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公开(公告)号:US20100135954A1
公开(公告)日:2010-06-03
申请号:US12597275
申请日:2008-04-25
申请人: Amy L. Tsuhako , Naing Aay , S. David Brown , Wai Ki Vicky Chan , Hongwang Du , Ping Huang , Brian Kane , Patrick Kearney , Moon Hwan Kim , Elena S. Koltun , Michael Pack , Wei Xu , Peiwen Zhou
发明人: Amy L. Tsuhako , Naing Aay , S. David Brown , Wai Ki Vicky Chan , Hongwang Du , Ping Huang , Brian Kane , Patrick Kearney , Moon Hwan Kim , Elena S. Koltun , Michael Pack , Wei Xu , Peiwen Zhou
IPC分类号: A61K38/20 , A61K38/21 , A61K31/567 , A61K31/5377 , A61K31/496 , A61K31/506 , C07D413/02 , C07D403/10 , C07D401/10 , A61P35/00
CPC分类号: C07D213/64 , C07D239/36 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要: A compound having Formula I or II (Formula I) or (Formula II), or a pharmaceutically acceptable salt thereof, wherein X, Z, R1, R2, R11 and R12 are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof.
摘要翻译: 具有式I或II(式I)或(式II)的化合物或其药学上可接受的盐,其中X,Z,R 1,R 2,R 11和R 12如说明书中所定义; 其药物组合物; 及其使用方法。
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公开(公告)号:US08242129B2
公开(公告)日:2012-08-14
申请号:US12597275
申请日:2008-04-25
申请人: Amy L. Tsuhako , Naing Aay , S. David Brown , Wai Ki Vicky Chan , Hongwang Du , Ping Huang , Brian Kane , Patrick Kearney , Moon Hwan Kim , Elena S. Koltun , Michael Pack , Wei Xu , Peiwen Zhou
发明人: Amy L. Tsuhako , Naing Aay , S. David Brown , Wai Ki Vicky Chan , Hongwang Du , Ping Huang , Brian Kane , Patrick Kearney , Moon Hwan Kim , Elena S. Koltun , Michael Pack , Wei Xu , Peiwen Zhou
IPC分类号: A61K31/505
CPC分类号: C07D213/64 , C07D239/36 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要: A compound having Formula I or II (Formula I) or (Formula II), or a pharmaceutically acceptable salt thereof, wherein X, Z, R1, R2, R11 and R12 are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof.
摘要翻译: 具有式I或II(式I)或(式II)的化合物或其药学上可接受的盐,其中X,Z,R 1,R 2,R 11和R 12如说明书中所定义; 其药物组合物; 及其使用方法。
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公开(公告)号:US08324231B2
公开(公告)日:2012-12-04
申请号:US12597271
申请日:2008-04-24
申请人: Elena S. Koltun , Patrick Kearney , Naing Aay , Arlyn Arcalas , Wai Ki Vicky Chan , Jeffry Kimo Curtis , Hongwang Du , Ping Huang , Brian Kane , Moon Hwan Kim , Michael Pack , Amy L. Tsuhako , Wei Xu , Cristiana A. Zaharia , Peiwen Zhou
发明人: Elena S. Koltun , Patrick Kearney , Naing Aay , Arlyn Arcalas , Wai Ki Vicky Chan , Jeffry Kimo Curtis , Hongwang Du , Ping Huang , Brian Kane , Moon Hwan Kim , Michael Pack , Amy L. Tsuhako , Wei Xu , Cristiana A. Zaharia , Peiwen Zhou
IPC分类号: A01N43/54 , A61K31/505
CPC分类号: C07D405/04 , C07D403/04 , C07D413/04 , C07D417/04
摘要: A compound having Formula I: or a pharmaceutically acceptable salt thereof, wherein X, R, R and R are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof. The compounds of Formula I are inhibitors of Casein kinase II (CK2) pathways.
摘要翻译: 具有式I的化合物或其药学上可接受的盐,其中X,R,R和R如说明书中所定义; 其药物组合物; 及其使用方法。 式I的化合物是酪蛋白激酶II(CK2)途径的抑制剂。
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公开(公告)号:US20100144770A1
公开(公告)日:2010-06-10
申请号:US12597271
申请日:2008-04-24
申请人: Elena S. Koltun , Patrick Kearney , Naing Aay , Arlyn Arcalas , Wai Ki Vicky Chan , Jeffry Kimo Curtis , Hongwang Du , Ping Huang , Brian Kane , Moon Hwan Kim , Michael Pack , Amy L. Tsuhako , Wei Xu , Cristiana A. Zaharia , Peiwen Zhou
发明人: Elena S. Koltun , Patrick Kearney , Naing Aay , Arlyn Arcalas , Wai Ki Vicky Chan , Jeffry Kimo Curtis , Hongwang Du , Ping Huang , Brian Kane , Moon Hwan Kim , Michael Pack , Amy L. Tsuhako , Wei Xu , Cristiana A. Zaharia , Peiwen Zhou
IPC分类号: A61K31/506 , C07D239/36 , C07D401/10 , A61K31/4439 , A61P35/00
CPC分类号: C07D405/04 , C07D403/04 , C07D413/04 , C07D417/04
摘要: A compound having Formula I: or a pharmaceutically acceptable salt thereof, wherein X, R, R and R are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof. The compounds of Formula I are inhibitors of Casein kinase II (CK2) pathways.
摘要翻译: 具有式I的化合物或其药学上可接受的盐,其中X,R,R和R如说明书中所定义; 其药物组合物; 及其使用方法。 式I的化合物是酪蛋白激酶II(CK2)途径的抑制剂。
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公开(公告)号:US20090247559A1
公开(公告)日:2009-10-01
申请号:US12341210
申请日:2008-12-22
申请人: S. David Brown , Hongwang Du , Maurizio Franzini , Adam Antoni Galan , Ping Huang , Patrick Kearney , Moon Hwan Kim , Elena S. Koltun , Steven James Richards , Amy L. Tsuhako , Cristiana A. Zaharia
发明人: S. David Brown , Hongwang Du , Maurizio Franzini , Adam Antoni Galan , Ping Huang , Patrick Kearney , Moon Hwan Kim , Elena S. Koltun , Steven James Richards , Amy L. Tsuhako , Cristiana A. Zaharia
IPC分类号: A61K31/519 , C07D487/04 , A61P35/00
CPC分类号: C07D491/04
摘要: A compound according to formula I: or a pharmaceutically acceptable salt thereof; wherein R1, R2, R3a, R3b, R3c and R3d are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译: 根据式I的化合物或其药学上可接受的盐; 其中R1,R2,R3a,R3b,R3c和R3d如说明书中所定义,其药物组合物及其使用方法。
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