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    METHODS AND SYSTEMS FOR DIGITALLY ENHANCING AN IMAGE OF A STAINED MATERIAL
    1.
    发明申请
    METHODS AND SYSTEMS FOR DIGITALLY ENHANCING AN IMAGE OF A STAINED MATERIAL 有权
    用于数字增强不均匀材料图像的方法和系统

    公开(公告)号：US20110026803A1

    公开(公告)日：2011-02-03

    申请号：US12533406

    申请日：2009-07-31

    申请人： Ali Can ,  Cemal Cagatay Bilgin ,  Jens Rittscher ,  Robert John Filkins

    发明人： Ali Can ,  Cemal Cagatay Bilgin ,  Jens Rittscher ,  Robert John Filkins

    IPC分类号： G06K9/00

    CPC分类号： G06T5/004 ,  G06T2207/10024 ,  G06T2207/30024

    摘要： Methods and systems for digitally enhancing an initial image of a material to which a plurality of stains were previously applied, that generally comprise: unmixing the image into a plurality of individual reconstructed images, each individual image corresponding to one of the stains; estimating a residual image corresponding to the difference between the original image and the reconstructed images; adjusting one or more components of the individual images; mixing the adjusted components using one or more estimated mixing coefficients; and adding the residual image to the mixed adjusted components to generate an enhanced image.

    摘要翻译： 用于数字增强先前施加多个污渍的材料的初始图像的方法和系统，其通常包括：将图像混合成多个单独的重建图像，每个单独图像对应于一个污渍; 估计对应于原始图像和重建图像之间的差的残差图像; 调整各个图像的一个或多个分量; 使用一个或多个估计的混合系数混合调整的组分; 并且将残差图像添加到混合调整的分量以产生增强图像。

    Methods and systems for digitally enhancing an image of a stained material
    2.
    发明授权
    Methods and systems for digitally enhancing an image of a stained material 有权
    用于数字增强染色材料图像的方法和系统

    公开(公告)号：US08948488B2

    公开(公告)日：2015-02-03

    申请号：US12533406

    申请日：2009-07-31

    申请人： Ali Can ,  Cemal Cagatay Bilgin ,  Jens Rittscher ,  Robert John Filkins

    发明人： Ali Can ,  Cemal Cagatay Bilgin ,  Jens Rittscher ,  Robert John Filkins

    IPC分类号： G06K9/00 ,  G06T5/00

    CPC分类号： G06T5/004 ,  G06T2207/10024 ,  G06T2207/30024

    摘要： Methods and systems for digitally enhancing an initial image of a material to which a plurality of stains were previously applied, that generally comprise: unmixing the image into a plurality of individual reconstructed images, each individual image corresponding to one of the stains; estimating a residual image corresponding to the difference between the original image and the reconstructed images; adjusting one or more components of the individual images; mixing the adjusted components using one or more estimated mixing coefficients; and adding the residual image to the mixed adjusted components to generate an enhanced image.

    摘要翻译： 用于数字增强先前施加多个污渍的材料的初始图像的方法和系统，其通常包括：将图像混合成多个单独的重建图像，每个单独的图像对应于一个污渍; 估计对应于原始图像和重建图像之间的差的残差图像; 调整各个图像的一个或多个分量; 使用一个或多个估计的混合系数混合调整的组分; 并将残差图像添加到混合调整的分量以产生增强图像。

    SYSTEM AND METHOD FOR THE QUANTITATIVE ASSESSMENT OF DIGITAL HISTOLOGY IMAGES
    3.
    发明申请
    SYSTEM AND METHOD FOR THE QUANTITATIVE ASSESSMENT OF DIGITAL HISTOLOGY IMAGES 审中-公开
    数字化学图像定量评估系统与方法

    公开(公告)号：US20110075914A1

    公开(公告)日：2011-03-31

    申请号：US12571158

    申请日：2009-09-30

    申请人： Robert John Filkins ,  Kevin Kenny ,  David Henderson ,  Jens Rittscher

    发明人： Robert John Filkins ,  Kevin Kenny ,  David Henderson ,  Jens Rittscher

    IPC分类号： G06K9/00

    CPC分类号： G06K9/00127 ,  G06K9/036 ,  G06T7/0002 ,  G06T7/41 ,  G06T2200/32 ,  G06T2207/10056 ,  G06T2207/30024

    摘要： The present disclosure concerns a method and system for assessing image quality of sub-images used to form a composite image using an algorithm developed by applying statistical correlation techniques to historical data on features of sub-images which were manually evaluated by experts and using those assessment to make decisions about the further processing of the sub-images which are being assessed. The method and system find particular value in the processing of sub-images generated while there is relative motion between the specimen under examination and the objective lens of a microscope such as when the microscope stage follows a planned traverse in the focal plane and a digital image is created at intervals correlated to the motion of the stage so that a region of interest in the specimen under examination is covered by the sub-images. The further processing decisions include manually examining the sub-images assessed to have unacceptable image quality, reimaging the entire region of interest and recreating specific sub-images. The method and system may also involve overlaying portions of a composite image with an indication that they were drawn from sub-images of unacceptable image quality.

    摘要翻译： 本公开涉及一种用于评估用于形成合成图像的子图像的图像质量的方法和系统，该方法和系统使用通过将统计相关技术应用于由专家手动评估的子图像的特征的历史数据而开发的算法，并使用这些评估 做出关于正在评估的子图像的进一步处理的决定。 该方法和系统在检查中的样本与显微镜的物镜之间产生的子图像的处理中发现特定的值，例如当显微镜载物台在焦平面上进行计划的横越时，以及数字图像 以与舞台的运动相关的间隔创建，使得被检查的样本中的感兴趣区域被子图像覆盖。 进一步的处理决定包括手动检查评估为具有不可接受的图像质量的子图像，重新映像整个感兴趣区域并重新创建特定子图像。 该方法和系统还可以包括将合成图像的部分重叠，并显示它们是从不可接受的图像质量的子图像中提取的。

    Sequential analysis of biological samples
    4.
    发明授权
    Sequential analysis of biological samples 有权
    生物样品的顺序分析

    公开(公告)号：US07741045B2

    公开(公告)日：2010-06-22

    申请号：US11864085

    申请日：2007-09-28

    申请人： Michael J. Gerdes ,  Anup Sood ,  Michael Christopher Montalto ,  Ali Can ,  Fiona Ginty ,  Maureen Ann Bresnahan ,  Robert John Filkins ,  Zhengyu Pang

    发明人： Michael J. Gerdes ,  Anup Sood ,  Michael Christopher Montalto ,  Ali Can ,  Fiona Ginty ,  Maureen Ann Bresnahan ,  Robert John Filkins ,  Zhengyu Pang

    IPC分类号： C12Q1/68 ,  G01N33/53

    CPC分类号： G01N33/582 ,  C12Q1/6816 ,  G01N33/542 ,  C12Q2545/101 ,  C12Q2527/125

    摘要： Methods for probing multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets, binding at least one fluorescent probe to one or more target present in the sample, and binding at least at least one control probe to one or more target present in the sample. The methods include the steps of observing a signal from the fluorescent probe and a control signal from the control probe and applying to the sample a basic solution containing an oxidizing agent that selectively inactivates the fluorescent probe and not the control probe. The methods further include the steps of binding at least one fluorescent probe to one or more target present in the sample and observing a signal from the fluorescent probe. The methods disclosed herein also provide for multiple iterations of binding, observing, and oxidizing for deriving information about multiple targets in a single sample. An associated kit is also provided.

    摘要翻译： 提供了探测生物样品中多个靶标的方法。 所述方法包括以下步骤：提供含有多个靶标的生物样品，将至少一种荧光探针结合至样品中存在的一种或多种靶标，以及将至少一种对照探针结合至样品中存在的一种或多种靶标。 所述方法包括以下步骤：观察来自荧光探针的信号和来自对照探针的控制信号，并向样品施加含有选择性灭活荧光探针而不是对照探针的氧化剂的碱性溶液。 所述方法还包括将至少一种荧光探针结合到样品中存在的一种或多种目标物并观察来自荧光探针的信号的步骤。 本文公开的方法还提供结合，观察和氧化的多次迭代，用于导出关于单个样本中的多个目标的信息。 还提供了相关的套件。

    SEQUENTIAL ANALYSIS OF BIOLOGICAL SAMPLES
    5.
    发明申请
    SEQUENTIAL ANALYSIS OF BIOLOGICAL SAMPLES 有权
    生物样品的序列分析

    公开(公告)号：US20080118934A1

    公开(公告)日：2008-05-22

    申请号：US11864085

    申请日：2007-09-28

    申请人： Michael J. Gerdes ,  Anup Sood ,  Michael Christopher Montalto ,  Ali Can ,  Fiona Ginty ,  Maureen Ann Bresnahan ,  Robert John Filkins ,  Zhengyu Pang

    发明人： Michael J. Gerdes ,  Anup Sood ,  Michael Christopher Montalto ,  Ali Can ,  Fiona Ginty ,  Maureen Ann Bresnahan ,  Robert John Filkins ,  Zhengyu Pang

    IPC分类号： G01N33/53 ,  G01N33/566 ,  G01N33/567

    CPC分类号： G01N33/582 ,  C12Q1/6816 ,  G01N33/542 ,  C12Q2545/101 ,  C12Q2527/125

    摘要： Methods for probing multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets, binding at least one fluorescent probe to one or more target present in the sample, and binding at least at least one control probe to one or more target present in the sample. The methods include the steps of observing a signal from the fluorescent probe and a control signal from the control probe and applying to the sample a basic solution containing an oxidizing agent that selectively inactivates the fluorescent probe and not the control probe. The methods further include the steps of binding at least one fluorescent probe to one or more target present in the sample and observing a signal from the fluorescent probe. The methods disclosed herein also provide for multiple iterations of binding, observing, and oxidizing for deriving information about multiple targets in a single sample. An associated kit is also provided.

    摘要翻译： 提供了探测生物样品中多个靶标的方法。 所述方法包括以下步骤：提供含有多个靶标的生物样品，将至少一种荧光探针结合至样品中存在的一种或多种靶标，以及将至少一种对照探针结合至样品中存在的一种或多种靶标。 所述方法包括以下步骤：观察来自荧光探针的信号和来自对照探针的控制信号，并向样品施加含有选择性灭活荧光探针而不是对照探针的氧化剂的碱性溶液。 所述方法还包括将至少一种荧光探针结合到样品中存在的一种或多种目标物并观察来自荧光探针的信号的步骤。 本文公开的方法还提供结合，观察和氧化的多次迭代，用于导出关于单个样本中的多个目标的信息。 还提供了相关的套件。

    SEQUENTIAL ANALYSIS OF BIOLOGICAL SAMPLES
    9.
    发明申请
    SEQUENTIAL ANALYSIS OF BIOLOGICAL SAMPLES 有权
    生物样品的序列分析

    公开(公告)号：US20120231967A1

    公开(公告)日：2012-09-13

    申请号：US13457531

    申请日：2012-04-27

    申请人： Anup Sood ,  Michael Christopher Montalto ,  Michael Gerdes ,  Maximilian Lewis Seel ,  Robert John Filkins

    发明人： Anup Sood ,  Michael Christopher Montalto ,  Michael Gerdes ,  Maximilian Lewis Seel ,  Robert John Filkins

    IPC分类号： C40B30/04

    CPC分类号： G01N33/53 ,  C12Q1/68 ,  G01N33/542 ,  G01N33/582 ,  Y10T436/143333

    摘要： Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.

    摘要翻译： 提供了用于检测生物样品中多个靶的方法。 所述方法包括使样品与第一探针接触; 将第一探针物理地绑定到第一靶; 观察来自第一探针的第一信号; 施用化学试剂来修饰第一信号; 使样品与第二探针接触; 将第二探针物理地绑定到第二靶上; 并观察来自第二探测器的第二信号。 本文公开的方法还提供绑定，观察，信号修改的多次迭代，用于导出关于单个样本中的多个目标的信息。 还提供了相关的套件和设备。