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1.发明授权Compounds and methods for inhibiting the interaction of BCL proteins with binding partners 失效抑制BCL蛋白与结合配偶体相互作用的化合物和方法公开(公告)号：US08609706B2
公开(公告)日：2013-12-17
申请号：US13472136
申请日：2012-05-15
申请人： Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence Blas Perez , Daniel A. Snyder , Thomas T. Tibbitts
发明人： Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence Blas Perez , Daniel A. Snyder , Thomas T. Tibbitts
IPC分类号： A61K31/42 , C07D261/02
CPC分类号： C07D261/02 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D413/10 , C07D413/12 , C07D417/12
摘要： The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.
摘要翻译： 本发明涉及与bcl蛋白结合并抑制Bcl功能的含异唑烷的化合物。 该化合物可用于治疗和调节与过度增生相关的疾病，例如癌症。
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2.发明申请Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners 失效抑制BCL蛋白与结合伙伴相互作用的化合物和方法公开(公告)号：US20130131063A1
公开(公告)日：2013-05-23
申请号：US13472136
申请日：2012-05-15
申请人： Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence Blas Perez , Daniel A. Snyder , Thomas T. Tibbitts
发明人： Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence Blas Perez , Daniel A. Snyder , Thomas T. Tibbitts
IPC分类号： C07D261/02 , C07D417/12 , A61K31/5377 , A61K31/454 , A61K31/496 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , C07D413/10 , C07D413/12 , A61K45/06
CPC分类号： C07D261/02 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D413/10 , C07D413/12 , C07D417/12
摘要： The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.
摘要翻译： 本发明涉及与bcl蛋白结合并抑制Bcl功能的含异唑烷的化合物。 该化合物可用于治疗和调节与过度增生相关的疾病，例如癌症。
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3.发明授权Compounds and methods for inhibiting the interaction of BCL proteins with binding partners 有权抑制BCL蛋白与结合配偶体相互作用的化合物和方法公开(公告)号：US08178690B2
公开(公告)日：2012-05-15
申请号：US13089530
申请日：2011-04-19
申请人： Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence Blas Perez , Daniel A. Snyder , Thomas T. Tibbitts
发明人： Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence Blas Perez , Daniel A. Snyder , Thomas T. Tibbitts
IPC分类号： C07D261/02 , A61K31/42
CPC分类号： C07D261/02 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D413/10 , C07D413/12 , C07D417/12
摘要： The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.
摘要翻译： 本发明涉及与bcl蛋白结合并抑制Bcl功能的含异唑烷的化合物。 该化合物可用于治疗和调节与过度增生相关的疾病，例如癌症。
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4.发明授权Compounds and methods for inhibiting the interaction of BCL proteins with binding partners 有权抑制BCL蛋白与结合配偶体相互作用的化合物和方法公开(公告)号：US07928244B2
公开(公告)日：2011-04-19
申请号：US11842581
申请日：2007-08-21
申请人： Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence B. Perez , Daniel A. Snyder , Thomas T. Tibbitts
发明人： Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence B. Perez , Daniel A. Snyder , Thomas T. Tibbitts
IPC分类号： C07D261/02 , A61K31/42
CPC分类号： C07D261/02 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D413/10 , C07D413/12 , C07D417/12
摘要： The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.
摘要翻译： 本发明涉及与bcl蛋白结合并抑制Bcl功能的含异唑烷的化合物。 该化合物可用于治疗和调节与过度增生相关的疾病，例如癌症。
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5.发明申请Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners 有权抑制BCL蛋白与结合伙伴相互作用的化合物和方法公开(公告)号：US20110213145A1
公开(公告)日：2011-09-01
申请号：US13089530
申请日：2011-04-19
申请人： Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence B. Perez , Daniel A. Snyder , Thomas T. Tibbitts
发明人： Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence B. Perez , Daniel A. Snyder , Thomas T. Tibbitts
IPC分类号： C07D413/12 , C07D413/10 , C07D261/02 , C07D498/04
CPC分类号： C07D261/02 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D413/10 , C07D413/12 , C07D417/12
摘要： The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.
摘要翻译： 本发明涉及与bcl蛋白结合并抑制Bcl功能的含异唑烷的化合物。 该化合物可用于治疗和调节与过度增生相关的疾病，例如癌症。
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6.发明授权Compounds and methods for inhibiting the interaction of BCL proteins with binding partners 有权抑制BCL蛋白与结合配偶体相互作用的化合物和方法公开(公告)号：US07851637B2
公开(公告)日：2010-12-14
申请号：US11156364
申请日：2005-06-17
申请人： Alfredo C. Castro , Wei Deng , Kristopher M. Depew , Michael A. Foley , Christian C. Fritz , Asimina T. Georges Evangelinos , Michael J. Grogan , Nafeeza Hafeez , Edward B. Holson , Brian T. Hopkins , Nii O. Koney , Tao Liu , David A. Mann , Lisa A. Marcaurelle , Daniel A. Snyder , Dennis J. Underwood , Andrew A. Wylie , Lin-Chen Yu , Linping Zhang
发明人： Alfredo C. Castro , Wei Deng , Kristopher M. Depew , Michael A. Foley , Christian C. Fritz , Asimina T. Georges Evangelinos , Michael J. Grogan , Nafeeza Hafeez , Edward B. Holson , Brian T. Hopkins , Nii O. Koney , Tao Liu , David A. Mann , Lisa A. Marcaurelle , Daniel A. Snyder , Dennis J. Underwood , Andrew A. Wylie , Lin-Chen Yu , Linping Zhang
IPC分类号： C07D261/02 , A61K31/42
CPC分类号： C07D261/02 , C07D261/18 , C07D413/10 , C07D413/12 , C07D417/12 , C07D498/04
摘要： One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.
摘要翻译： 本发明的一个方面涉及结合bcl蛋白并抑制Bcl功能的杂环化合物。 本发明的另一方面涉及包含本发明的杂环化合物的组合物。 本发明提供了治疗和调节与过度增生相关的疾病如癌症的方法。
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公开(公告)号：US5951564A
公开(公告)日：1999-09-14
申请号：US769198
申请日：1996-12-18
申请人： Lisa K. Schroder , David A. Mann , G. Kris Kumar , Steven C. Kitch , Paul F. Hickey , Timothy K. Doolin , Philip H. Cripe , Kim C. Bertin
发明人： Lisa K. Schroder , David A. Mann , G. Kris Kumar , Steven C. Kitch , Paul F. Hickey , Timothy K. Doolin , Philip H. Cripe , Kim C. Bertin
CPC分类号： A61F2/4607 , A61F2/367 , A61F2002/30617 , A61F2002/30795 , A61F2002/3631 , A61F2002/365 , A61F2002/368 , A61F2002/4619 , A61F2002/4622 , A61F2002/4623 , A61F2002/4628 , A61F2002/4631 , A61F2002/4681 , A61F2250/0097
摘要： The invention is directed to an orthopaedic apparatus 24, 80, 380, 480, 580 for positioning an implant 22, 322, 422 relative to an end of a bone. The implant has at least one extractor opening 30, 330, 430 and a shoulder 26, 326, 426 with a slot therein. The positioning apparatus includes a shaft 32, 82, 382, 482 having a fixed impactor tip at an end thereof. The impactor tip is configured to be received within the implant slot. At least one clamping jaw is connected to the shaft, and includes a projection which is configured to be received in the at least one extractor opening. The at least one clamping jaw is preferably detachably connected to the shaft.
摘要翻译： 本发明涉及一种用于相对于骨的端部定位植入物22,322,422的整形外科装置24,80,380,480,580。 植入物具有至少一个提取器开口30,330,430以及其中具有狭槽的肩部26,326,426。 定位装置包括在其一端具有固定的冲击器尖端的轴32,82,382,482。 冲击器尖端被配置为被接收在植入槽内。 至少一个夹爪连接到轴，并且包括被配置为容纳在至少一个提取器开口中的突起。 所述至少一个夹爪优选地可拆卸地连接到所述轴。
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公开(公告)号：USD397220S
公开(公告)日：1998-08-18
申请号：US52628
申请日：1996-03-28
申请人： G. Kris Kumar , David A. Mann
设计人： G. Kris Kumar , David A. Mann
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公开(公告)号：US06842964B1
公开(公告)日：2005-01-18
申请号：US09675430
申请日：2000-09-29
CPC分类号： H04R19/00 , Y10T29/49002 , Y10T29/49005 , Y10T29/4908
摘要： An electrostatic speaker is constructed using a thin flexible membrane as the active member. This membrane is uniformly positioned against at least one printed circuit board containing at least one stator fixed in the PCB. Variations in structure are provided, all including at least one PCB and a membrane. In a preferred embodiment, intermeshing opposing ridges on the PCBs are adjacent to a central vibrating area of the membrane, and serve to position and tension the membrane. Attachment means connect the PCBs together, and electrical connections permit the passage of current to bias the membrane and to drive the stators to vibrate the membrane, producing acoustical output in the sonic or ultrasonic ranges. The invention also relates to the electrostatic speakers produced by this method of manufacture.
摘要翻译： 使用薄柔性膜作为活性构件构造静电扬声器。 该膜相对于至少一个包含至少一个固定在PCB中的定子的印刷电路板均匀地定位。 提供了结构的变化，全部包括至少一个PCB和膜。 在一个优选实施例中，PCB上的相对的脊相互啮合邻近膜的中心振动区域，并且用于定位和张紧膜。 连接装置将PCB连接在一起，并且电气连接允许电流通过以偏置隔膜并驱动定子振动隔膜，在声波或超声波范围内产生声学输出。 本发明还涉及通过该制造方法制造的静电扬声器。
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公开(公告)号：USD390954S
公开(公告)日：1998-02-17
申请号：US52627
申请日：1996-03-28
申请人： G. Kris Kumar , David A. Mann
设计人： G. Kris Kumar , David A. Mann
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