公开(公告)号：US20100056790A1

公开(公告)日：2010-03-04

申请号：US12621464

申请日：2009-11-18

申请人： Alexey Aksinenko ,  Sergey Bachurin ,  Sergey Sablin ,  Bogdan Beznosko ,  Nadezhda Beznosko ,  Vladimir Sokolov

发明人： Alexey Aksinenko ,  Sergey Bachurin ,  Sergey Sablin ,  Bogdan Beznosko ,  Nadezhda Beznosko ,  Vladimir Sokolov

IPC分类号： C07D471/02

CPC分类号： C07D471/04

摘要： Some exemplary embodiments comprise fluoro-containing derivatives of pyrido[4,3-b]indoles (and exemplary methods of making the same) that may be administered to a mammal (including a human) in an effective amount for potential use in the treatment or prophylaxis of neurological disorders including AD, mild cognitive impairment, senile and vascular dementia, HD, ALS, Parkinson's disease, AIDS-related dementia, ischaemic cerebral pathologies, neuropathic pain, ADHD (attention deficit disorder/hyperactivity syndrome), eating disorders such as anorexia and bulimia, panic attacks, withdrawal from drug abuse such as cocaine, ethanol, nicotine and benzodiazepines, schizophrenia (in particular the cognitive deficit of schizophrenia), stroke and also disorders associated with spinal trauma and/or head injury. These derivatives may also be useful for the treatment of borderline personality disorder, obesity, and for use as geroprotectors. The compounds may also be used as “pharmacological tools” for an investigation of the mechanism of protection against neurodegeneration disorders in vivo or in vitro.

摘要翻译： 一些示例性实施方案包括吡啶并[4,3-b]吲哚的含氟衍生物（和其制备方法），其可以有效量施用于哺乳动物（包括人）用于治疗或 预防神经系统疾病，包括AD，轻度认知障碍，老年和血管性痴呆，HD，ALS，帕金森病，艾滋病相关性痴呆，缺血性脑病，神经性疼痛，ADHD（注意缺陷障碍/多动症综合征），进食障碍如厌食 贪食症，恐慌症，药物滥用如可卡因，乙醇，尼古丁和苯并二氮杂类药物，精神分裂症（特别是精神分裂症的认知缺陷），中风以及与脊髓损伤和/或头部损伤有关的疾病。 这些衍生物也可用于治疗边缘人格障碍，肥胖症和用作胃保护剂。 该化合物也可以用作“药理学工具”，用于研究在体内或体外对神经变性疾病的保护机​​制。

公开(公告)号：US07935823B2

公开(公告)日：2011-05-03

申请号：US12621464

申请日：2009-11-18

申请人： Alexey Aksinenko ,  Sergey Bachurin ,  Sergey Sablin ,  Bogdan Beznosko ,  Nadezhda Beznosko, legal representative ,  Julia Beznosko, legal representative ,  Vladimir Sokolov

发明人： Alexey Aksinenko ,  Sergey Bachurin ,  Sergey Sablin ,  Bogdan Beznosko ,  Vladimir Sokolov

IPC分类号： C07D471/04 ,  A61K31/437

CPC分类号： C07D471/04

摘要： Some exemplary embodiments comprise fluoro-containing derivatives of pyrido[4,3-b]indoles (and exemplary methods of making the same) that may be administered to a mammal (including a human) in an effective amount for potential use in the treatment or prophylaxis of neurological disorders including AD, mild cognitive impairment, senile and vascular dementia, HD, ALS, Parkinson's disease, AIDS-related dementia, ischaemic cerebral pathologies, neuropathic pain, ADHD (attention deficit disorder/hyperactivity syndrome), eating disorders such as anorexia and bulimia, panic attacks, withdrawal from drug abuse such as cocaine, ethanol, nicotine and benzodiazepines, schizophrenia (in particular the cognitive deficit of schizophrenia), stroke and also disorders associated with spinal trauma and/or head injury. These derivatives may also be useful for the treatment of borderline personality disorder, obesity, and for use as geroprotectors. The compounds may also be used as “pharmacological tools” for an investigation of the mechanism of protection against neurodegeneration disorders in vivo or in vitro.

摘要翻译： 一些示例性实施方案包括吡啶并[4,3-b]吲哚的含氟衍生物（和其制备方法），其可以有效量施用于哺乳动物（包括人）用于治疗或 预防神经系统疾病，包括AD，轻度认知障碍，老年和血管性痴呆，HD，ALS，帕金森病，艾滋病相关性痴呆，缺血性脑病，神经性疼痛，ADHD（注意缺陷障碍/多动症综合征），进食障碍如厌食 贪食症，恐慌症，药物滥用如可卡因，乙醇，尼古丁和苯并二氮杂类药物，精神分裂症（特别是精神分裂症的认知缺陷），中风以及与脊髓损伤和/或头部损伤有关的疾病。 这些衍生物也可用于治疗边缘人格障碍，肥胖症和用作胃保护剂。 该化合物也可以用作“药理学工具”，用于研究在体内或体外对神经变性疾病的保护机​​制。

公开(公告)号：US20100105912A1

公开(公告)日：2010-04-29

申请号：US12687854

申请日：2010-01-14

申请人： Alexey Aksinenko ,  Sergey Bachurin ,  Sergey Sablin ,  Bogdan Beznosko ,  Vladimir Sokolov ,  Bogdan Beznosko

发明人： Alexey Aksinenko ,  Sergey Bachurin ,  Sergey Sablin ,  Bogdan Beznosko ,  Vladimir Sokolov ,  Bogdan Beznosko

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： Some exemplary embodiments comprise fluoro-containing derivatives of pyrido[4,3-b]indoles (and exemplary methods of making the same) that may be administered to a mammal (including a human) in an effective amount for potential use in the treatment or prophylaxis of neurological disorders including AD, mild cognitive impairment, senile and vascular dementia, HD, ALS, Parkinson's disease, AIDS-related dementia, ischaemic cerebral pathologies, neuropathic pain, ADHD (attention deficit disorder/hyperactivity syndrome), eating disorders such as anorexia and bulimia, panic attacks, withdrawal from drug abuse such as cocaine, ethanol, nicotine and benzodiazepines, schizophrenia (in particular the cognitive deficit of schizophrenia), stroke and also disorders associated with spinal trauma and/or head injury. These derivatives may also be useful for the treatment of borderline personality disorder, obesity, and for use as geroprotectors. The compounds may also be used as “pharmacological tools” for an investigation of the mechanism of protection against neurodegeneration disorders in vivo or in vitro.

摘要翻译： 一些示例性实施方案包括吡啶并[4,3-b]吲哚的含氟衍生物（和其制备方法），其可以有效量施用于哺乳动物（包括人）用于治疗或 预防神经系统疾病，包括AD，轻度认知障碍，老年和血管性痴呆，HD，ALS，帕金森病，艾滋病相关性痴呆，缺血性脑病，神经性疼痛，ADHD（注意缺陷障碍/多动症综合征），进食障碍如厌食 贪食症，恐慌症，药物滥用如可卡因，乙醇，尼古丁和苯并二氮杂类药物，精神分裂症（特别是精神分裂症的认知缺陷），中风以及与脊髓损伤和/或头部损伤有关的疾病。 这些衍生物也可用于治疗边缘人格障碍，肥胖症和用作胃保护剂。 该化合物也可以用作“药理学工具”，用于研究在体内或体外对神经变性疾病的保护机​​制。

公开(公告)号：US20090221627A1

公开(公告)日：2009-09-03

申请号：US12284291

申请日：2008-09-19

申请人： Alexey Aksinenko ,  Sergey Bachurin ,  Sergey Sablin ,  Bogdan Beznosko ,  Vladimir Sokolov ,  Nadezhcla Besnosko ,  Julia Beznosko

发明人： Alexey Aksinenko ,  Sergey Bachurin ,  Sergey Sablin ,  Bogdan Beznosko ,  Vladimir Sokolov ,  Nadezhcla Besnosko ,  Julia Beznosko

IPC分类号： A61K31/437 ,  A61K31/4353 ,  A61K31/13 ,  C07D471/04

CPC分类号： C07D471/04

摘要： Some exemplary embodiments comprise fluoro-containing derivatives of pyrido[4,3-b]indoles (and exemplary methods of making the same) that may be administered to a mammal (including a human) in an effective amount for potential use in the treatment or prophylaxis of neurological disorders including AD, mild cognitive impairment, senile and vascular dementia, HD, ALS, Parkinson's disease, AIDS-related dementia, ischaemic cerebral pathologies, neuropathic pain, ADHD (attention deficit disorder/hyperactivity syndrome), eating disorders such as anorexia and bulimia, panic attacks, withdrawal from drug abuse such as cocaine, ethanol, nicotine and benzodiazepines, schizophrenia (in particular the cognitive deficit of schizophrenia), stroke and also disorders associated with spinal trauma and/or head injury. These derivatives may also be useful for the treatment of borderline personality disorder, obesity, and for use as geroprotectors. The compounds may also be used as “pharmacological tools” for an investigation of the mechanism of protection against neurodegeneration disorders in vivo or in vitro.

摘要翻译： 一些示例性实施方案包括吡啶并[4,3-b]吲哚的含氟衍生物（和其制备方法），其可以有效量施用于哺乳动物（包括人）用于治疗或 预防神经系统疾病，包括AD，轻度认知障碍，老年和血管性痴呆，HD，ALS，帕金森病，艾滋病相关性痴呆，缺血性脑病，神经性疼痛，ADHD（注意缺陷障碍/多动症综合征），进食障碍如厌食 贪食症，恐慌症，药物滥用如可卡因，乙醇，尼古丁和苯并二氮杂类药物，精神分裂症（特别是精神分裂症的认知缺陷），中风以及与脊髓损伤和/或头部损伤有关的疾病。 这些衍生物也可用于治疗边缘人格障碍，肥胖症和用作胃保护剂。 该化合物也可以用作“药理学工具”，用于研究在体内或体外对神经变性疾病的保护机​​制。

公开(公告)号：US20130101030A1

公开(公告)日：2013-04-25

申请号：US13341464

申请日：2011-12-30

申请人： Pontus Carlsson ,  Andrei Jefremov ,  Sergey Sablin ,  David Zhao

发明人： Pontus Carlsson ,  Andrei Jefremov ,  Sergey Sablin ,  David Zhao

IPC分类号： H04N7/26

CPC分类号： H04N19/58 ,  H04N19/423 ,  H04N19/46 ,  H04N19/573 ,  H04N19/70

摘要： In an embodiment, a method of transmitting video data includes at an encoder encoding the video data as a plurality of frames, including reference frames and intermediate frames, at least some of which are encoded based on multiple reference frames; at the encoder maintaining for each frame a current list of reference frames; and transmitting the plurality of frames, each frame being transmitted in association with a current list of reference frames for that frame.

摘要翻译： 在一个实施例中，传输视频数据的方法包括编码视频数据作为多个帧的编码器，包括参考帧和中间帧，其中至少一些基于多个参考帧进行编码; 在编码器处为每个帧维护参考帧的当前列表; 并且发送多个帧，每个帧与该帧的参考帧的当前列表相关联地发送。

公开(公告)号：US20130093906A1

公开(公告)日：2013-04-18

申请号：US13339879

申请日：2011-12-29

申请人： Pontus Carlsson ,  Andrei Jefremov ,  Sergey Sablin ,  David Zhao

发明人： Pontus Carlsson ,  Andrei Jefremov ,  Sergey Sablin ,  David Zhao

IPC分类号： H04N5/228

CPC分类号： H04N5/23248 ,  H04N5/23258 ,  H04N5/23267

摘要： Method, device and computer program product for stabilizing a received video signal. A plurality of frames of the video signal is captured using a camera. The video signal is transmitted as an encoded bit stream. Displacement of the camera between successive frames is determined from a motion indication in the bit stream. The determined displacement is used to compensate for motion in the video signal between successive frames caused by the motion of the camera, to thereby stabilize the video signal.

摘要翻译： 用于稳定接收到的视频信号的方法，设备和计算机程序产品。 使用照相机拍摄视频信号的多个帧。 视频信号作为编码比特流发送。 摄像机在连续帧之间的位移由比特流中的运动指示确定。 确定的位移用于补偿由相机的运动引起的连续帧之间的视频信号中的运动，从而稳定视频信号。

公开(公告)号：US20120219067A1

公开(公告)日：2012-08-30

申请号：US13295737

申请日：2011-11-14

申请人： Andrei Jefremov ,  David Zhao ,  Sergey Sablin

发明人： Andrei Jefremov ,  David Zhao ,  Sergey Sablin

IPC分类号： H04N7/26

CPC分类号： H04N19/58 ,  H04N19/105 ,  H04N19/164 ,  H04N19/172 ,  H04N19/174 ,  H04N19/176 ,  H04N19/46 ,  H04N19/61 ,  H04N19/89

摘要： An encoder allocates index numbers to portions of a video signal transmitted over a network to a decoder. At least some of the portions are stored in an encoder buffer. Feedback is received from the network at a remote control block, indicating whether the transmitted portions are correctly received. Based on the feedback, the control block determines a subset of the portions stored in the buffer. The control block transmits a message to the encoder, identifying the subset using the index numbers allocated to the portions in the subset. In response, the encoder uses the index numbers to identify and retrieve at least one portion of the subset of portions from the buffer, the retrieved portion is used to encode subsequent portions of the signal.

摘要翻译： 编码器将索引编号分配给通过网络发送到解码器的视频信号的部分。 至少部分部分存储在编码器缓冲器中。 在远程控制块处从网络接收到反馈，指示发送的部分是否被正确接收。 基于反馈，控制块确定存储在缓冲器中的部分的子集。 控制块向编码器发送消息，使用分配给子集中的部分的索引号来识别子集。 作为响应，编码器使用索引号从缓冲器中识别和检索部分子集的至少一部分，所检索的部分用于编码信号的后续部分。

公开(公告)号：US09762799B2

公开(公告)日：2017-09-12

申请号：US13339879

申请日：2011-12-29

申请人： Pontus Carlsson ,  Andrei Jefremov ,  Sergey Sablin ,  David Zhao

发明人： Pontus Carlsson ,  Andrei Jefremov ,  Sergey Sablin ,  David Zhao

IPC分类号： H04N5/232

CPC分类号： H04N5/23248 ,  H04N5/23258 ,  H04N5/23267

摘要： Method, device and computer program product for stabilizing a received video signal. A plurality of frames of the video signal is captured using a camera. The video signal is transmitted as an encoded bit stream. Displacement of the camera between successive frames is determined from a motion indication in the bit stream. The determined displacement is used to compensate for motion in the video signal between successive frames caused by the motion of the camera, to thereby stabilize the video signal.

公开(公告)号：US20130259114A1

公开(公告)日：2013-10-03

申请号：US13536346

申请日：2012-06-28

申请人： Pontus Carlsson ,  Andrei Jefremov ,  Sergey Sablin ,  David Zhao

发明人： Pontus Carlsson ,  Andrei Jefremov ,  Sergey Sablin ,  David Zhao

IPC分类号： H04N11/02

CPC分类号： H04N19/167 ,  H04N19/124 ,  H04N19/17 ,  H04N19/46

摘要： The invention relates to a method of encoding a video stream comprising, receiving a video signal comprising a plurality of frames, each frame comprising one or more portion of video data displaying to a user a video image derived from the video signal; receiving from the user selection of at least one region in the video image, the region represented by a portion of video data; and encoding the video signal, said encoding comprising encoding the portion of video data corresponding to the at least one selected region at a higher quality level than other portions of the video data in the video stream.

摘要翻译： 本发明涉及一种对视频流进行编码的方法，包括：接收包括多个帧的视频信号，每个帧包括视频数据的一个或多个部分向用户显示从视频信号导出的视频图像; 从所述用户接收所述视频图像中的至少一个区域的选择，所述区域由视频数据的一部分表示; 并且对所述视频信号进行编码，所述编码包括以与所述视频流中的视频数据的其他部分相比更高的质量水平对与所述至少一个所选区域相对应的视频数据的部分进行编码。