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公开(公告)号：US10251882B2
公开(公告)日：2019-04-09
申请号：US15141387
申请日：2016-04-28
IPC分类号： A61K31/5025 , C07D487/04 , A61K31/13 , A61K31/196 , A61K31/215 , A61K31/351 , A61K31/4965 , A61K31/5377 , A61K31/7056 , A61K38/21 , C07B59/00
摘要： Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection, with an aza-pyridone compounds. Examples of an orthomyxovirus viral infection include an influenza infection.
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公开(公告)号：US20180155384A1
公开(公告)日：2018-06-07
申请号：US15884052
申请日：2018-01-30
摘要： Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Picornavirus infection with one or more nucleosides, nucleotides and nucleotide analogs.
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公开(公告)号：US09932363B2
公开(公告)日：2018-04-03
申请号：US15215434
申请日：2016-07-20
IPC分类号： A01N43/04 , A61K31/70 , C07H19/06 , C07H19/20 , C07H19/16 , C07H19/10 , A61K31/7072 , A61K31/7068 , A61K31/708 , A61K45/06 , A61K31/7076
CPC分类号： C07H19/06 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K45/06 , C07H19/10 , C07H19/16 , C07H19/20 , A61K2300/00
摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection, with a nucleoside, a nucleotide and an analog thereof.
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公开(公告)号：US09862743B2
公开(公告)日：2018-01-09
申请号：US14510451
申请日：2014-10-09
发明人： Leonid Beigelman , Guangyi Wang , David Bernard Smith , Marija Prhavc , Christian Andreas Jekle , Jerome Deval
IPC分类号： A61K31/7052 , A61K31/7064 , A61K31/7072 , A61K31/7076 , A61K31/708 , C07H19/20 , C07H19/06 , C07H19/16 , C07H19/10 , C07H19/11 , C07H19/207 , C07H19/213
CPC分类号： C07H19/20 , A61K31/7052 , A61K31/7064 , A61K31/7072 , A61K31/7076 , A61K31/708 , C07H19/06 , C07H19/10 , C07H19/11 , C07H19/16 , C07H19/207 , C07H19/213
摘要： Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Picornavirus and/or Flaviviridae infection with one or more nucleosides, nucleotides and nucleotide analogs.
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公开(公告)号：US20170143751A1
公开(公告)日：2017-05-25
申请号：US15427964
申请日：2017-02-08
发明人： Lawrence M. Blatt , Leonid Beigelman , Natalia Dyatkina , Julian Alexander Symons , David Bernard Smith
IPC分类号： A61K31/7068 , A61K31/708 , A61K31/7076 , A61K31/7072
CPC分类号： A61K31/7068 , A61K31/7052 , A61K31/706 , A61K31/7064 , A61K31/7072 , A61K31/7076 , A61K31/708
摘要： Disclosed herein are nucleosides, nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Filoviridae virus infection with one or more nucleosides and/or nucleotide analogs.
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公开(公告)号：US20170143749A1
公开(公告)日：2017-05-25
申请号：US15423270
申请日：2017-02-02
IPC分类号： A61K31/708 , A61K31/7072 , A61K31/7076 , A61K31/7068
CPC分类号： A61K31/708 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K45/06 , C07F9/65586 , C07F9/65742
摘要： Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Coronaviridae virus, a Togaviridae virus, a Hepeviridae virus and/or a Bunyaviridae virus infection with one or more nucleosides, nucleotides and nucleotide analogs.
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公开(公告)号：US09605018B2
公开(公告)日：2017-03-28
申请号：US14608523
申请日：2015-01-29
发明人： Guangyi Wang , Leonid Beigelman
IPC分类号： A61K31/70 , C07H19/04 , A01N43/04 , C07H19/10 , C07H19/20 , A61K31/7056 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K38/21 , A61K45/06 , C07H19/207 , A61K31/381 , A61K31/497
CPC分类号： C07H19/20 , A61K31/381 , A61K31/497 , A61K31/7056 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K38/21 , A61K45/06 , C07H19/10 , C07H19/207
摘要： Disclosed herein are phosphorothioate nucleotide analogs, methods of synthesizing phosphorothioate nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with the phosphorothioate nucleotide analogs.
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公开(公告)号：US20160318967A1
公开(公告)日：2016-11-03
申请号：US15215434
申请日：2016-07-20
IPC分类号： C07H19/06 , A61K31/7072 , A61K31/7068 , C07H19/20 , C07H19/16 , A61K31/708 , A61K31/7076 , A61K45/06 , C07H19/10
CPC分类号： C07H19/06 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K45/06 , C07H19/10 , C07H19/16 , C07H19/20 , A61K2300/00
摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection, with a nucleoside, a nucleotide and an analog thereof.
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公开(公告)号：US09365605B2
公开(公告)日：2016-06-14
申请号：US14312179
申请日：2014-06-23
IPC分类号： C07H17/02 , A61K31/14 , A61K31/513 , A61K31/52 , A61K45/06 , C07H19/11 , C07H19/213
CPC分类号： C07H19/20 , A61K31/14 , A61K31/513 , A61K31/52 , A61K31/685 , A61K31/7072 , A61K31/7076 , A61K45/06 , C07F9/65744 , C07H17/02 , C07H19/10 , C07H19/11 , C07H19/213 , Y02A50/414 , Y02A50/465 , A61K2300/00
摘要： Disclosed herein are cyclic nucleotide analogs, methods of synthesizing cyclic nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with cyclic nucleotide analogs.
摘要翻译： 本文公开了环状核苷酸类似物，合成环状核苷酸类似物的方法和用环状核苷酸类似物治疗疾病和/或病症如病毒感染，癌症和/或寄生虫病的方法。
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公开(公告)号：US20160115190A1
公开(公告)日：2016-04-28
申请号：US14923283
申请日：2015-10-26
IPC分类号： C07H19/06
摘要： Disclosed herein are methods of preparing a nucleoside analog, which are useful in treating diseases and/or conditions such as viral infections, and intermediates thereof.
摘要翻译： 本文公开了制备核苷类似物的方法，其可用于治疗疾病和/或病症如病毒感染及其中间体。
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