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公开(公告)号：US07192952B2
公开(公告)日：2007-03-20
申请号：US11070056
申请日：2005-03-02
申请人： Anders Bendtz Kanstrup , Christian Klarner Sams , Jane Marie Lundbeck , Lise Brown Christiansen , Marit Kristiansen
发明人： Anders Bendtz Kanstrup , Christian Klarner Sams , Jane Marie Lundbeck , Lise Brown Christiansen , Marit Kristiansen
IPC分类号： C07D473/08 , C07D473/06 , A61K31/522 , A61K31/55 , A61P3/10
CPC分类号： C07D473/00 , C07D473/02
摘要： The present invention relates to therapeutically active and selective inhibitors of the enzyme DPP-IV of formula I, pharmaceutical compositions comprising the compounds and the use of such compounds for and the manufacture of medicaments for treating diseases that are associated with proteins that are subject to inactivation by DPP-IV, such as type 2 diabetes and obesity
摘要翻译： 本发明涉及式I的DPP-IV酶的治疗活性和选择性抑制剂，包含该化合物的药物组合物和这些化合物在制备用于治疗与被灭活的蛋白质相关的疾病的药物中的用途 通过DPP-IV，如2型糖尿病和肥胖
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公开(公告)号：US06869947B2
公开(公告)日：2005-03-22
申请号：US10186498
申请日：2002-06-28
申请人： Anders Bendtz Kanstrup , Christian Klarner Sams , Jane Marie Lundbeck , Lise Brown Christiansen , Marit Kristiansen
发明人： Anders Bendtz Kanstrup , Christian Klarner Sams , Jane Marie Lundbeck , Lise Brown Christiansen , Marit Kristiansen
IPC分类号： A61P3/10 , C07D473/00 , C07D473/02 , C07D473/08 , A61K31/522 , A61K31/55 , C07D473/06
CPC分类号： C07D473/00 , C07D473/02
摘要： The present invention relates to therapeutically active and selective inhibitors of the enzyme DPP-IV of formula I, pharmaceutical compositions comprising the compounds and the use of such compounds for and the manufacture of medicaments for treating diseases that are associated with proteins that are subject to inactivation by DPP-IV, such as type 2 diabetes and obesity
摘要翻译： 本发明涉及式I的DPP-IV酶的治疗活性和选择性抑制剂，包含该化合物的药物组合物和这些化合物在制备用于治疗与被灭活的蛋白质相关的疾病的药物中的用途 通过DPP-IV，如2型糖尿病和肥胖
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公开(公告)号：US07235538B2
公开(公告)日：2007-06-26
申请号：US10621302
申请日：2003-07-17
申请人： Anders Bendtz Kanstrup , Lise Brown Christiansen , Jane Marie Lundbeck , Christian K. Sams , Marit Kristiansen
发明人： Anders Bendtz Kanstrup , Lise Brown Christiansen , Jane Marie Lundbeck , Christian K. Sams , Marit Kristiansen
IPC分类号： A61K31/522 , A61K3/10 , A61K3/04 , C07D473/08 , C07D473/06
CPC分类号： C07D473/04 , C07D473/08
摘要： The present invention relates to therapeutically active and selective inhibitors of the enzyme DPP-IV, which are of formula I wherein each n is one or two independently and R1, R2, R3, R6, R7, R9, and R10 are defined herein. The present invention also relates to pharmaceutical compositions comprising the compounds of formula I and the use of the compounds for treating diseases that are associated with proteins that are subject to inactivation by DPP-IV, such as type-2 diabetes and obesity.
摘要翻译： 本发明涉及酶DPP-IV的治疗活性和选择性抑制剂，其具有式I，其中每个n独立地为一个或两个，R 1，R 2， R 3，R 6，R 7，R 9，R 9和R 10， >在本文中定义。 本发明还涉及包含式I化合物的药物组合物和该化合物用于治疗与通过DPP-IV失活的蛋白质例如2型糖尿病和肥胖相关的疾病的用途。
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4.发明授权公开(公告)号：US06645995B2
公开(公告)日：2003-11-11
申请号：US10076577
申请日：2002-02-08
IPC分类号： A61K314025
CPC分类号： C07D401/06 , A61K31/00 , A61K31/40 , A61K31/44 , A61K31/4439 , C07D207/16 , C07D207/22 , C07D401/12 , C07D403/06 , C07D417/06
摘要： Described are compounds of formula I wherein at least one of the bonds in the five-membered ring is a double bond; B is any alpha or beta amino acid connected to the ring with an amide or peptide bond; or a salt thereof with a pharmaceutically acceptable acid or base. Pharmaceutical compositions containing these compounds are also described. These compounds are useful for treating type II diabetes.
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5.发明授权Therapeutically active and selective heterocyclic compounds that are inhibitors of the enzyme DPP-IV 失效作为DPP-IV酶抑制剂的治疗活性和选择性杂环化合物公开(公告)号：US06380398B2
公开(公告)日：2002-04-30
申请号：US09767354
申请日：2001-01-23
IPC分类号： C07D20718
CPC分类号： C07D401/06 , A61K31/00 , A61K31/40 , A61K31/44 , A61K31/4439 , C07D207/16 , C07D207/22 , C07D401/12 , C07D403/06 , C07D417/06
摘要： Described are compounds of formula I wherein at least one of the bonds in the five-membered ring is a double bond; B is any alpha or beta amino acid connected to the ring with an amide or peptide bond; or a salt thereof with a pharmaceutically acceptable acid or base. Pharmaceutical compositions containing these compounds are also described. These compounds are useful for treating type II diabetes.
摘要翻译： 描述的是式I的化合物，其中五元环中的至少一个键是双键; B是与酰胺或肽键连接到环上的任何α或β氨基酸; 或其盐与药学上可接受的酸或碱反应。 还描述了含有这些化合物的药物组合物。 这些化合物可用于治疗II型糖尿病。
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公开(公告)号：US20120165375A1
公开(公告)日：2012-06-28
申请号：US13415000
申请日：2012-03-08
申请人： Anthony Murray , Jasper Lau , Per Vedsø , Lise Brown Christiansen
发明人： Anthony Murray , Jasper Lau , Per Vedsø , Lise Brown Christiansen
IPC分类号： A61K31/426 , A61P3/10 , C07D277/54
CPC分类号： C07D277/48
摘要： This application relates to novel urea glucokinase activators and use of the compounds of the invention for preparation of a medicament for the treatment of various diseases, e.g. for the treatment of type 2 diabetes. Further encompassed is a pharmaceutical composition comprising a compound according to the invention and a process for preparing such.
摘要翻译： 本申请涉及新型尿素葡萄糖激酶激活剂和本发明化合物在制备用于治疗各种疾病的药物中的用途。 用于治疗2型糖尿病。 进一步包括的是包含根据本发明的化合物和其制备方法的药物组合物。
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7.发明授权2-(2-hydroxyphenyl)benzimidazoles useful for treating obesity and diabetes 失效用于治疗肥胖和糖尿病的2-（2-羟基苯基）苯并咪唑公开(公告)号：US07915299B2
公开(公告)日：2011-03-29
申请号：US12515049
申请日：2007-11-15
申请人： Anders Klarskov Petersen , Preben Houlberg Olesen , Lise Brown Christiansen , Holger Claus Hansen , Flemming Elmelund Nielsen
发明人： Anders Klarskov Petersen , Preben Houlberg Olesen , Lise Brown Christiansen , Holger Claus Hansen , Flemming Elmelund Nielsen
IPC分类号： A61K31/4184 , C07D235/18
CPC分类号： C07D235/18
摘要： The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful, inter alia, in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.
摘要翻译： 本发明涉及用作化学解偶联剂的新型化合物。 本发明的化合物尤其可用于治疗，包括预防肥胖症，糖尿病和与其相关的许多疾病或病症。
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8.发明授权Pyrrolo[2,1,5-cd]indolizine derivatives useful in the prevention or treatment of estrogen related diseases or syndromes 失效可用于预防或治疗雌激素相关疾病或综合征的吡咯并[2,1,5-cd]中氮茚衍生物
公开(公告)号：US6080754A
公开(公告)日：2000-06-27
申请号：US88404
申请日：1998-06-01
申请人： Anker Steen Jorgensen , Poul Jacobsen , Lise Brown Christiansen , Paul Stanley Bury , Anders Kanstrup
发明人： Anker Steen Jorgensen , Poul Jacobsen , Lise Brown Christiansen , Paul Stanley Bury , Anders Kanstrup
IPC分类号： C07D491/22 , A61K31/437 , A61P3/04 , A61P3/10 , A61P5/00 , A61P9/00 , A61P13/00 , A61P13/08 , A61P15/00 , A61P15/06 , A61P15/12 , A61P17/10 , A61P19/08 , A61P19/10 , A61P25/24 , A61P25/28 , A61P35/00 , A61P43/00 , C07D471/04 , C07D471/16 , A61K31/44 , C07D471/12
CPC分类号： C07D471/16
摘要： The present invention relates to therapeutically active compounds of formula I ##STR1## a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in the prevention or treatment of estrogen related diseases or syndromes.
摘要翻译： 本发明涉及治疗活性的式I化合物，其制备方法和包含该化合物的药物组合物。 新型化合物可用于预防或治疗雌激素相关疾病或综合征。
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9.发明申请HALOALKYLSULFONE SUBSTITUTED COMPOUNDS USEFUL FOR TREATING OBESITY AND DIABETES 失效用于治疗肥胖和糖尿病的HALOALKYLSULFONE替代化合物公开(公告)号：US20100113536A1
公开(公告)日：2010-05-06
申请号：US12515045
申请日：2007-11-15
申请人： Anders Klarskov Petersen , Preben Houlberg Olesen , Lise Brown Christiansen , Flemming Elmelund Nielsen
发明人： Anders Klarskov Petersen , Preben Houlberg Olesen , Lise Brown Christiansen , Flemming Elmelund Nielsen
IPC分类号： A61K31/44 , A61K31/42 , C07D213/06 , C07D261/08 , A61P3/04 , A61P3/06 , A61P9/10 , A61P9/12 , A61P3/10
CPC分类号： C07D261/08 , C07D213/56
摘要： The present invention relates to novel compounds of formula [I], wherein R1 represents heteroaryl, at least one substituent among R5, R6 and R7 represent —SR12, —S(O)R12 or —S(O)2R12 and the remaining substituents are as defined in the claims, that act as chemical uncouplers. Compounds of the invention are useful inter alia, in the treatment, including prevention, of obesity, diabetes and a number of diseases associated therewith.
摘要翻译： 本发明涉及新的式[I]化合物，其中R 1表示杂芳基，R 5，R 6和R 7中的至少一个取代基表示-SR 12，-S（O）R 12或-S（O） 如权利要求中所定义，其用作化学解偶联剂。 本发明的化合物尤其可用于治疗，包括预防肥胖症，糖尿病和与其相关的许多疾病。
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公开(公告)号：US20100075932A1
公开(公告)日：2010-03-25
申请号：US12625068
申请日：2009-11-24
IPC分类号： A61K31/609 , A61P3/04 , A61P25/00 , A61P1/00 , A61P35/00 , A61P9/10 , A61P9/12 , C07C235/56 , C07C255/50
CPC分类号： C07D333/60 , C07C235/64 , C07C255/60 , C07D333/38
摘要： Novel salicylic anilides are chemical uncouplers useful e.g. for the treatment of obesity.
摘要翻译： 新型水杨酸酯是化学解偶联剂，例如有用的。 用于治疗肥胖。
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