公开(公告)号：US06664305B2

公开(公告)日：2003-12-16

申请号：US10182768

申请日：2002-10-28

申请人： Alois Jungbauer ,  Rainer Hahn ,  Ales Podgornik ,  Milos Barut ,  Ales Strancar

发明人： Alois Jungbauer ,  Rainer Hahn ,  Ales Podgornik ,  Milos Barut ,  Ales Strancar

IPC分类号： C08J928

CPC分类号： G01N30/482 ,  B01D15/361 ,  B01D15/3804 ,  B01D15/3809 ,  B01J20/26 ,  B01J20/28042 ,  B01J20/285 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/327 ,  B01J20/3272 ,  B01J20/3282 ,  B01J2220/54 ,  B01J2220/82

摘要： A process of manufacturing of a chromatography material comprising the steps of (i) reacting a polymerizable at least bifunctional monomer A with a ligand also having a functional group which binds covalently with one of the functional groups of said polymerizable bifunctional monomer A, (ii) to form a compound B comprising at least one polymerizable functional moiety (iii) polymerizing the compound B essentially alone or with the polymerizable monomers in presence of porogenes to obtain a block of porous polymerizate which is self-supporting or (iv) reacting the ligand and a spacer via a covalent bond which is cleavable to form a ligand-spacer conjugate and binding the ligand-spacer conjugate to the surface of a chromatographic support or reacting the ligand-spacer conjugate via a covalent bond to the at least bi-functional monomer A and polymerizing it essentially alone or with the polymerizable monomers in presence of porogenes to obtain a block of porous polymerizate which is self-supporting.

摘要翻译： 一种制备色谱材料的方法，包括以下步骤：（i）使可聚合的至少双官能单体A与还具有与所述可聚合双官能单体A的一个官能团共价键合的官能团的配体反应，（ii） 以形成包含至少一个可聚合官能部分的化合物B（iii）在致孔剂存在下基本上单独或与可聚合单体聚合化合物B以获得自支撑的多孔聚合物嵌段，或（iv）使配体和 通过共价键的间隔物，其可切割以形成配体 - 间隔基缀合物并将配体 - 间隔物缀合物结合到色谱载体的表面或通过共价键与配体 - 间隔物缀合物反应至至少双官能单体A 并在致孔剂存在下基本上单独或与可聚合单体聚合，得到多孔聚合物嵌段，其为自支撑 锻炼。

公开(公告)号：US06736973B1

公开(公告)日：2004-05-18

申请号：US09601037

申请日：2000-07-26

申请人： Ales Podgornik ,  Milos Barut ,  Ales Strancar ,  Djuro Josic

发明人： Ales Podgornik ,  Milos Barut ,  Ales Strancar ,  Djuro Josic

IPC分类号： B01D1508

CPC分类号： G01N30/482 ,  B01D15/325 ,  B01D15/327 ,  B01D15/363 ,  B01J20/261 ,  B01J20/28042 ,  B01J20/28092 ,  B01J20/28097 ,  B01J20/285 ,  B01J20/287 ,  B01J2220/54 ,  B01J2220/82 ,  G01N30/56 ,  G01N30/6004 ,  G01N30/6069 ,  G01N30/6091 ,  G01N2030/525 ,  G01N2030/528

摘要： A porous self-supporting structure comprising at least two porous components A and B and the porous component B embraces the porous component A, wherein (i) surfaces of pores of the at least two porous components A and B are provided with chemical moieties for interaction with substances passing the pores and (ii) the pores of the porous components comprise a uniform multimodal pore size distribution through the entire polymeric structure.

摘要翻译： 包含至少两个多孔组分A和B以及多孔组分B的多孔自支撑结构包括多孔组分A，其中（i）至少两个多孔组分A和B的孔表面设置有用于相互作用的化学部分 通过孔的物质和（ii）多孔组分的孔包含通过整个聚合物结构的均匀的多峰孔径分布。