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    AGER-peptides and use thereof
    1.
    发明授权
    AGER-peptides and use thereof 有权
    AGER-肽及其用途

    公开(公告)号：US09291621B2

    公开(公告)日：2016-03-22

    申请号：US11795282

    申请日：2006-01-18

    申请人： Alfred Hahn ,  Ralf Loebbert ,  Nicole Teusch ,  Achim Möller ,  Ulrich Ebert ,  Martin Schmidt

    发明人： Alfred Hahn ,  Ralf Loebbert ,  Nicole Teusch ,  Achim Möller ,  Ulrich Ebert ,  Martin Schmidt

    IPC分类号： A61K39/00 ,  G01N33/564 ,  C07K16/28

    CPC分类号： C07K16/2803 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K7/08 ,  C07K2317/24 ,  C12N15/85 ,  C12P21/005 ,  C12P21/02 ,  G01N33/564 ,  G01N33/566 ,  G01N2333/70503 ,  G01N2500/00

    摘要： The present invention relates to the identification, functionality and use of domains from the N terminus of the receptor for Advanced Glycation End Products (AGER). These domains, called receptor multimerization epitope (RME), are highly conserved in all AGER protein sequences. They represent the mediators for AGER self-association and heteromerization with other proteins. The invention likewise relates to the identification, functionality and use of peptides derived from the C domain of AGER (AGER-CDP). The AGER RMEs and AGER-CDPs of the invention are suitable as target for identifying AGER ligands which modulate the natural ligand interaction; as immunogen for active or passive immunization of individuals, as diagnostic means for identifying immunogenic reactions, and as peptide ligands for modulating protein-protein interactions involving AGER.

    摘要翻译： 本发明涉及来自高级糖化终产物（AGER）的受体的N末端的结构域的鉴定，功能和用途。 称为受体多聚表位（RME）的这些结构域在所有AGER蛋白质序列中都是高度保守的。 它们代表AGER与其他蛋白质自身结合和异源化的介质。 本发明同样涉及衍生自AGER（AGER-CDP）的C结构域的肽的鉴定，功能和用途。 本发明的AGER RME和AGER-CDP适用于鉴定调节天然配体相互作用的AGER配体的靶标; 作为用于个体的主动或被动免疫的免疫原，作为用于鉴定免疫原性反应的诊断手段，以及用于调节涉及AGER的蛋白质 - 蛋白质相互作用的肽配体。

    AGER-Peptides and Use Thereof
    2.
    发明申请
    AGER-Peptides and Use Thereof 有权
    AGER-肽及其用途

    公开(公告)号：US20100226915A1

    公开(公告)日：2010-09-09

    申请号：US11795282

    申请日：2006-01-18

    申请人： Alfred Hahn ,  Ralph Loebbert ,  Nicole Teusch ,  Achim Möller

    发明人： Alfred Hahn ,  Ralph Loebbert ,  Nicole Teusch ,  Achim Möller

    IPC分类号： A61K39/395 ,  C07K16/18 ,  G01N33/566 ,  A61K39/00 ,  A61K31/7088 ,  A61K38/43 ,  C12N15/63 ,  C12N1/00 ,  C12N5/16 ,  C12P21/06 ,  C07K14/00

    CPC分类号： C07K16/2803 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K7/08 ,  C07K2317/24 ,  C12N15/85 ,  C12P21/005 ,  C12P21/02 ,  G01N33/564 ,  G01N33/566 ,  G01N2333/70503 ,  G01N2500/00

    摘要： The present invention relates to the identification, functionality and use of domains from the N terminus of the receptor for Advanced Glycation End Products (AGER). These domains, called receptor mulitimerization epitope (RME), are highly conserved in all AGER protein sequences. They represent the mediators for AGER self-association and heteromerization with other proteins. The invention likewise relates to the identification, functionality and use of peptides derived from the C domain of AGER (AGER-CDP). The AGER RMEs and AGER-CDPs of the invention are suitable as target for identifying AGER ligands which modulate the natural ligand interaction; as immunogen for active or passive immunization of individuals, as diagnostic means for identifying immunogenic reactions, and as peptide ligands for modulating protein-protein interactions involving AGER.

    摘要翻译： 本发明涉及来自高级糖化终产物（AGER）的受体的N末端的结构域的鉴定，功能和用途。 称为受体多聚表位（RME）的这些结构域在所有AGER蛋白质序列中都是高度保守的。 它们代表AGER与其他蛋白质自身结合和异源化的介质。 本发明同样涉及衍生自AGER（AGER-CDP）的C结构域的肽的鉴定，功能和用途。 本发明的AGER RME和AGER-CDP适用于鉴定调节天然配体相互作用的AGER配体的靶标; 作为用于个体的主动或被动免疫的免疫原，作为用于鉴定免疫原性反应的诊断手段，以及用于调节涉及AGER的蛋白质 - 蛋白质相互作用的肽配体。

    Patient support apparatus for medical examinations
    6.
    发明授权
    Patient support apparatus for medical examinations 失效
    用于体格检查的患者支持装置

    公开(公告)号：US5361436A

    公开(公告)日：1994-11-08

    申请号：US107057

    申请日：1993-08-17

    申请人： Alfred Hahn

    发明人： Alfred Hahn

    IPC分类号： A61B6/04 ,  A61G13/02 ,  A61G7/00 ,  A61G13/00

    CPC分类号： A61G13/02 ,  A61B6/04

    摘要： A support apparatus for supporting and positioning a patient during a medical examination includes a patient support plate and a combination of elements for lifting and pivoting the support plate which operate to pivot the support plate around a stationary, virtual (i.e., non-load bearing) axis disposed at an end region of the support plate.

    摘要翻译： 用于在医学检查期间支撑和定位患者的支撑装置包括患者支撑板和用于提升和枢转支撑板的元件的组合，所述支撑板用于使支撑板绕静止的虚拟（即，非负载） 轴设置在支撑板的端部区域。

    Apparatus for contactless fragmentation of concrements in vivo
    7.
    发明授权
    Apparatus for contactless fragmentation of concrements in vivo 失效
    用于体内不规则碎片化的装置

    公开(公告)号：US4655220A

    公开(公告)日：1987-04-07

    申请号：US694578

    申请日：1985-01-24

    申请人： Alfred Hahn ,  George Vogel

    发明人： Alfred Hahn ,  George Vogel

    IPC分类号： A61B17/22 ,  G10K9/12

    CPC分类号： G10K9/12

    摘要： The invention relates to an apparatus for the contactless fragmentation of a concrement present in the body of a living being. A shock wave generator is aimed at a target region in the body and includes a coil having the form of a spherical segment. In front of the coil is arranged a mating radiator element, which closes off a liquid filled space and generates therein a shock wave focused on the centers of curvature of the coil and element upon brief connection of the coil to a high voltage. The concrement to be fragmented is positioned to lie at these centers of curvature.

    摘要翻译： 本发明涉及一种用于存在于生物体内的混凝土的非接触碎裂的装置。 冲击波发生器瞄准身体中的目标区域，并且包括具有球形段形式的线圈。 在线圈的前面设置有配合的散热器元件，其将液体填充的空间封闭，并且在将线圈短暂连接到高电压时在其中产生聚焦在线圈和元件的曲率中心上的冲击波。 要分段的混凝土位于这些曲率中心。

    Primary-beam collimator for stereo radiographic x-ray diagnostic apparatus
    8.
    发明授权
    Primary-beam collimator for stereo radiographic x-ray diagnostic apparatus 失效
    用于立体放射X光诊断仪的一次射束准直仪

    公开(公告)号：US4641335A

    公开(公告)日：1987-02-03

    申请号：US720321

    申请日：1985-04-05

    申请人： Alfred Hahn

    发明人： Alfred Hahn

    IPC分类号： G21K1/04 ,  A61B6/02 ,  A61B6/06 ,  A61B6/08 ,  G21K1/02

    CPC分类号： A61B6/022 ,  A61B6/06 ,  A61B6/08 ,  G21K1/02

    摘要： A primary-beam collimator for a stereo radiographic x-ray diagnostic installation has an x-ray tube with dual focal points (F1, F2) arranged at a distance from each other. Shutter leaves (1a, 1b, 2a, 2b, 3a, 3b, 4a, 4b) are provided, and adjustable so that two beam pyramids (I from focal point F1, and II from focal point F2) can be individually controlled. Two internal shutter leaves (4a, 4b) are provided for restricting the beam in planes perpendicular to the stereo base F1-F2. These are adjustable between two external shutter leaves--each in the direction of its corresponding external shutter leaf. The internal shutter leaves (4a, 4b) are constructed so that, when adjusted to their external positions, they permit the emission of a central beam-pyramid from a central focal point (FN) and, together with the external shutter leaves (2a, 2b), they close the external shutter openings.

    摘要翻译： 用于立体放射X射线诊断装置的一次束准直仪具有配置为彼此距离的双焦点（F1，F2）的X射线管。 提供了快门叶片（1a，1b，2a，2b，3a，3b，4a，4b），并且可调节，使得可以单独地控制两个横梁金字塔（来自焦点F1的I和来自焦点F2的II）。 提供两个内部快门叶片（4a，4b），用于在垂直于立体基座F1-F2的平面中限制光束。 这些可以在两个外部快门叶片之间调节，每个叶片沿相应的外部快门叶片的方向。 内部快门叶片（4a，4b）被构造成使得当调节到其外部位置时，它们允许从中心焦点（FN）发射中心束 - 金字塔，并且与外部快门叶片（2a， 2b），它们关闭外部闸门开口。

    Patient support table
    9.
    发明授权
    Patient support table 失效
    病人支持表

    公开(公告)号：US4582310A

    公开(公告)日：1986-04-15

    申请号：US670048

    申请日：1984-11-09

    申请人： Alfred Hahn

    发明人： Alfred Hahn

    IPC分类号： A61G13/06 ,  B66F7/06 ,  A61G13/00

    CPC分类号： B66F7/065 ,  A61G13/06 ,  A61G2210/50

    摘要： An x-ray examination table having a trestle on which a patient support platform is height-adjustably mounted, characterized by the trestle having a liftable member on which the table is mounted being connected to a base by a double-jointed support arrangement and being movable to the base by a lifting arrangement. The double-jointed support arrangement includes a pair of brackets pivotally connected together and having one of the pair being pivotally connected to the liftable member and the other being pivotally connected to the base. The pivotal connections are shafts which extend parallel to each other for each linkage arrangement and perpendicular to the shafts of the adjacent linkage arrangement so that the double-jointed supports guide the liftable member as it is moved between the upper and lowermost positions.

    摘要翻译： 一种具有托架的X射线检查台，患者支撑平台可高度可调节地安装在该支架上，其特征在于，所述支架具有其上安装有所述工作台的可升降构件，其通过双重接合的支撑装置连接到基座并且可移动 通过提升安排到基地。 双接头支撑装置包括一对托架，其枢转地连接在一起，并且一对托架枢转地连接到可升降构件，另一个枢转地连接到基座。 枢转连接是针对每个联动装置彼此平行地延伸并且垂直于相邻联动装置的轴的轴，使得双重接合的支承件在可升降构件在上下位置之间移动时引导可升降构件。