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公开(公告)号:US09447177B2
公开(公告)日:2016-09-20
申请号:US13416684
申请日:2012-03-09
申请人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Glenn Friedrich
发明人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Glenn Friedrich
IPC分类号: A01K67/027 , C07K16/00 , C12N15/85 , C07K16/18 , C07K16/12 , C07K16/46 , A61K39/02 , A61K39/35
CPC分类号: A01K67/0278 , A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K2207/15 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/01 , A61K39/107 , A61K39/35 , A61K2039/505 , C07K16/00 , C07K16/1203 , C07K16/1239 , C07K16/18 , C07K16/462 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C12N15/8509 , C12N2015/8518
摘要: The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanized antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
摘要翻译: 本发明公开了产生嵌合人非 - 人抗体和嵌合抗体链,如此制备的抗体和抗体链的方法及其衍生物,包括完全人源化抗体; 包含适合用于所述方法的所述抗体,抗体链和衍生物的组合物,以及细胞,非人哺乳动物和载体。
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公开(公告)号:US09290566B2
公开(公告)日:2016-03-22
申请号:US13416684
申请日:2012-03-09
申请人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Glenn Friedrich
发明人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Glenn Friedrich
摘要: The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanized antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
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公开(公告)号:US09253965B2
公开(公告)日:2016-02-09
申请号:US13434361
申请日:2012-03-29
申请人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Dominik Spensberger , Hui Liu , Jasper Clube
发明人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Dominik Spensberger , Hui Liu , Jasper Clube
IPC分类号: A01K67/027 , C12N5/06 , C12N15/87 , C07H21/04 , C12N15/85 , C07K16/12 , C07K16/18 , C07K16/46
CPC分类号: C07K16/461 , A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07H21/04 , C07K16/1239 , C07K16/18 , C07K16/462 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/35 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/63 , C12N15/8509 , C12N2015/8518 , C12N2800/30 , C12N2800/80
摘要: The invention discloses methods for the generation of chimaeric human-nonhuman antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising the disclosed antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in the disclosed methods.
摘要翻译: 本发明公开了产生嵌合人非人抗体和嵌合抗体链,如此产生的抗体和抗体链的方法及其衍生物,包括完全人源化抗体; 包含公开的抗体,抗体链和衍生物的组合物,以及适用于所公开的方法的细胞,非人哺乳动物和载体。
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公开(公告)号:US20120167237A1
公开(公告)日:2012-06-28
申请号:US13416684
申请日:2012-03-09
申请人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Anais Legent , Ian Kirby
发明人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Anais Legent , Ian Kirby
IPC分类号: A01K67/027 , C12N5/10 , C12N15/85 , C12N15/13 , C07K16/00
CPC分类号: A01K67/0278 , A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K2207/15 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/01 , A61K39/107 , A61K39/35 , A61K2039/505 , C07K16/00 , C07K16/1203 , C07K16/1239 , C07K16/18 , C07K16/462 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C12N15/8509 , C12N2015/8518
摘要: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
摘要翻译: 本发明公开了产生嵌合人非 - 人抗体和嵌合抗体链,如此产生的抗体和抗体链的方法及其衍生物,包括完全人源化抗体; 包含适合用于所述方法的所述抗体,抗体链和衍生物的组合物,以及细胞,非人哺乳动物和载体。
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公开(公告)号:US20130263293A1
公开(公告)日:2013-10-03
申请号:US13433084
申请日:2012-03-28
申请人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Dominik Spensberger , Hui Liu , Jasper Clube
发明人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Dominik Spensberger , Hui Liu , Jasper Clube
IPC分类号: C07K16/46 , C12N15/85 , A01K67/027
CPC分类号: C07K16/462 , A01K67/0278 , A01K2217/052 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/1239 , C07K16/1282 , C07K16/18 , C07K16/46 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/56 , C07K2317/92 , C12N15/85 , C12N15/8509 , C12N2015/8518
摘要: The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
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公开(公告)号:US09445581B2
公开(公告)日:2016-09-20
申请号:US13433084
申请日:2012-03-28
申请人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Dominik Spensberger , Hui Liu , Jasper Clube
发明人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Dominik Spensberger , Hui Liu , Jasper Clube
IPC分类号: C12P21/00 , A01K67/027 , C12N5/06 , C12P21/08 , C07K16/46 , C12N15/85 , C07K16/12 , C07K16/18 , C07K16/00
CPC分类号: C07K16/462 , A01K67/0278 , A01K2217/052 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/1239 , C07K16/1282 , C07K16/18 , C07K16/46 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/56 , C07K2317/92 , C12N15/85 , C12N15/8509 , C12N2015/8518
摘要: The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanized antibodies; compositions comprising the disclosed antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in the disclosed methods.
摘要翻译: 本发明公开了产生嵌合人非 - 人抗体和嵌合抗体链,如此制备的抗体和抗体链的方法及其衍生物,包括完全人源化抗体; 包含所公开的抗体,抗体链和衍生物的组合物,以及适用于所公开的方法的细胞,非人哺乳动物和载体。
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公开(公告)号:US20130263292A1
公开(公告)日:2013-10-03
申请号:US13434361
申请日:2012-03-29
申请人: Qi Liang , Allan Bradley , E-Chiang Lee , Wei Wang , Dominik Spensberger , Hui Liu , Jasper Clube
发明人: Qi Liang , Allan Bradley , E-Chiang Lee , Wei Wang , Dominik Spensberger , Hui Liu , Jasper Clube
IPC分类号: A01K67/027 , C12N15/85 , C12N5/10
CPC分类号: C07K16/461 , A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07H21/04 , C07K16/1239 , C07K16/18 , C07K16/462 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/35 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/63 , C12N15/8509 , C12N2015/8518 , C12N2800/30 , C12N2800/80
摘要: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
摘要翻译: 本发明公开了产生嵌合人非 - 人抗体和嵌合抗体链,如此产生的抗体和抗体链的方法及其衍生物,包括完全人源化抗体; 包含适合用于所述方法的所述抗体,抗体链和衍生物的组合物,以及细胞,非人哺乳动物和载体。
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公开(公告)号:US20130042331A2
公开(公告)日:2013-02-14
申请号:US13416684
申请日:2012-03-09
申请人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Anais Legent , Ian Kirby
发明人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Anais Legent , Ian Kirby
IPC分类号: A01K67/027 , C12N5/10 , C12N15/85 , C12N15/13 , C07K16/00
CPC分类号: A01K67/0278 , A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K2207/15 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/01 , A61K39/107 , A61K39/35 , A61K2039/505 , C07K16/00 , C07K16/1203 , C07K16/1239 , C07K16/18 , C07K16/462 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C12N15/8509 , C12N2015/8518
摘要: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
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公开(公告)号:US20120204278A1
公开(公告)日:2012-08-09
申请号:US13310431
申请日:2011-12-02
申请人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Anais Legent , Ian Kirby
发明人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Anais Legent , Ian Kirby
IPC分类号: A01K67/027 , C07H21/04 , C07K16/00 , C12N15/63 , C12N5/10
CPC分类号: A01K67/0278 , A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K2207/15 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/01 , A61K39/107 , A61K39/35 , A61K2039/505 , C07K16/00 , C07K16/1203 , C07K16/1239 , C07K16/18 , C07K16/462 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C12N15/8509 , C12N2015/8518
摘要: The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
摘要翻译: 本发明公开了产生嵌合人非 - 人抗体和嵌合抗体链,如此产生的抗体和抗体链的方法及其衍生物,包括完全人源化抗体; 包含适合用于所述方法的所述抗体,抗体链和衍生物的组合物,以及细胞,非人哺乳动物和载体。
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10.
公开(公告)号:US6136566A
公开(公告)日:2000-10-24
申请号:US726867
申请日:1996-10-04
申请人: Arthur Sands , Glenn Friedrich , Brian Zambrowicz , Allan Bradley
发明人: Arthur Sands , Glenn Friedrich , Brian Zambrowicz , Allan Bradley
CPC分类号: C12N15/86 , C12N15/102 , C12N15/1034 , C12N15/85 , A01K2217/075 , C12N2740/10043 , C12N2800/60 , C12N2840/44
摘要: Methods and vectors (both DNA and retroviral) are provided for the construction of a Library of mutated cells. The Library will preferably contain mutations in essentially all genes present in the genome of the cells. The nature of the Library and the vectors allow for methods of screening for mutations in specific genes, and for gathering nucleotide sequence data from each mutated gene to provide a database of tagged gene sequences. Such a database provides a means to access the individual mutant cell clones contained in the Library. The invention includes the described Library, methods of making the same, and vectors used to construct the Library. Methods are also provided for accessing individual parts of the Library either by sequence or by pooling and screening. The invention also provides for the generation of non-human transgenic animals which are mutant for specific genes as isolated and generated from the cells of the Library.
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