利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

1 条记录 (耗时 0.027 秒)

    Condensed quinolinium and isoquinolinium derivatives
    1.
    发明授权
    Condensed quinolinium and isoquinolinium derivatives 失效
    浓缩的喹啉和异喹啉衍生物

    公开(公告)号：US4994448A

    公开(公告)日：1991-02-19

    申请号：US251445

    申请日：1988-09-30

    申请人： Andras Messmer ,  Gyorgy Hajos ,  Zsuzsa Juhasz nee Riedl ,  Pal Benko ,  Laszlo Pallos ,  Lujza Petocz ,  Eniko Szirt nee Kiszelly ,  Gabor Gigler ,  Istvan Gyertyan ,  Maria Hegedus

    发明人： Andras Messmer ,  Gyorgy Hajos ,  Zsuzsa Juhasz nee Riedl ,  Pal Benko ,  Laszlo Pallos ,  Lujza Petocz ,  Eniko Szirt nee Kiszelly ,  Gabor Gigler ,  Istvan Gyertyan ,  Maria Hegedus

    IPC分类号： A61K31/53 ,  A61P25/02 ,  A61P25/04 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D471/04

    CPC分类号： C07D471/04

    摘要： The new compounds of the general Formula I ##STR1## (wherein R.sub.1 stands for C.sub.1-4 alkyl or aralkyl; andR.sub.2 represents hydroxy; orR.sub.1 and R.sub.2 together form a valency bond;R.sub.3 is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, phenyl, amino, alkylthio or a group of the Formula --NR.sub.7 R.sub.8 in which R.sub.7 and R.sub.8 may be the same or different and stand for hydrogen, C.sub.1-4 alkyl, phenyl-C.sub.1-4 alkyl, hydroxy-C.sub.1-4 alkyl or di-(C.sub.1-4 alkyl)-amino-C.sub.1-4 alkyl or together with the nitrogen atom they are attached to form a 6-membered heterocyclic ring which may optionally contain a further nitrogen, oxygen or sulfur atom; orR.sub.2 and R.sub.3 together form an oxo (.dbd.O) or thixo (.dbd.S) group;R.sub.4 represents hydrogen, C.sub.1-4 alkyl or phenyl which may optionally bear one or two halogen or nitro substituent(s);Z is a group of the Formula (a) or (b) ##STR2## A.sup.- represents an anion) and isomers thereof possess useful local anaesthetic, antidepressant, tranquillo-sedative and smooth muscle relaxant properties accompanied by a weaker analgesic effect and are useful in therapy.

    摘要翻译： 通式I的新化合物Ⅰ（其中R1代表C1-4烷基或芳烷基，R2代表羟基;或R1和R2一起形成价键; R3是氢，C1-4烷基，C1- 烷氧基，苯基，氨基，烷硫基或式-NR7R8的基团，其中R 7和R 8可以相同或不同，代表氢，C 1-4烷基，苯基-C 1-4烷基，羟基-C 1-4烷基 或二 - （C 1-4烷基） - 氨基-C 1-4烷基或与它们连接的氮原子一起形成可任选地含有另外的氮，氧或硫原子的6元杂环;或R 2和R 3 一起形成氧代（= O）或触变（= S）基团; R4代表氢，C1-4烷基或苯基，其可任选地带有一个或两个卤素或硝基取代基; Z是式（a ）或（b）和A-表示阴离子）及其异构体具有有用的局部麻醉剂，抗抑郁药，镇痛镇痛和平滑肌松弛剂性质，伴随较弱的镇痛剂 c效应，可用于治疗。