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公开(公告)号:US20140162985A1
公开(公告)日:2014-06-12
申请号:US14019980
申请日:2013-09-06
申请人: Andrew Burchat , Thomas D. Gordon , Kelly D. Mullen , David C. Ihle , Michael J. Morytko , Kevin P. Cusack , Gloria Y. Lo Schiavo , Lei Wang , Michael Friedman
发明人: Andrew Burchat , Thomas D. Gordon , Kelly D. Mullen , David C. Ihle , Michael J. Morytko , Kevin P. Cusack , Gloria Y. Lo Schiavo , Lei Wang , Michael Friedman
IPC分类号: C07F9/6503 , C07D401/06 , C07D471/04 , C07D401/14 , C07D491/044 , C07D231/54 , C07D417/08
CPC分类号: C07F9/65038 , C07D231/54 , C07D401/04 , C07D401/06 , C07D401/14 , C07D417/06 , C07D417/08 , C07D471/04 , C07D491/044 , C07D491/113 , C07D491/20
摘要: The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
摘要翻译: 本发明提供式(I)化合物的药学上可接受的盐,前药,生物活性代谢物,立体异构体和异构体,其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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公开(公告)号:US09193744B2
公开(公告)日:2015-11-24
申请号:US14019980
申请日:2013-09-06
申请人: Andrew Burchat , Thomas D. Gordon , Kelly D. Mullen , David C. Ihle , Michael J. Morytko , Kevin P. Cusack , Gloria Y. Lo Schiavo , Lei Wang , Michael Friedman
发明人: Andrew Burchat , Thomas D. Gordon , Kelly D. Mullen , David C. Ihle , Michael J. Morytko , Kevin P. Cusack , Gloria Y. Lo Schiavo , Lei Wang , Michael Friedman
IPC分类号: A61K31/44 , A61K31/415 , C07D471/00 , C07D491/00 , C07D498/00 , C07D513/00 , C07D515/00 , C07D231/54 , C07D487/00 , C07F9/6503 , C07D401/06 , C07D401/14 , C07D417/08 , C07D471/04 , C07D491/044 , C07D401/04 , C07D417/06 , C07D491/113 , C07D491/20
CPC分类号: C07F9/65038 , C07D231/54 , C07D401/04 , C07D401/06 , C07D401/14 , C07D417/06 , C07D417/08 , C07D471/04 , C07D491/044 , C07D491/113 , C07D491/20
摘要: The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
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公开(公告)号:US20120238549A1
公开(公告)日:2012-09-20
申请号:US13420957
申请日:2012-03-15
申请人: Kevin P. Cusack , Thomas D. Gordon , David C. Ihle , Martin E. Hayes , Eric C. Breinlinger , Anna M. Ericsson , Bin Li , Lei Wang , Gloria Y. Martinez , Andrew Burchat , Adrian D. Hobson , Kelly D. Mullen , Michael Friedman , Michael J. Morytko
发明人: Kevin P. Cusack , Thomas D. Gordon , David C. Ihle , Martin E. Hayes , Eric C. Breinlinger , Anna M. Ericsson , Bin Li , Lei Wang , Gloria Y. Martinez , Andrew Burchat , Adrian D. Hobson , Kelly D. Mullen , Michael Friedman , Michael J. Morytko
IPC分类号: A61K31/122 , C07D213/74 , A61K31/44 , C07D401/12 , A61K31/55 , C07C45/61 , C07C45/62 , C07D453/04 , A61P5/00 , A61P25/30 , A61P37/08 , A61P25/28 , A61P7/10 , A61P25/22 , A61P11/06 , A61P37/00 , A61P31/14 , A61P9/00 , A61P13/12 , A61P27/02 , A61P1/16 , A61P1/00 , A61P25/24 , A61P3/10 , A61P27/06 , A61P29/00 , A61P31/18 , A61P9/12 , A61P35/00 , A61P37/02 , A61P5/48 , A61P35/02 , A61P19/04 , A61P25/00 , A61P3/04 , A61P37/06 , A61P19/10 , A61P19/02 , A61P25/16 , A61P17/06 , A61P25/18 , A61P3/00 , A61P1/04 , A61P17/02 , C07C49/755
CPC分类号: C07D213/75 , C07B2200/07 , C07C45/62 , C07C45/72 , C07C45/74 , C07C49/755 , C07D231/54 , C07D235/18 , C07D241/20 , C07D401/04 , C07D401/12 , C07D405/12 , C07D453/04 , C07D487/06 , C07D491/20 , C07C49/67
摘要: The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
摘要翻译: 本发明提供式(I)化合物的药学上可接受的盐,前药,生物活性代谢物,立体异构体和异构体,其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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公开(公告)号:US20120053345A1
公开(公告)日:2012-03-01
申请号:US13198363
申请日:2011-08-04
申请人: Anna M. Ericson , Andrew Burchat , Kristine E. Frank , David J. Calderwood , Lily K. Abbott , Maria A. Argiriadi , David W. Borhani , Kevin P. Cusack , Richard W. Dixon , Thomas D. Gordon , Kelly D. Mullen , Robert V. Talanian , Xiaoyun Wu , Xiaolei Zhang , Lu Wang , Biqin Li , Claude E. Barberis , Neil Wishart
发明人: Anna M. Ericson , Andrew Burchat , Kristine E. Frank , David J. Calderwood , Lily K. Abbott , Maria A. Argiriadi , David W. Borhani , Kevin P. Cusack , Richard W. Dixon , Thomas D. Gordon , Kelly D. Mullen , Robert V. Talanian , Xiaoyun Wu , Xiaolei Zhang , Lu Wang , Biqin Li , Claude E. Barberis , Neil Wishart
IPC分类号: C07D495/04 , C07D401/14 , C07D403/14 , C07D231/54 , C07D487/04
CPC分类号: C07D487/04 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/14
摘要: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.
摘要翻译: 式(I)的新型化合物或其药学上可接受的盐,前体药物和式(I)的生物活性代谢物,其中取代基如本文所定义,其可用作治疗剂。
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公开(公告)号:US08008481B2
公开(公告)日:2011-08-30
申请号:US11731950
申请日:2007-04-02
申请人: Anna M. Ericsson , Andrew Burchat , Kristine E. Frank , David J. Calderwood , Lily K. Abbott , Maria A. Argiriadi , David W. Borhani , Kevin P. Cusack , Richard W. Dixon , Thomas D. Gordon , Kelly D. Mullen , Robert V. Talanian , Xiaoyun Wu , Xiaolei Zhang , Lu Wang , Biqin Li , Claude E. Barberis , Neil Wishart
发明人: Anna M. Ericsson , Andrew Burchat , Kristine E. Frank , David J. Calderwood , Lily K. Abbott , Maria A. Argiriadi , David W. Borhani , Kevin P. Cusack , Richard W. Dixon , Thomas D. Gordon , Kelly D. Mullen , Robert V. Talanian , Xiaoyun Wu , Xiaolei Zhang , Lu Wang , Biqin Li , Claude E. Barberis , Neil Wishart
IPC分类号: C07D409/14 , C07D413/14
CPC分类号: C07D487/04 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/14
摘要: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.
摘要翻译: 式(I)的新型化合物或其药学上可接受的盐,前体药物和式(I)的生物活性代谢物,其中取代基如本文所定义,其可用作治疗剂。
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公开(公告)号:US20120330012A1
公开(公告)日:2012-12-27
申请号:US13458101
申请日:2012-04-27
申请人: Kristine E. Frank , Andrew Burchat , Philip Cox , David C. Ihle , Kelly D. Mullen , Gagandeep Somal , Anil Vasudevan , Lu Wang , Noel S. Wilson
发明人: Kristine E. Frank , Andrew Burchat , Philip Cox , David C. Ihle , Kelly D. Mullen , Gagandeep Somal , Anil Vasudevan , Lu Wang , Noel S. Wilson
IPC分类号: C07D487/14
CPC分类号: C07D487/14
摘要: The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
摘要翻译: 本发明提供式(I)化合物,其药学上可接受的盐,前药,生物活性代谢物,立体异构体和异构体,其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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公开(公告)号:US08188083B2
公开(公告)日:2012-05-29
申请号:US12215338
申请日:2008-06-26
申请人: David J. Calderwood , Dominique F. Bonafoux , Andrew Burchat , Ping Ding , Kristine E. Frank , Michael Z. Hoemann , Kelly D. Mullen , Heather M. Davis
发明人: David J. Calderwood , Dominique F. Bonafoux , Andrew Burchat , Ping Ding , Kristine E. Frank , Michael Z. Hoemann , Kelly D. Mullen , Heather M. Davis
IPC分类号: A61K31/50 , C07D237/26
CPC分类号: C07D487/04 , C07D519/00
摘要: The present invention is directed to novel compounds of formula (I) wherein the variables are defined as herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
摘要翻译: 本发明涉及新的式(I)化合物,其中变量如本文所定义。 式(I)化合物可用作激酶抑制剂,因此可用于治疗某些病症和疾病,特别是炎性病症和疾病以及增殖性病症和病症,例如癌症。
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公开(公告)号:US20090270402A1
公开(公告)日:2009-10-29
申请号:US12215338
申请日:2008-06-26
申请人: David J. Calderwood , Dominique F. Bonafoux , Andrew Burchat , Ping Ding , Kristine E. Frank , Michael Z. Hoemann , Kelly D. Mullen , Heather M. Davis
发明人: David J. Calderwood , Dominique F. Bonafoux , Andrew Burchat , Ping Ding , Kristine E. Frank , Michael Z. Hoemann , Kelly D. Mullen , Heather M. Davis
IPC分类号: A61K31/4985 , C07D487/04 , C07D513/04 , A61K31/433 , A61P25/28 , A61K31/5025
CPC分类号: C07D487/04 , C07D519/00
摘要: The present invention is directed to novel compounds of formula (I) wherein the variables are defined as herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
摘要翻译: 本发明涉及新的式(I)化合物,其中变量如本文所定义。 式(I)化合物可用作激酶抑制剂,因此可用于治疗某些病症和疾病,特别是炎性病症和疾病以及增殖性病症和病症,例如癌症。
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公开(公告)号:US20070155776A1
公开(公告)日:2007-07-05
申请号:US11675183
申请日:2007-02-15
申请人: Patrick Betschmann , Andrew Burchat , David Calderwood , Michael Curtin , Steven Davidsen , Heather Davis , Robin Frey , Howard Heyman , Gavin Hirst , Peter Hrnciar , Michael Michaelides , Melanie Muckey , Kelly Mullen , Paul Rafferty , Carol Wada
发明人: Patrick Betschmann , Andrew Burchat , David Calderwood , Michael Curtin , Steven Davidsen , Heather Davis , Robin Frey , Howard Heyman , Gavin Hirst , Peter Hrnciar , Michael Michaelides , Melanie Muckey , Kelly Mullen , Paul Rafferty , Carol Wada
IPC分类号: A61K31/4745 , A61K31/4743 , A61K31/4741 , C07D491/02 , C07D498/02
CPC分类号: A61K31/4743 , A61K31/4741 , A61K31/4745 , C07D491/04 , C07D495/04 , Y02A50/401
摘要: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译: 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法,含有该化合物的组合物和使用该化合物的处理方法。
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公开(公告)号:US5637730A
公开(公告)日:1997-06-10
申请号:US699338
申请日:1996-08-19
IPC分类号: C07D207/16 , C07D521/00 , C07D207/09
CPC分类号: C07D231/12 , C07D207/16 , C07D233/56 , C07D249/08
摘要: A process for making pure sodium enalapril is provided which includes the step of decomplexing essentially pure sodium enalapril-sodium iodide complex to yield essentially pure sodium enalapril.
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