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![3-thioxo-[1,2,4]-oxadiazinan-5-one derivatives](/abs-image/US/2002/05/23/US20020061883A1/abs.jpg.150x150.jpg)
公开(公告)号：US20020061883A1
公开(公告)日：2002-05-23
申请号：US09965874
申请日：2001-09-28
IPC分类号： A61K031/5395 , C07D273/04
CPC分类号： C07D273/04
摘要： 1 wherein R is alkyl, alkenyl, or alkynyl; R1 and R2 are each independently hydrogen alkyl, or aryl; and Ar is phenyl, indanyl, benzhydryl, or phenyl, substituted with one or more groups selected from the group consisting of halogen, alkyl, perfluoroalkyl, lower alkoxy, perfluoroalkylalkoxy, dialkylamino, and aroyloxy.
摘要翻译： 其中R是烷基，烯基或炔基; R 1和R 2各自独立地为烷基或芳基; 并且Ar是被一个或多个选自卤素，烷基，全氟烷基，低级烷氧基，全氟烷基烷氧基，二烷基氨基和芳酰氧基的基团取代的苯基，茚满基，二苯甲基或苯基
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2.发明申请Imidazo-isoquinolin-5-one derivatives, pyrimido-isoquinolin-6-one derivatives and imidazo-naphthyridin-5-one derivatives 失效咪唑并 - 异喹啉-5-酮衍生物，嘧啶并 - 异喹啉-6-酮衍生物和咪唑并 - 萘啶-5-酮衍生物公开(公告)号：US20020061900A1
公开(公告)日：2002-05-23
申请号：US09965957
申请日：2001-09-28
IPC分类号： A61K031/519 , A61K031/4745
CPC分类号： A61K41/0057
摘要： Antiatherosclerotic compounds are provided which have the following structure: 1 wherein: R is hydrogen, lower alkyl, alkenyl, alkynyl, aryl, heteroaryl, or aryl or heteroaryl substituted with one or more members of the group consisting of alkyl, hydroxy, alkoxy, perfluoroalkyl, perfluoroalkoxy, alkylthio, nitro, amino, mono or di-alkylamino, and halogen; D is CnullH, carbon bound to R5 or nitrogen; R1, R2, R3, and R4 are each independently hydrogen, alkyl, or taken together form a ring; R5 is one or more groups selected from hydrogen, alkyl, alkenyl, alkynyl, aryl, hydroxy, alkoxy, perfluoroalkyl, perfluoroalkoxy, alkylthio, nitro, amino, mono or di-alkylamino, or halogen; n is an integer of 0-3; or pharmaceutically acceptable salts thereof.
摘要翻译： 提供具有以下结构的抗动脉粥样硬化化合物：其中：R是氢，低级烷基，烯基，炔基，芳基，杂芳基或被一个或多个由烷基，羟基，烷氧基，全氟烷基， 全氟烷氧基，烷硫基，硝基，氨基，一或二烷基氨基和卤素; D是C-H，与R 5或氮键合的碳; R 1，R 2，R 3和R 4各自独立地为氢，烷基或一起形成环; R5是选自氢，烷基，烯基，炔基，芳基，羟基，烷氧基，全氟烷基，全氟烷氧基，烷硫基，硝基，氨基，单或二 - 烷基氨基或卤素中的一个或多个基团。 n为0-3的整数; 或其药学上可接受的盐。
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公开(公告)号：US20020045776A1
公开(公告)日：2002-04-18
申请号：US09965898
申请日：2001-09-28
IPC分类号： C07C335/18
CPC分类号： C07C335/40 , C07C2602/08
摘要： Antiatherosclerotic compounds are provided which have the following structure: 1 wherein R is lower alkyl; R1 is hydroxy, amino, or lower alkoxy, R2 and R3 are each independently hydrogen, alkyl or aryl; Ar is phenyl, indanyl, benzhydryl, or phenyl substituted with one or more member selected from the group consisting of halogen, lower alkyl, perfluoroalkyl, lower alkoxy, perfluoroalkylalkoxy, dialkylamino, and aryloxy; or pharmaceutically acceptable salts thereof.
摘要翻译： 提供具有以下结构的抗动脉粥样硬化化合物：其中R是低级烷基; R1是羟基，氨基或低级烷氧基，R2和R3各自独立地是氢，烷基或芳基; Ar是苯基，茚满基，二苯甲基或被一个或多个选自卤素，低级烷基，全氟烷基，低级烷氧基，全氟烷基烷氧基，二烷基氨基和芳氧基的成员取代的苯基; 或其药学上可接受的盐。
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