituted C6 aryl group, wherein if both C6 aryl groups are benzene rings, there may be an oxygen bridge between the two rings, bound adjacent the link on both rings; A is a single bond or a C1-3 alkylene group; and R5 is either: (i) carboxy; (ii) a group of formula (II): (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; (iv) tetrazol-5-yl.
摘要翻译： 式（I）化合物：其中：R2是H或任选取代的C 1-4烷基; Y是 - （CH 2）n X-，其中n是1或2，X是O，S，S（-O），S（-O）2或NRN1，其中RN1选自H或任选取代的C1- 4烷基或Y是-C（-O）NRN 2 - ，其中RN 2选自H，和任选取代的C 1-7烷基或C 5-20芳基; R3是与另外任意取代的C 6芳基连接的任意取代的C6芳基，其中如果两个C 6芳基都是苯环，则两个环之间可能有一个氧桥，与两个环上的连接相邻; A是单键或C1-3亚烷基; 并且R 5是：（i）羧基; （ii）式（II）的基团：（iii）式（III）的基团：其中R是任选取代的C 1-7烷基，C 5-20芳基或NRN 3 R N 4，其中RN 3和RN 4独立地选自任选取代的C 1 -4-烷基; （ⅳ）四唑-5-基。
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公开(公告)号：US07196089B2
公开(公告)日：2007-03-27
申请号：US10766030
申请日：2004-01-29
申请人： Alexander W. Oxford , Richard J. Davis , Robert A. Coleman , Kenneth L. Clark , David E. Clark , Neil V. Harris , Garry Fenton , George Hynd , Keith A. J. Stuttle , Jonathan M. Sutton , Christopher G. Newton
发明人： Alexander W. Oxford , Richard J. Davis , Robert A. Coleman , Kenneth L. Clark , David E. Clark , Neil V. Harris , Garry Fenton , George Hynd , Keith A. J. Stuttle , Jonathan M. Sutton , Christopher G. Newton
IPC分类号： A61K31/341 , A61K31/443 , A61K31/506 , C07D239/34 , C07D405/10 , C07D307/91 , C07D307/68
CPC分类号： C07D307/54 , A61K31/34 , A61K31/341 , A61K31/4155 , A61K31/443 , C07D307/64 , C07D307/68 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O)2, or NRN1, where RN1 is selected from H or optionally substituted C1-4 alkyl, or Y is —C(═O)NRN2—, where RN2 is selected from H, and optionally substituted C1-7 alkyl or C5-20 aryl; R3 is an optionally substituted C6 aryl group linked to a further optionally substituted C6 aryl group, wherein if both C6 aryl groups are benzene rings, there may be an oxygen bridge between the two rings, bound adjacent the link on both rings; A is a single bond or a C1-3 alkylene group; and R5 is either: (i) carboxy; (ii) a group of formula (II): or (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; (iv) tetrazol-5-yl.
摘要翻译： 式（I）的化合物：
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公开(公告)号：US07858644B2
公开(公告)日：2010-12-28
申请号：US12360954
申请日：2009-01-28
申请人： Alexander W. Oxford , Richard J. Davis , Robert A. Coleman , Kenneth L. Clark , David E. Clark , Neil V. Harris , Garry Fenton , George Hynd , Keith A. J. Stuttle , Jonathan M. Sutton , Christopher G. Newton
发明人： Alexander W. Oxford , Richard J. Davis , Robert A. Coleman , Kenneth L. Clark , David E. Clark , Neil V. Harris , Garry Fenton , George Hynd , Keith A. J. Stuttle , Jonathan M. Sutton , Christopher G. Newton
IPC分类号： A61K31/4418 , A61K31/422 , A61K31/34
CPC分类号： C07D307/54 , A61K31/34 , A61K31/341 , A61K31/4155 , A61K31/443 , C07D307/64 , C07D307/68 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O)2, or NRN1, where RN1 is selected from H or optionally substituted C1-4 alkyl, or Y is —C(═O)NRN2—, where RN2 is selected from H, and optionally substituted C1-7 alkyl or C5-20 aryl; R3 is an optionally substituted C6 aryl group linked to a further optionally substituted C6 aryl group, wherein if both C6 aryl groups are benzene rings, there may be an oxygen bridge between the two rings, bound adjacent the link on both rings; A is a single bond or a C1-3 alkylene group; and R5 is either: (i) carboxy; (ii) a group of formula (II): or (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted alkyl; (iv) tetrazol-5-yl.
摘要翻译： 式（I）化合物：其中：R2是H或任选取代的C 1-4烷基; Y是 - （CH 2）n -X-，其中n是1或2，X是O，S，S（= O），S（= O）2或NRN1，其中RN1选自H或任选取代 C 1-4烷基或Y是-C（= O）NRN 2 - ，其中RN 2选自H和任选取代的C 1-7烷基或C 5-20芳基; R3是与另外任意取代的C 6芳基连接的任意取代的C6芳基，其中如果两个C 6芳基都是苯环，则两个环之间可能有一个氧桥，与两个环上的连接相邻; A是单键或C1-3亚烷基; 并且R 5是：（i）羧基; （ii）式（II）的基团：或（iii）式（III）的基团：其中R是任选取代的C 1-7烷基，C 5-20芳基或NRN 3 R N 4，其中RN 3和RN 4独立地选自任选取代的 烷基; （ⅳ）四唑-5-基。
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公开(公告)号：US07507754B2
公开(公告)日：2009-03-24
申请号：US11889570
申请日：2007-08-14
申请人： Alexander W. Oxford , Richard J. Davis , Robert A. Coleman , Kenneth L. Clark , David E. Clark , Neil V. Harris , Garry Fenton , George Hynd , Keith A. J. Stuttle , Jonathan M. Sutton , Christopher G. Newton
发明人： Alexander W. Oxford , Richard J. Davis , Robert A. Coleman , Kenneth L. Clark , David E. Clark , Neil V. Harris , Garry Fenton , George Hynd , Keith A. J. Stuttle , Jonathan M. Sutton , Christopher G. Newton
IPC分类号： A61K31/443 , A61K31/343 , A61K31/341 , C07D405/12 , C07D307/91 , C07D307/68
CPC分类号： C07D307/54 , A61K31/34 , A61K31/341 , A61K31/4155 , A61K31/443 , C07D307/64 , C07D307/68 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O)2, or NRN1, where RN1 is selected from H or optionally substituted C1-4 alkyl, or Y is —C(═O)NRN2—, where RN2 is selected from H, and optionally substituted C1-7 alkyl or C5-20 aryl; R3 is an optionally substituted C6 aryl group linked to a further optionally substituted C6 aryl group, wherein if both C6 aryl groups are benzene rings, there may be an oxygen bridge between the two rings, bound adjacent the link on both rings; A is a single bond or a C1-3 alkylene group; and R5 is either: (i) carboxy; (ii) a group of formula (II): (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; (iv) tetrazol-5-yl.
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公开(公告)号：US08944128B2
公开(公告)日：2015-02-03
申请号：US13532729
申请日：2012-06-25
申请人： Michael L. Glain , David J. Kehrl , Andrew E. Modin , Scott A. Harris , Robert A. Coleman , Andrew Head , Steven C. Stenard , Thomas R. Cundiff , Joo Hyun Han , Timothy D. Aquino
发明人： Michael L. Glain , David J. Kehrl , Andrew E. Modin , Scott A. Harris , Robert A. Coleman , Andrew Head , Steven C. Stenard , Thomas R. Cundiff , Joo Hyun Han , Timothy D. Aquino
摘要： An apparatus for tensioning a preform may include a mandrel to receive a preform. The mandrel may have a first mandrel end and a second mandrel end. The preform may have a first preform end and a second preform end. The apparatus may include an anchoring groove disposed at the first mandrel end, and an anchoring device being configured and located to urge the first preform end towards the anchoring groove to secure the first preform end therebetween. The apparatus may include a tensioning groove disposed between the first mandrel end and the second mandrel end, and a tensioning device being configured and located to urge at least a portion of the preform into the tensioning groove.
摘要翻译： 用于张紧预成型件的装置可以包括用于容纳预成型件的心轴。 心轴可以具有第一心轴端部和第二心轴端部。 预成型件可以具有第一预制件端部和第二预制件端部。 该设备可以包括设置在第一心轴端处的锚定槽，以及锚定装置，其被构造和定位成将第一预制件端朝向锚固槽推动以将第一预制件端部固定在其间。 该装置可以包括设置在第一心轴端和第二心轴端之间的张紧槽，以及构造和定位的张紧装置，以将预成型件的至少一部分推入张紧槽。
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公开(公告)号：US20080283177A1
公开(公告)日：2008-11-20
申请号：US11633075
申请日：2006-12-04
申请人： Michael L. Glain , David J. Kehrl , Andrew E. Modin , Scott A. Harris , Robert A. Coleman , Andrew Head , Steven C. Stenard , Thomas R. Cundiff , Joo Hyun Han , Timothy D. Aquino
发明人： Michael L. Glain , David J. Kehrl , Andrew E. Modin , Scott A. Harris , Robert A. Coleman , Andrew Head , Steven C. Stenard , Thomas R. Cundiff , Joo Hyun Han , Timothy D. Aquino
摘要： An apparatus to prepare a preform for fabrication includes a mandrel, anchoring groove, anchoring device, tensioning groove, and tensioning device. The mandrel receives the preform. The mandrel has a first mandrel end and a second mandrel end. The preform has a first preform end and a second preform end. The anchoring groove is disposed at the first mandrel end. The anchoring device is configured and located to urge the first preform end towards the anchoring groove to secure the first preform end therebetween. The tensioning groove is disposed between the first mandrel end and the second mandrel end. The tensioning device is configured and located to urge a portion of the preform into the tensioning groove.
摘要翻译： 制备用于制造的预成型件的装置包括心轴，锚定槽，锚定装置，张紧槽和张紧装置。 心轴接收预制件。 心轴具有第一心轴端和第二心轴端。 预成型件具有第一预制件端部和第二预制件端部。 锚定槽设置在第一心轴端。 锚定装置被构造和定位成将第一预制件端部朝向锚固槽推动以将第一预制件端部固定在其间。 张紧槽设置在第一心轴端和第二心轴端之间。 张紧装置被构造和定位成将预成型件的一部分推入张紧槽。
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公开(公告)号：US07862767B2
公开(公告)日：2011-01-04
申请号：US12750182
申请日：2010-03-30
申请人： Robert A. Coleman , Timothy D. King
发明人： Robert A. Coleman , Timothy D. King
IPC分类号： B29C43/02
摘要： An apparatus and method for tensioning material (12) over a mold (14), such as a cure tool, comprises a tensioning fork (10) consisting of two substantially parallel tapered legs (18,20) between which material (12) is disposed. A tensioning fork (10) is positioned at a first side edge (42) and proximate a first end edge (38) of the material (12). A first leg (18) of the tensioning fork (10) is disposed under the material (12), and a second leg (20) of the tensioning fork (10) is disposed over the material (12). When force is applied to the second leg (20), it pivots about the first leg (18) along the length of the legs, remaining parallel to the first leg (18), thereby pressing a portion of the material (12) against the mold (14).
摘要翻译： 用于在诸如固化工具的模具（14）上张紧材料（12）的装置和方法包括由两个基本上平行的锥形支脚（18,20）组成的张紧叉（10），材料（12）设置在其间 。 张紧叉（10）定位在第一侧边缘（42）处并且靠近材料（12）的第一端边缘（38）。 张紧叉（10）的第一腿（18）设置在材料（12）的下方，并且张紧叉（10）的第二腿（20）设置在材料（12）上。 当力施加到第二腿部20上时，其沿着腿部的长度围绕第一腿部18枢转，保持平行于第一腿部18，从而将部分材料（12）压靠在第一腿部18上。 模具（14）。
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公开(公告)号：US07717694B2
公开(公告)日：2010-05-18
申请号：US11853660
申请日：2007-09-11
申请人： Robert A. Coleman , Timothy D. King
发明人： Robert A. Coleman , Timothy D. King
IPC分类号： B29C43/36
摘要： An apparatus and method for tensioning material (12) over a mold (14), such as a cure tool, comprises a tensioning fork (10) consisting of two substantially parallel tapered legs (18,20) between which material (12) is disposed. A tensioning fork (10) is positioned at a first side edge (42) and proximate a first end edge (38) of the material (12). A first leg (18) of the tensioning fork (10) is disposed under the material (12), and a second leg (20) of the tensioning fork (10) is disposed over the material (12). When force is applied to the second leg (20), it pivots about the first leg (18) along the length of the legs, remaining parallel to the first leg (18), thereby pressing a portion of the material (12) against the mold (14).
摘要翻译： 用于在诸如固化工具的模具（14）上张紧材料（12）的装置和方法包括由两个基本上平行的锥形支脚（18,20）组成的张紧叉（10），材料（12）设置在其间 。 张紧叉（10）定位在第一侧边缘（42）处并且靠近材料（12）的第一端边缘（38）。 张紧叉（10）的第一腿（18）设置在材料（12）的下方，并且张紧叉（10）的第二腿（20）设置在材料（12）上。 当力施加到第二腿部20上时，其沿着腿部的长度围绕第一腿部18枢转，保持平行于第一腿部18，从而将部分材料（12）压靠在第一腿部18上。 模具（14）。
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公开(公告)号：US08303757B2
公开(公告)日：2012-11-06
申请号：US11633075
申请日：2006-12-04
申请人： Michael L. Glain , David J. Kehrl , Andrew E. Modin , Scott A. Harris , Robert A. Coleman , Andrew Head , Steven C. Stenard , Thomas R. Cundiff , Joo Hyun Han , Timothy D. Aquino
发明人： Michael L. Glain , David J. Kehrl , Andrew E. Modin , Scott A. Harris , Robert A. Coleman , Andrew Head , Steven C. Stenard , Thomas R. Cundiff , Joo Hyun Han , Timothy D. Aquino
摘要： An apparatus to prepare a preform for fabrication includes a mandrel, anchoring groove, anchoring device, tensioning groove, and tensioning device. The mandrel receives the preform. The mandrel has a first mandrel end and a second mandrel end. The preform has a first preform end and a second preform end. The anchoring groove is disposed at the first mandrel end. The anchoring device is configured and located to urge the first preform end towards the anchoring groove to secure the first preform end therebetween. The tensioning groove is disposed between the first mandrel end and the second mandrel end. The tensioning device is configured and located to urge a portion of the preform into the tensioning groove.
摘要翻译： 制备用于制造的预成型件的装置包括心轴，锚定槽，锚定装置，张紧槽和张紧装置。 心轴接收预制件。 心轴具有第一心轴端和第二心轴端。 预成型件具有第一预制件端部和第二预制件端部。 锚定槽设置在第一心轴端。 锚定装置被构造和定位成将第一预制件端部朝向锚固槽推动以将第一预制件端部固定在其间。 张紧槽设置在第一心轴端和第二心轴端之间。 张紧装置被构造和定位成将预成型件的一部分推入张紧槽。
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