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    Apparatus and methods for protecting against embolization during endovascular heart valve replacement
    1.
    发明申请
    Apparatus and methods for protecting against embolization during endovascular heart valve replacement 审中-公开
    血管内心脏瓣膜置换术中防止栓塞的装置和方法

    公开(公告)号：US20050137696A1

    公开(公告)日：2005-06-23

    申请号：US10920736

    申请日：2004-08-17

    申请人： Amr Salahieh ,  Brian Brandt ,  Dwight Morejohn ,  Kenneth Michlitsch ,  Tom Saul

    发明人： Amr Salahieh ,  Brian Brandt ,  Dwight Morejohn ,  Kenneth Michlitsch ,  Tom Saul

    IPC分类号： A61F2/01 ,  A61F2/06 ,  A61F2/24

    CPC分类号： A61F2/013 ,  A61F2/2418 ,  A61F2/2439 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/008

    摘要： Apparatus for protecting a patient against embolization during endovascular replacement of the patient's heart valve is provided, the apparatus including a replacement valve configured for endovascular delivery and deployment, and an embolic filter configured for disposal downstream of the replacement valve during deployment of the valve. Apparatus including a delivery catheter having an expandable replacement valve disposed therein, and an embolic filter advanceable along the delivery catheter for diverting emboli released during endovascular deployment of the replacement valve is also provided. Furthermore, methods for protecting a patient against embolization during endovascular replacement of the patient's heart valve are provided, the methods including the steps of endovascularly delivering a replacement valve to a vicinity of the patient's heart valve, endovascularly deploying an embolic filter downstream of the heart valve, and endovascularly deploying the replacement valve.

    摘要翻译： 提供了一种用于在血管内置换患者心脏瓣膜期间保护患者免受栓塞的装置，该装置包括构造成用于血管内递送和展开的置换瓣膜，以及构造成用于在阀的展开期间在置换瓣膜的下游处置的栓塞过滤器。 还提供了包括具有设置在其中的可扩张置换瓣膜的输送导管和沿着输送导管可推进的栓塞过滤器的装置，还提供了在置换瓣膜的血管内展开期间释放的栓塞。 此外，提供了在患者心脏瓣膜的血管内置换期间保护患者免受栓塞的方法，所述方法包括将置换瓣膜血管内输送到患者心脏瓣膜附近的步骤，在心脏瓣膜下游血管内部署栓塞过滤器 ，并且血管内部署更换瓣膜。

    Everting heart valve
    2.
    发明申请
    Everting heart valve 有权
    永恒心脏瓣膜

    公开(公告)号：US20050283231A1

    公开(公告)日：2005-12-22

    申请号：US10870340

    申请日：2004-06-16

    申请人： Ulrich Haug ,  Hans Valencia ,  Robert Geshlider ,  Tom Saul ,  Amr Salahieh ,  Dwight Morejohn ,  Kenneth Michlitsch

    发明人： Ulrich Haug ,  Hans Valencia ,  Robert Geshlider ,  Tom Saul ,  Amr Salahieh ,  Dwight Morejohn ,  Kenneth Michlitsch

    IPC分类号： A61F2/24 ,  A61F2/90

    CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2220/0016 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0065 ,  A61F2230/0078

    摘要： The present invention provides methods and apparatus for endovascularly replacing a patient's heart valve. The apparatus includes a replacement valve and an expandable anchor configured for endovascular delivery to a vicinity of the patient's heart valve. In some embodiments, the replacement valve is adapted to wrap about the anchor, for example, by everting during endovascular deployment. In some embodiments, the replacement valve is not connected to expandable portions of the anchor. In some embodiments, the anchor is configured for active foreshortening during endovascular deployment. In some embodiments, the anchor includes expandable lip and skirt regions for engaging the patient's heart valve during deployment. In some embodiments, the anchor comprises a braid fabricated from a single strand of wire. In some embodiments, the apparatus includes a lock configured to maintain anchor expansion. The invention also includes methods for endovascularly replacing a patient's heart valve. In some embodiments, the method includes the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve, wrapping at least a portion of the replacement valve about the anchor, and expanding the anchor to a deployed configuration.

    摘要翻译： 本发明提供了用于血管内替代患者心脏瓣膜的方法和装置。 该装置包括置换瓣膜和可扩张锚固件，其可构造成用于血管内递送至患者心脏瓣膜附近。 在一些实施例中，替换瓣膜适于例如在血管内部署过程中绕过锚固件。 在一些实施例中，替换阀不连接到锚的可膨胀部分。 在一些实施例中，锚定构件用于在血管内部署过程中进行主动缩短。 在一些实施例中，锚固件包括用于在展开期间与患者的心脏瓣膜接合的可扩张唇缘和裙部区域。 在一些实施例中，锚固件包括由单股线制成的编织物。 在一些实施例中，该装置包括被配置成保持锚固扩展的锁。 本发明还包括用于血管内替代患者心脏瓣膜的方法。 在一些实施例中，该方法包括以下步骤：将置换瓣膜和可膨胀锚固件血管内输送到心脏瓣膜附近，将替代瓣膜的至少一部分围绕锚定件包裹，并将锚固件扩展至展开构造。

    Medical implant delivery and deployment tool
    7.
    发明授权
    Medical implant delivery and deployment tool 有权
    医疗植入物交付和部署工具

    公开(公告)号：US07824443B2

    公开(公告)日：2010-11-02

    申请号：US11275912

    申请日：2006-02-02

    申请人： Amr Salahieh ,  Dwight Morejohn ,  Ulrich R. Haug ,  Brian Brandt ,  Hans Valencia ,  Tom Saul

    发明人： Amr Salahieh ,  Dwight Morejohn ,  Ulrich R. Haug ,  Brian Brandt ,  Hans Valencia ,  Tom Saul

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2439 ,  A61B17/068 ,  A61B2017/00243 ,  A61F2/2418 ,  A61F2/90 ,  A61F2002/9517

    摘要： An apparatus for endovascularly replacing a patient's heart valve. In some embodiments, the apparatus includes a replacement heart valve implant comprising a valve and an expandable anchor; and a deployment tool adapted to endovascularly deliver the replacement heart valve implant to an implant site within the patient, the deployment tool comprising an actuator adapted to exert an axially directed force on the anchor. The invention also provides a method for endovascularly replacing a heart valve of a patient. In some embodiments, the method includes the steps of endovascularly delivering a replacement heart valve implant having a valve and an anchor to an implant site within the patient; and applying an axially directed force from an actuator outside of the patient to the anchor. In invention also provides deployment tools for performing the method.

    摘要翻译： 用于血管内置换患者心脏瓣膜的装置。 在一些实施例中，该装置包括置换心脏瓣膜植入体，其包括阀和可扩张锚; 以及适于将替代心脏瓣膜植入物血管内输送到患者体内的植入部位的部署工具，所述展开工具包括适于在锚固件上施加轴向力的致动器。 本发明还提供一种用于血管内替换患者心脏瓣膜的方法。 在一些实施例中，该方法包括以下步骤：血管内递送具有瓣膜和锚的置换心脏瓣膜植入物到患者体内的植入部位; 以及将来自所述患者外部的致动器的轴向力施加到所述锚固件。 本发明还提供了用于执行该方法的部署工具。

    Medical Implant Delivery And Deployment Tool
    8.
    发明申请
    Medical Implant Delivery And Deployment Tool 有权
    医疗植入物交付和部署工具

    公开(公告)号：US20060173524A1

    公开(公告)日：2006-08-03

    申请号：US11275912

    申请日：2006-02-02

    申请人： Amr Salahieh ,  Dwight Morejohn ,  Ulrich Haug ,  Brian Brandt ,  Hans Valencia ,  Tom Saul

    发明人： Amr Salahieh ,  Dwight Morejohn ,  Ulrich Haug ,  Brian Brandt ,  Hans Valencia ,  Tom Saul

    IPC分类号： A61F2/06

    CPC分类号： A61F2/2439 ,  A61B17/068 ,  A61B2017/00243 ,  A61F2/2418 ,  A61F2/90 ,  A61F2002/9517

    摘要： An apparatus for endovascularly replacing a patient's heart valve. In some embodiments, the apparatus includes a replacement heart valve implant comprising a valve and an expandable anchor; and a deployment tool adapted to endovascularly deliver the replacement heart valve implant to an implant site within the patient, the deployment tool comprising an actuator adapted to exert an axially directed force on the anchor. The invention also provides a method for endovascularly replacing a heart valve of a patient. In some embodiments, the method includes the steps of endovascularly delivering a replacement heart valve implant having a valve and an anchor to an implant site within the patient; and applying an axially directed force from an actuator outside of the patient to the anchor. In invention also provides deployment tools for performing the method.

    摘要翻译： 用于血管内置换患者心脏瓣膜的装置。 在一些实施例中，该装置包括置换心脏瓣膜植入体，其包括阀和可扩张锚; 以及适于将替代心脏瓣膜植入物血管内输送到患者体内的植入部位的部署工具，所述展开工具包括适于在锚固件上施加轴向力的致动器。 本发明还提供一种用于血管内替换患者心脏瓣膜的方法。 在一些实施例中，该方法包括以下步骤：血管内递送具有瓣膜和锚的置换心脏瓣膜植入物到患者体内的植入部位; 以及将来自所述患者外部的致动器的轴向力施加到所述锚固件。 本发明还提供了用于执行该方法的部署工具。

    Methods and apparatus for endovascularly replacing a heart valve
    10.
    发明申请
    Methods and apparatus for endovascularly replacing a heart valve 有权
    血管内置换心脏瓣膜的方法和装置

    公开(公告)号：US20050137699A1

    公开(公告)日：2005-06-23

    申请号：US10982692

    申请日：2004-11-05

    申请人： Amr Salahieh ,  Hans Valencia ,  Brian Brandt ,  Claudio Argento ,  Ulrich Haug ,  Jean-Pierre Dueri ,  Daniel Hildebrand ,  Dwight Morejohn ,  Tom Saul

    发明人： Amr Salahieh ,  Hans Valencia ,  Brian Brandt ,  Claudio Argento ,  Ulrich Haug ,  Jean-Pierre Dueri ,  Daniel Hildebrand ,  Dwight Morejohn ,  Tom Saul

    IPC分类号： A61F2/06 ,  A61F2/24 ,  A61F2/90

    CPC分类号： A61F2/2418 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2002/9528 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2250/006

    摘要： The invention includes methods of and apparatus for endovascularly replacing a heart valve of a patient. One aspect of the invention provides a method including the steps of endovascularly delivering a replacement valve and an expandable anchor in an unexpanded configuration within a sheath to a vicinity of the heart valve; deploying the anchor from the sheath; expanding the anchor with a deployment tool comprising a plurality of actuation elements to contact tissue at an anchor site; and retrieving the anchor into the sheath. Another aspect of the invention provides apparatus including a sheath; a deployment tool comprising a plurality of anchor actuation elements; a replacement valve configured to be disposed within the sheath for delivery to a vicinity of the heart valve; and an expandable anchor configured to be disposed within the sheath for delivery to the vicinity of the heart valve, to be deployed from the sheath, to be expanded by the deployment tool to contact tissue at an anchor site and to be retrieved back into the sheath after having been expanded.

    摘要翻译： 本发明包括用于血管内置换患者心脏瓣膜的方法和装置。 本发明的一个方面提供了一种方法，包括以下步骤：血管内递送替代瓣膜和可膨胀锚固件，所述替换瓣膜和可扩张锚固件处于护套内的未膨胀构型至心脏瓣膜附近; 从护套部署锚; 使用包括多个致动元件的展开工具来扩展锚，以在锚定位置处接触组织; 并将锚固件收回到护套中。 本发明的另一方面提供了一种包括护套的装置; 包括多个锚致动元件的展开工具; 配置成设置在所述护套内用于输送到所述心脏瓣膜附近的置换瓣膜; 以及被构造成设置在所述护套内以用于输送到所述心脏瓣膜附近的可扩张锚，以从所述鞘部署，以由所述展开工具扩张以在锚定位置处接触组织并被回收到所述鞘中 在扩大后。