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1.发明授权Method for improving the elicitation of IgG class monoclonal antibodies to tumor-associated antigens and glycoproteins 失效用于改善针对肿瘤相关抗原和糖蛋白的IgG类单克隆抗体的引发的方法
公开(公告)号：US4822734A
公开(公告)日：1989-04-18
申请号：US773340
申请日：1985-09-06
CPC分类号： C07K16/30 , A61K39/0011 , Y10S530/861 , Y10S530/864
摘要： Methods are disclosed for improving the efficiency of elicitation of monoclonal antibodies to glycoprotein antigens and tumor-associated antigens, and for inducing the production of IgG class monoclonal antibodies, in particular the IgG.sub.3 subclass. The methods involve the use of a lectin/extract immunogen to stimulate the production of the desired monoclonal antibodies.
摘要翻译： 公开了用于提高对糖蛋白抗原和肿瘤相关抗原的单克隆抗体的引发效率以及诱导产生IgG类单克隆抗体，特别是IgG3亚类的方法。 该方法涉及使用凝集素/提取物免疫原来刺激所需单克隆抗体的产生。
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2.发明授权
公开(公告)号：US4879225A
公开(公告)日：1989-11-07
申请号：US24632
申请日：1987-03-11
IPC分类号： G01N33/531 , A61K39/385 , A61K39/395 , A61K39/44 , C07K14/005 , C07K14/195 , C07K14/435 , C07K16/00 , C07K16/42 , C07K17/10 , C07K19/00 , C12N15/00 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/577
CPC分类号： C07K16/4266 , A61K39/385 , A61K39/44 , A61K2039/6056 , A61K2039/622 , C07K2317/32
摘要： A method for enhancing production of antibodies through immunization with insolubilized immune complexes is disclosed. Purified antigen or heterogeneous antigen mixtures may be combined with polyclonal or monoclonal antibody and the resultant complex bound to insolubilized protein A to form insolubilized immune complexes. Methods for improving the immunogenicity of a soluble antigen and for producing monoclonal anti-idiotypic antibodies are also disclosed. Monoclonal antibodies that are specific for a distinct, as yet unrecognized epitope may be produced by another disclosed method. Insolubilized immune complexes, comprising antigen and antibody that is either directly linked to Sepharose.RTM. or absorbed onto insolubolized protein A, and immunosorbents, comprising antibody absorbed onto insolubilized protein A, are also disclosed.
摘要翻译： 公开了通过用不溶性免疫复合物进行免疫来增强抗体产生的方法。 纯化的抗原或异源抗原混合物可以与多克隆或单克隆抗体组合，并且所得复合物与不溶蛋白A结合以形成不溶性免疫复合物。 还公开了用于改善可溶性抗原的免疫原性和用于产生单克隆抗独特型抗体的方法。 对于不同的尚未识别的表位特异的单克隆抗体可以通过另一公开的方法产生。 还公开了包含与Sepharose TM直接连接或被吸收到非溶解蛋白A上的抗原和抗体的免溶质免疫复合物，以及包含吸收在不溶蛋白A上的抗体的免疫吸附剂。
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3.发明授权
公开(公告)号：US5084396A
公开(公告)日：1992-01-28
申请号：US579627
申请日：1990-09-07
IPC分类号： A61K39/385 , A61K39/44 , C07K16/42 , C12P21/08
CPC分类号： C07K16/4266 , A61K39/385 , A61K39/44 , A61K2039/6056 , A61K2039/622 , C07K2317/32 , Y10S424/807 , Y10S530/861 , Y10S530/864
摘要： A method for enhancing production of antibodies through immunization with insolubilized immune complexes is disclosed. Purified antigen or heterogeneous antigen mixtures may be combined with polyclonal or monoclonal antibody and the resultant complex bound to an insolubilized matrix to form insolubilized immune complexes. Methods for improving the immunogenicity of a soluble antigen and for producing monoclonal anti-iodiotypic antibodies are also disclosed. Monoclonal antibodies that are specific for a distinct, as yet unrecognized epitope may be produced by another disclosed method . Insolubilized immune complexes, comprising antigen and antibody that is ether directly linked to Sepharose.RTM. or absorbed onto insolubilized protein A, and immunosorbents, comprising antibody absorbed onto insolubilized protein A, are also disclosed.
摘要翻译： 公开了通过用不溶性免疫复合物进行免疫来增强抗体产生的方法。 纯化的抗原或异源抗原混合物可以与多克隆或单克隆抗体组合，并且所得复合物与不溶性基质结合以形成不溶性免疫复合物。 还公开了用于改善可溶性抗原的免疫原性和用于产生单克隆抗碘代抗体的方法。 对于不同的尚未识别的表位特异的单克隆抗体可以通过另一公开的方法产生。 还公开了包含与Sepharose TM直接连接或被吸收到不溶蛋白A上的醚的抗原和抗体的免溶质免疫复合物，以及包含吸收在不溶蛋白A上的抗体的免疫吸附剂。
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