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公开(公告)号:US20130108582A1
公开(公告)日:2013-05-02
申请号:US13475352
申请日:2012-05-18
申请人: Alfredo C. Castro , Michael J. Grogan , William Matsui , Karen J. McGovern , Martin R. Tremblay
发明人: Alfredo C. Castro , Michael J. Grogan , William Matsui , Karen J. McGovern , Martin R. Tremblay
IPC分类号: C07D491/107 , A61K31/56 , A61K38/21 , A61K31/704 , A61K31/573 , A61K31/196 , A61K31/519 , A61K31/4745 , A61K31/69 , A61K31/198 , A61K31/17 , A61K31/664 , A61K31/454 , A61K31/7068 , A61K31/7076 , A61K31/4355
CPC分类号: A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
摘要翻译: 本发明提供使用具有下式的环巴胺衍生物治疗各种病症的方法:
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公开(公告)号:US20120077834A1
公开(公告)日:2012-03-29
申请号:US13191545
申请日:2011-07-27
申请人: Alfredo C. Castro , Michael J. Grogan , William Matsui , Karen J. McGovern , Martin R. Tremblay
发明人: Alfredo C. Castro , Michael J. Grogan , William Matsui , Karen J. McGovern , Martin R. Tremblay
IPC分类号: A61K31/4355 , A61P35/02 , A61P35/00
CPC分类号: A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
摘要翻译: 本发明提供使用具有下式的环巴胺衍生物治疗各种病症的方法:
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公开(公告)号:US08227509B2
公开(公告)日:2012-07-24
申请号:US13191545
申请日:2011-07-27
申请人: Alfredo C. Castro , Michael J. Grogan , William Matsui , Karen J. McGovern , Martin R. Tremblay
发明人: Alfredo C. Castro , Michael J. Grogan , William Matsui , Karen J. McGovern , Martin R. Tremblay
IPC分类号: A61K315/35 , A61K31/27 , A61K31/54 , A61K31/56
CPC分类号: A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
摘要翻译: 本发明提供使用具有下式的环巴胺衍生物治疗各种病症的方法:
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公开(公告)号:US20110230509A1
公开(公告)日:2011-09-22
申请号:US13090694
申请日:2011-04-20
申请人: Alfredo C. Castro , Michael J. Grogan , William Matsui , Karen J. McGovern , Martin R. Tremblay
发明人: Alfredo C. Castro , Michael J. Grogan , William Matsui , Karen J. McGovern , Martin R. Tremblay
IPC分类号: A61K31/4355 , A61P35/00
CPC分类号: A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
摘要翻译: 本发明提供使用具有下式的环巴胺衍生物治疗各种病症的方法:
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公开(公告)号:US20130108583A1
公开(公告)日:2013-05-02
申请号:US13475510
申请日:2012-05-18
申请人: Alfredo C. Castro , Michael J. Grogan , William Matsui , Karen J. McGovern , Martin R. Tremblay
发明人: Alfredo C. Castro , Michael J. Grogan , William Matsui , Karen J. McGovern , Martin R. Tremblay
IPC分类号: C07D491/107 , A61K31/4355 , A61K45/06
CPC分类号: A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
摘要翻译: 本发明提供使用具有下式的环巴胺衍生物治疗各种病症的方法:
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公开(公告)号:US08895576B2
公开(公告)日:2014-11-25
申请号:US13475352
申请日:2012-05-18
IPC分类号: A61K31/44 , A61K31/56 , A61K31/4355 , A61K31/58 , A61K31/519 , A61K31/198 , A61K38/21 , A61K31/704 , A61K31/573 , A61K31/454 , A61K31/7068 , C07D491/04 , A61K31/7076 , C07D491/107 , C07D491/10 , A61K31/4745 , A61K31/17 , C07J69/00 , C07D491/048 , A61K45/06 , A61K31/69 , A61K31/664 , A61K31/196
CPC分类号: A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
摘要翻译: 本发明提供使用具有下式的环巴胺衍生物治疗各种病症的方法:
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公开(公告)号:US20100286180A1
公开(公告)日:2010-11-11
申请号:US11965675
申请日:2007-12-27
IPC分类号: A61K31/4355 , A61P35/00 , A61P35/04
CPC分类号: A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
摘要翻译: 本发明提供使用具有下式的环巴胺衍生物治疗各种病症的方法:
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公开(公告)号:US08017648B2
公开(公告)日:2011-09-13
申请号:US11965675
申请日:2007-12-27
CPC分类号: A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
摘要翻译: 本发明提供了使用具有下式的环巴胺衍生物治疗各种病症的方法:
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公开(公告)号:US20100222287A1
公开(公告)日:2010-09-02
申请号:US12567160
申请日:2009-09-25
申请人: Karen J. McGovern , Margaret Read , Robert W. Ross
发明人: Karen J. McGovern , Margaret Read , Robert W. Ross
IPC分类号: A61K31/7048 , A61K31/704 , A61K31/56 , A61K31/4355 , A61K31/475 , A61K31/337 , A61K31/282 , A61P35/00
CPC分类号: A61K31/00 , A61K31/282 , A61K31/337 , A61K31/4355 , A61K31/7068 , A61K33/24 , A61K45/06 , C07J69/00 , A61K2300/00
摘要: Provided are methods for treating prostate cancer by administering a therapeutically effective amount of a hedgehog inhibitor.
摘要翻译: 提供了通过施用治疗有效量的刺猬蛋白抑制剂来治疗前列腺癌的方法。
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10.METHODS AND COMPOSITIONS FOR IDENTIFICATION, ASSESSMENT AND TREATMENT OF CANCERS ASSOCIATED WITH HEDGEHOG SIGNALING 审中-公开
标题翻译: 用HEDGEHOG信号相关的癌症鉴定,评估和治疗方法和组合公开(公告)号:US20120010230A1
公开(公告)日:2012-01-12
申请号:US13179438
申请日:2011-07-08
申请人: John R. MacDougall , Juan Guillermo Paez , Karen J. McGovern , Jeffery L. Kutok , Georgios Skliris , Kerry White , Kerrie L. Faia , Marisa Osswalt Peluso , Veronica Travaglione Campbell
发明人: John R. MacDougall , Juan Guillermo Paez , Karen J. McGovern , Jeffery L. Kutok , Georgios Skliris , Kerry White , Kerrie L. Faia , Marisa Osswalt Peluso , Veronica Travaglione Campbell
IPC分类号: A61K31/4355 , A61P35/02 , G01N33/53 , C12Q1/02 , C12Q1/68 , C12Q1/37 , C12Q1/48 , A61P35/00 , C40B30/04
CPC分类号: G01N33/57484 , A61K31/4355 , A61K31/7068 , A61K38/38 , A61K39/39558 , A61K45/06 , A61N5/1001 , C07K16/22 , C12Q1/37 , C12Q1/48 , C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/5017 , G01N33/5041 , G01N33/574 , G01N2500/04 , G01N2800/50 , G01N2800/52 , G01N2800/56 , A61K2300/00
摘要: Provided herein are methods, assays and kits for evaluating a sample, e.g., a sample obtained from a cancer patient, to detect one or more hedgehog biomarkers and/or one or more cilium markers. Thus, the invention can be used, inter alia, as a means to identify patients likely to benefit from administration of one or more hedgehog inhibitors, alone or in combination with therapeutic agents; to predict a time course of disease or a probability of a significant event in the disease of a cancer patient; to stratify patient populations; and/or to more effectively treat or prevent a cancer or a tumor associated with hedgehog signaling.
摘要翻译: 本文提供了用于评估样品(例如从癌症患者获得的样品)检测一种或多种刺猬生物标志物和/或一种或多种纤毛标记物的方法,测定和试剂盒。 因此,本发明尤其可以用于鉴定单独或与治疗剂组合可能受益于一种或多种刺猬蛋白抑制剂的受益的患者的手段; 预测疾病的时间过程或癌症患者疾病中重大事件的概率; 分层患者人群; 和/或更有效地治疗或预防与刺猬蛋白信号传导相关的癌症或肿瘤。
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