公开(公告)号：US07524681B2

公开(公告)日：2009-04-28

申请号：US10466848

申请日：2002-01-22

申请人： Andreas Wolf ,  Ralf Masuch ,  Robert Seidel

发明人： Andreas Wolf ,  Ralf Masuch ,  Robert Seidel

IPC分类号： G01N33/50 ,  G01N21/35 ,  G01J3/42

CPC分类号： G01N21/3563 ,  G01N21/35 ,  G01N2021/3595 ,  Y10S436/811 ,  Y10S436/812 ,  Y10S436/813 ,  Y10S436/814 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/14 ,  Y10T436/146666 ,  Y10T436/147777 ,  Y10T436/25125 ,  Y10T436/25375

摘要： The present invention relates to a method for determining the condition of a biological fluid by recording the IR spectrum of a sample of the biological fluid. To this end, the biological fluid can be examined in its native form. The method of the invention is usable, for example, for detecting pathological conditions in organisms.

摘要翻译： 本发明涉及通过记录生物流体样品的红外光谱来确定生物流体状况的方法。 为此，可以以其天然形式检查生物流体。 本发明的方法可用于例如用于检测生物体中的病理状况。

公开(公告)号：US06429015B1

公开(公告)日：2002-08-06

申请号：US09508416

申请日：2000-05-22

申请人： David Moss ,  Herbert Platsch ,  Kathrin Füchsle ,  Ralf Masuch

发明人： David Moss ,  Herbert Platsch ,  Kathrin Füchsle ,  Ralf Masuch

IPC分类号： G01N2135

CPC分类号： G01N33/68 ,  G01N1/14 ,  G01N21/3577 ,  G01N35/08 ,  G01N35/1097 ,  Y10T436/143333

摘要： The invention relates to a method and a device for identifying active substances in order to determine the formation of complexes between reactants. According to the inventive method, at least two reactants are mixed and made to react to form a complex. The infrared spectrum of the individual reactants which have not yet been reacted in the mixture is measured during a first time interval and at least a second infrared measurement is conducted to measure the complex formed by the reactants during a second interval. The difference between the two spectra measured during different moments is then determined. The reactants whose differential spectrum exhibits a band structure are selected as active substances.

摘要翻译： 本发明涉及一种用于鉴定活性物质以确定反应物之间复合物形成的方法和装置。 根据本发明的方法，将至少两种反应物混合并使其反应以形成络合物。 在第一时间间隔内测量在混合物中尚未反应的各个反应物的红外光谱，并进行至少第二次红外测量以测量在第二时间间隔期间由反应物形成的络合物。 然后确定在不同时刻测量的两个光谱之间的差异。 选择差示光谱显示带结构的反应物作为活性物质。

公开(公告)号：US07479197B2

公开(公告)日：2009-01-20

申请号：US10530956

申请日：2003-10-08

申请人： Ralf Masuch

发明人： Ralf Masuch

IPC分类号： C03C27/00 ,  G01N21/00 ,  G01N21/49 ,  G01N21/85

CPC分类号： G01N21/05 ,  G01N2021/0346

摘要： The invention relates to a process for producing a flow cell for the spectroscopic analysis of samples to be passed through, the process comprising the following steps: (a) provision of a first (10) and of a second (22) window, the second window (22) having at least two sample flow channels (24) for supplying and removing the sample to be analyzed; (b) application of a structured thin layer (18) to one of the windows (10, 22); (c) contacting and liquid-tight securing of the thin layer (18) to the other (22, 10) window, in such a way that facing, plane-parallel window surfaces (14, 20) of the windows (10, 22) and the thin layer (18) delimit a flow chamber (26) which is accessible only through the sample flow channels (24), the windows (10, 22) being optically transparent at least in some regions at least in the region of the flow chamber (26); and (d) filling at least some regions of a filling chamber (28) between the windows (10, 22) which is separated from the flow chamber (26) by the thin layer (18) and adjoins the structured thin layer (18) with adhesive.

摘要翻译： 本发明涉及一种用于生产待通过的样品的光谱分析的流通池的方法，该方法包括以下步骤：（a）提供第一（10）和第二（22）窗口，第二 窗口（22）具有至少两个用于提供和去除要分析的样品的样品流动通道（24）; （b）将结构化薄层（18）施加到窗口（10,22）之一; （c）将所述薄层（18）与所述另一个（22,10）窗口接触和液密地固定，使得所述窗口（10,22）的平面平行的窗表面（14,20）面对 ），并且薄层（18）限定仅可通过样品流动通道（24）访问的流动室（26），窗口（10,22）至少在至少一些区域中至少在某些区域中是光学透明的 流动室（26）; 并且（d）在通过所述薄层（18）与所述流动室（26）分离的所述窗口（10,22）之间填充填充室（28）的至少一些区域并与所述结构化薄层（18）相邻， 用粘合剂。

公开(公告)号：US20060175732A1

公开(公告)日：2006-08-10

申请号：US10530956

申请日：2003-10-08

申请人： Ralf Masuch

发明人： Ralf Masuch

IPC分类号： B32B37/00

CPC分类号： G01N21/05 ,  G01N2021/0346

摘要： The invention relates to a process for producing a flow cell for the spectroscopic analysis of samples to be passed through, the process comprising the following steps: (a) provision of a first (10) and of a second (22) window, the second window (22) having at least two sample flow channels (24) for supplying and removing the sample to be analyzed; (b) application of a structured thin layer (18) to one of the windows (10, 22); (c) contacting and liquid-tight securing of the thin layer (18) to the other (22, 10) window, in such a way that facing, plane-parallel window surfaces (14, 20) of the windows (10, 22) and the thin layer (18) delimit a flow chamber (26) which is accessible only through the sample flow channels (24), the windows (10, 22) being optically transparent at least in some regions at least in the region of the flow chamber (26); and (d) filling at least some regions of a filling chamber (28) between the windows (10, 22) which is separated from the flow chamber (26) by the thin layer (18) and adjoins the structured thin layer (18) with adhesive.

摘要翻译： 本发明涉及一种用于生产待通过的样品的光谱分析的流通池的方法，该方法包括以下步骤：（a）提供第一（10）和第二（22）窗口，第二 窗口（22）具有至少两个用于提供和去除要分析的样品的样品流动通道（24）; （b）将结构化薄层（18）施加到窗口（10,22）之一; （c）将所述薄层（18）与所述另一个（22,10）窗口接触和液密地固定，使得所述窗口（10,22）的平面平行的窗表面（14,20）面对 ），并且薄层（18）限定仅可通过样品流动通道（24）访问的流动室（26），窗口（10,22）至少在至少一些区域中至少在某些区域中是光学透明的 流动室（26）; 并且（d）在通过所述薄层（18）与所述流动室（26）分离的所述窗口（10,22）之间填充填充室（28）的至少一些区域并与所述结构化薄层（18）相邻， 用粘合剂。