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1.发明申请公开(公告)号：US20130190196A1
公开(公告)日：2013-07-25
申请号：US13580618
申请日：2011-02-24
申请人： Andrew B. Onderdonk , Amy Barczak , Deborah Hung , James Gomez , Lisa Cosimi , Rob Nicol , Mark Borowsky
发明人： Andrew B. Onderdonk , Amy Barczak , Deborah Hung , James Gomez , Lisa Cosimi , Rob Nicol , Mark Borowsky
CPC分类号： C12Q1/689 , C12Q1/025 , C12Q1/6809 , C12Q1/6888 , C12Q1/6895 , C12Q1/70 , C12Q2600/112 , C12Q2600/158 , G01N2333/35 , G01N2800/52 , G01N2800/56
摘要： The specification relates generally to methods of detecting, diagnosing, and/or identifying pathogens, e.g., infectious disease pathogens and determining their drug sensitivity and appropriate methods of treatment. This invention also relates generally to methods of monitoring pathogen infection in individual subjects as well as larger populations of subjects.
摘要翻译： 本说明书一般涉及检测，诊断和/或鉴定病原体，例如感染性疾病病原体并确定其药物敏感性和适当的治疗方法的方法。 本发明一般还涉及监测个体受试者以及更大群体受试者的病原体感染的方法。
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公开(公告)号：US07026285B2
公开(公告)日：2006-04-11
申请号：US10848779
申请日：2004-05-19
CPC分类号： A61K31/715 , A61K31/785 , A61K35/742 , A61K38/00 , A61K45/06
摘要： Methods and products for inducing IL-2 secretion, inducing IL-10 secretion, activating T cells, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing postoperative surgical adhesion formation, and protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. The methods of the invention are accomplished using an immunomodulator which is a polymer having at least two repeating charge motifs separated by at least a certain minimum distance.
摘要翻译： 用于诱导IL-2分泌，诱导IL-10分泌，激活T细胞，抑制对特异性抗原的IgG抗体应答，促进同种异体移植物存活，减少术后外科粘连形成以及防止与手术，创伤或疾病相关的脓肿形成的方法和产品 提供宿主脓肿形成的易感性。 本发明的方法是使用免疫调节剂完成的，所述免疫调节剂是具有至少两个重复电荷基序的聚合物，所述至少两个重复电荷基序至少隔开一定的最小距离。
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公开(公告)号：US5700787A
公开(公告)日：1997-12-23
申请号：US502865
申请日：1995-07-14
IPC分类号： A61K47/36 , A61K31/715 , A61K39/02 , A61K39/114 , A61P31/04 , A61P37/00 , C08B37/00 , A61K31/725 , A61K31/73 , A61K31/735
CPC分类号： A61K39/02 , A61K39/0216 , A61K39/114 , Y10S424/831
摘要： Methods and products for protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. Methods for forming immunomodulators and pharmaceutical compositions relating thereto also are provided. The products useful in the invention are polysaccharides including a repeat unit having a positively charged free amino group and a negatively charged group. The preferred polysaccharide is B. fragilis capsular polysaccharide A.
摘要翻译： 提供了防止脓肿形成的方法和产品，其与手术，创伤或易引起脓肿形成的疾病相关的疾病。 还提供了形成免疫调节剂和与其有关的药物组合物的方法。 可用于本发明的产品是多糖，包括具有带正电荷的游离氨基和带负电荷的基团的重复单元。 优选的多糖是脆弱杆菌荚膜多糖A.
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公开(公告)号：US07456220B2
公开(公告)日：2008-11-25
申请号：US11176701
申请日：2005-07-07
IPC分类号： A61K31/17
CPC分类号： A61K45/06 , A61K31/17 , A61K31/265 , A61K31/452 , A61K31/5375 , Y02A50/402 , Y02A50/473 , Y10S514/825
摘要： The invention relates to immunomodulatory compositions and related methods. The immunomodulatory compositions of a formula disclosed herein are useful for the prevention of sepsis and the treatment and prevention of diseases associated with inflammation and/or NOS.
摘要翻译： 本发明涉及免疫调节组合物和相关方法。 本文公开的式的免疫调节组合物可用于预防败血症和治疗和预防与炎症和/或NOS相关的疾病。
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公开(公告)号：US07083777B1
公开(公告)日：2006-08-01
申请号：US09540024
申请日：2000-03-31
CPC分类号： A61K31/715 , A61K31/785 , A61K35/742 , A61K38/00 , A61K45/06
摘要： A pharmaceutical composition consisting of identical repeating units, each unit having a charge motif composed of a positively charged free amino moiety and a negatively charged moiety, wherein the positively charged free amino moiety and the negatively charged moiety of each charge motif are separated by at least one neutral amino acid, and wherein the positively charged free amino moiety of one of the charge motifs is separated by a distance of at least 8 amino acids from the positively charged amino moiety of another charge motif, and a pharmaceutically acceptable carrier. Said pharmaceutical composition is useful for inducing IL-2, activating T cells to produce a T helper 1 cytokine profile, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing postoperative surgical adhesion formation, and/or protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation.
摘要翻译： 由相同的重复单元组成的药物组合物，每个单元具有由带正电的游离氨基部分和带负电荷的部分组成的电荷基序，其中带电荷的游离氨基部分和每个电荷基序的带负电荷的部分至少分开 一个中性氨基酸，并且其中一个电荷基序的带正电荷的游离氨基部分与另一个电荷基序的带正电荷的氨基部分至少8个氨基酸的距离和药学上可接受的载体分开。 所述药物组合物可用于诱导IL-2，激活T细胞以产生T辅助细胞1细胞因子谱，抑制IgG抗体对特异性抗原的反应，促进同种异体移植物存活，减少术后外科粘连形成和/或防止与 手术，外伤或易导致脓肿形成的疾病。
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公开(公告)号：US5679654A
公开(公告)日：1997-10-21
申请号：US301271
申请日：1994-09-02
IPC分类号： A61K39/114 , A61K31/715 , A61K31/725 , A61K31/73 , A61K39/02
CPC分类号： A61K39/0216 , A61K39/114 , Y10S424/831
摘要： Methods and products for protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. Methods for forming immunomodulators and pharmaceutical compositions relating thereto also are provided. The products useful in the invention are polysaccharides including a repeat unit having a positively charged free amino group and a negatively charged group. The preferred polysaccharide is B. fragilis capsular polysaccharide A.
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