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1.Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use 失效
标题翻译: 用于抗菌的Azabicyclic氨基甲酰氧基mutilin衍生物公开(公告)号:US6121281A
公开(公告)日:2000-09-19
申请号:US230715
申请日:1999-01-29
IPC分类号: C07D487/08 , A61K31/395 , A61K31/407 , A61K31/435 , A61K31/4375 , A61K31/439 , A61P31/00 , C07C271/32 , C07C271/36 , C07C271/64 , C07C271/66 , C07C281/02 , C07C307/06 , C07C311/08 , C07C311/39 , C07C311/53 , C07C317/44 , C07C323/60 , C07C331/14 , C07D203/08 , C07D203/20 , C07D207/16 , C07D209/08 , C07D211/62 , C07D213/40 , C07D213/70 , C07D213/75 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/14 , C07D239/38 , C07D249/04 , C07D249/10 , C07D257/04 , C07D261/18 , C07D271/10 , C07D271/113 , C07D277/36 , C07D277/80 , C07D285/06 , C07D285/12 , C07D285/125 , C07D295/092 , C07D295/205 , C07D295/215 , C07D307/10 , C07D307/66 , C07D307/68 , C07D317/66 , C07D333/34 , C07D333/38 , C07D401/06 , C07D417/06 , C07D451/02 , C07D453/02 , C07D455/02 , C07D471/08 , C07D513/04 , C07H15/24
CPC分类号: C07D203/08 , C07C271/32 , C07C271/36 , C07C271/64 , C07C271/66 , C07C281/02 , C07C307/06 , C07C311/08 , C07C311/39 , C07C311/53 , C07C317/44 , C07C323/60 , C07C331/14 , C07D203/20 , C07D207/16 , C07D209/08 , C07D211/62 , C07D213/40 , C07D213/70 , C07D213/75 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/14 , C07D239/38 , C07D241/24 , C07D249/04 , C07D249/10 , C07D257/04 , C07D261/18 , C07D271/113 , C07D277/36 , C07D277/80 , C07D285/06 , C07D285/125 , C07D295/088 , C07D295/205 , C07D295/215 , C07D307/10 , C07D307/66 , C07D307/68 , C07D317/66 , C07D333/34 , C07D333/38 , C07D401/06 , C07D417/06 , C07D451/02 , C07D453/02 , C07D455/02 , C07D471/08 , C07D487/08 , C07D513/04 , C07H15/24 , C07C2101/02 , C07C2101/14 , C07C2103/82
摘要: Compounds of formula (3), and pharmaceutically acceptable salts and derivatives thereof, in which R.sup.1 is vinyl or ethyl; and R.sup.2 is a group R.sup.3, R.sup.4 CH.sub.2 --, or R.sup.5 R.sup.6 C.dbd.CH--; wherein each of R.sup.3 and R.sup.4 is an azabicyclic ring system or R.sup.5 and R.sup.6 together with the carbon atom to which they are attached form an azabicyclic ring system, are useful in the prevention and treatment of microbial infections. ##STR1##
摘要翻译: PCT No.PCT / EP97 / 04166 Sec。 371日期1999年1月29日第 102(e)日期1999年1月29日PCT提交1997年7月29日PCT公布。 公开号WO98 / 05659 日期:1998年2月12日,式(3)化合物及其药学上可接受的盐和衍生物,其中R1是乙烯基或乙基; 并且R 2是基团R 3,R 4 CH 2 - 或R 5 R 6 C = CH-; 其中R 3和R 4各自为氮杂双环系统,或者R 5和R 6与它们所连接的碳原子一起形成氮杂双环系统,可用于预防和治疗微生物感染。
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2.Carbamoyloxy derivatives of mutiline and their use as antibacterials 失效
标题翻译: 木霉素的氨基甲酰氧基衍生物及其作为抗菌剂的用途公开(公告)号:US06239175B1
公开(公告)日:2001-05-29
申请号:US09467695
申请日:1999-12-21
IPC分类号: A01N4710
CPC分类号: C07D203/08 , C07C271/32 , C07C271/36 , C07C271/64 , C07C271/66 , C07C281/02 , C07C307/06 , C07C311/08 , C07C311/39 , C07C311/53 , C07C317/44 , C07C323/60 , C07C331/14 , C07C2601/02 , C07C2601/14 , C07C2603/82 , C07D203/20 , C07D207/16 , C07D209/08 , C07D211/62 , C07D213/40 , C07D213/70 , C07D213/75 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/14 , C07D239/38 , C07D241/24 , C07D249/04 , C07D249/10 , C07D257/04 , C07D261/18 , C07D271/113 , C07D277/36 , C07D277/80 , C07D285/06 , C07D285/125 , C07D295/088 , C07D295/205 , C07D295/215 , C07D307/10 , C07D307/66 , C07D307/68 , C07D317/66 , C07D333/34 , C07D333/38 , C07D401/06 , C07D417/06 , C07D451/02 , C07D453/02 , C07D455/02 , C07D471/08 , C07D487/08 , C07D513/04 , C07H15/24
摘要: Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and derivatives thereof, in which R1 is ethyl or vinyl, Y is a carbamoyloxy group, in which the N-atom is unsubstituted, or mono- or di-substituted, are useful in the treatment of bacterial infections.
摘要翻译: 其中R1是乙基或乙烯基,Y是氨基甲酰氧基,其中N-原子是未被取代的或被单取代或二取代的式(1A)的胺的衍生物及其药学上可接受的盐和衍生物可用于 治疗细菌感染。
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3.Carbamoyloxy derivatives of mutiline and their use as antibacterials 失效
标题翻译: 木霉素的氨基甲酰氧基衍生物及其作为抗菌剂的用途公开(公告)号:US6020368A
公开(公告)日:2000-02-01
申请号:US101210
申请日:1998-12-04
IPC分类号: A61K31/00 , A61K31/325 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/397 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/429 , A61K31/433 , A61K31/435 , A61K31/439 , A61K31/44 , A61K31/445 , A61K31/4462 , A61K31/4465 , A61K31/4523 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61P31/00 , A61P31/04 , C07C269/04 , C07C271/32 , C07C271/36 , C07C271/64 , C07C271/66 , C07C281/02 , C07C307/06 , C07C311/08 , C07C311/39 , C07C311/53 , C07C317/44 , C07C323/60 , C07C331/14 , C07D203/08 , C07D203/20 , C07D205/06 , C07D207/08 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/70 , C07D213/71 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/81 , C07D213/82 , C07D213/89 , C07D231/14 , C07D239/38 , C07D249/04 , C07D249/10 , C07D249/14 , C07D257/04 , C07D261/08 , C07D261/18 , C07D271/10 , C07D271/113 , C07D277/18 , C07D277/20 , C07D277/36 , C07D277/76 , C07D277/80 , C07D285/06 , C07D285/12 , C07D285/125 , C07D285/135 , C07D295/092 , C07D295/20 , C07D295/205 , C07D295/215 , C07D307/10 , C07D307/24 , C07D307/38 , C07D307/66 , C07D307/68 , C07D317/62 , C07D317/66 , C07D333/34 , C07D333/38 , C07D333/40 , C07D401/06 , C07D417/06 , C07D451/02 , C07D453/02 , C07D455/02 , C07D471/08 , C07D487/08 , C07D513/04 , C07H15/203 , C07H15/24 , A01N47/10 , C07C261/00
CPC分类号: C07D203/08 , C07C271/32 , C07C271/36 , C07C271/64 , C07C271/66 , C07C281/02 , C07C307/06 , C07C311/08 , C07C311/39 , C07C311/53 , C07C317/44 , C07C323/60 , C07C331/14 , C07D203/20 , C07D207/16 , C07D209/08 , C07D211/62 , C07D213/40 , C07D213/70 , C07D213/75 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/14 , C07D239/38 , C07D241/24 , C07D249/04 , C07D249/10 , C07D257/04 , C07D261/18 , C07D271/113 , C07D277/36 , C07D277/80 , C07D285/06 , C07D285/125 , C07D295/088 , C07D295/205 , C07D295/215 , C07D307/10 , C07D307/66 , C07D307/68 , C07D317/66 , C07D333/34 , C07D333/38 , C07D401/06 , C07D417/06 , C07D451/02 , C07D453/02 , C07D455/02 , C07D471/08 , C07D487/08 , C07D513/04 , C07H15/24 , C07C2101/02 , C07C2101/14 , C07C2103/82
摘要: Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and derivatives thereof, in which R.sup.1 is ethyl or vinyl, Y is a carbamoyloxy group, in which the N-atom is unsubstituted, or mono- or di-substituted, are useful in the treatment of bacterial infections. ##STR1##
摘要翻译: PCT No.PCT / EP96 / 05874 Sec。 371 1998年12月4日第 102(e)日期1998年12月4日PCT 1996年12月19日PCT PCT。 公开号WO97 / 25309 日本时间1997年7月17日式(1A)的苯并咪唑衍生物及其药学上可接受的盐和衍生物,其中R1是乙基或乙烯基,Y是氨基甲酰氧基,其中N-原子是未取代的,或单 - 或二 - 取代的,可用于治疗细菌感染。
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公开(公告)号:US06878704B2
公开(公告)日:2005-04-12
申请号:US10343596
申请日:2001-08-02
申请人: Steven Aitken , Gerald Brooks , Steven Dabbs , Colin Henry Frydrych , Steven Howard , Eric Hunt
发明人: Steven Aitken , Gerald Brooks , Steven Dabbs , Colin Henry Frydrych , Steven Howard , Eric Hunt
IPC分类号: C07D237/24 , A61K31/352 , A61K31/366 , A61K31/4152 , A61K31/4375 , A61K31/44 , A61K31/4412 , A61K31/4427 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4965 , A61K31/498 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/541 , A61P17/00 , A61P27/16 , A61P31/04 , C07D213/80 , C07D213/89 , C07D215/48 , C07D215/56 , C07D231/22 , C07D237/28 , C07D239/36 , C07D239/46 , C07D239/47 , C07D239/54 , C07D239/557 , C07D239/56 , C07D241/24 , C07D241/26 , C07D241/28 , C07D309/38 , C07D311/22 , C07D311/24 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D409/12 , C07D417/06 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04 , C07D213/02
CPC分类号: C07D213/80 , C07D215/48 , C07D215/56 , C07D231/22 , C07D237/28 , C07D239/36 , C07D239/47 , C07D239/557 , C07D241/24 , C07D241/26 , C07D309/38 , C07D311/24 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要: Pleuromutilin compounds of the formula: are of use in anti-bacterial therapy.
摘要翻译: 具有下列公式的Pleuromutilin化合物:用于抗菌治疗。
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公开(公告)号:US06281226B1
公开(公告)日:2001-08-28
申请号:US09530446
申请日:2000-04-27
申请人: Valerie Berry , Steven Dabbs , Colin Henry Frydrych , Eric Hunt , Francis Dominic Sanderson , Gary Woodnutt
发明人: Valerie Berry , Steven Dabbs , Colin Henry Frydrych , Eric Hunt , Francis Dominic Sanderson , Gary Woodnutt
IPC分类号: A61K31439
CPC分类号: C07D451/02 , C07D211/20 , C07D211/54 , C07D451/04 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08
摘要: The present invention relates to pleuromutilin derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medical therapy, particularly antibacterial therapy.
摘要翻译: 本发明涉及去甲孕酮衍生物,其制备方法,含有它们的药物组合物及其在医学治疗中的用途,特别是抗菌治疗。
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6.Ether linked macrolides useful for the treatment of microbial infections 失效
标题翻译: 醚连接的大环内酯类可用于治疗微生物感染公开(公告)号:US07547679B2
公开(公告)日:2009-06-16
申请号:US11431696
申请日:2006-05-09
申请人: Sulejman Alihodzic , Drazen Pavlovic , Eric Hunt , Andrew Keith Forrest , Ivana Palej , Samra Kapic , Vlado Stimac
发明人: Sulejman Alihodzic , Drazen Pavlovic , Eric Hunt , Andrew Keith Forrest , Ivana Palej , Samra Kapic , Vlado Stimac
CPC分类号: C07H17/08
摘要: The present invention relates to 14- or 15-membered macrolides substituted at the 4″ position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a human or animal body.
摘要翻译: 本发明涉及在式(I)的4“位取代的14-或15-元大环内酯及其药学上可接受的衍生物,其制备方法及其在治疗或预防全身或局部微生物感染中的用途 人或动物体。
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7.Pleuromutilin derivatives, process for their preparation and uses thereof 审中-公开
标题翻译: Pleuromutilin衍生物,其制备方法及其应用公开(公告)号:US20070167495A1
公开(公告)日:2007-07-19
申请号:US10552238
申请日:2004-04-06
申请人: Pamela Brown , Eric Hunt
发明人: Pamela Brown , Eric Hunt
IPC分类号: A61K31/4412 , A61K31/22 , C07C323/06
CPC分类号: C07D213/80 , C07C323/62 , C07C2603/99
摘要: Pleuromutilin compounds of the formula: are of use in antibacterial therapy.
摘要翻译: 具有下列公式的Pleuromutilin化合物:用于抗菌治疗。
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公开(公告)号:US4921839A
公开(公告)日:1990-05-01
申请号:US158543
申请日:1988-02-22
申请人: Edward G. Brain , Eric Hunt , Andrew K. Forrest
发明人: Edward G. Brain , Eric Hunt , Andrew K. Forrest
IPC分类号: C07H17/08
CPC分类号: C07H17/08
摘要: Antibacterially active 11,12-carbonate derivatives of erythromycin 9-(optionally substituted)oxime and 9-imino compounds and their pharmaceutically acceptable ester or acid addition salt thereof: ##STR1## wherein R.sup.1 denotes an oxime group, a substituted oxime group, or an imino group;R.sup.3 denotes a hydrogen atom or an unsubstituted or substituted alkyl group;R.sup.7 denotes hydrogen or methyl;one of R.sup.8 and R.sup.9 denotes hydrogen, hydroxy, alkoxy, alkanoyloxy, amino, substituted amino, or a group of the formula R.sup.A --SO.sub.2 --O--, in which R.sup.A denotes an organic group, and the other of R.sup.8 and R.sup.9 denotes hydrogen, orR.sup.8 and R.sup.9 together denote an oxo group, an oxime group, or a substituted oxime group.
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公开(公告)号:US08571177B2
公开(公告)日:2013-10-29
申请号:US13037715
申请日:2011-03-01
申请人: Robert E. Thorne , Benjamin Apker , Eric Hunt
发明人: Robert E. Thorne , Benjamin Apker , Eric Hunt
IPC分类号: G01N23/207
CPC分类号: G01N23/207 , G01N23/20016
摘要: A goniometer base for X-ray crystallography comprises a magnetic steel part with a cylindrical hole, a compliant cylindrical part that is inserted into this hole, and a cylindrical tube that is press-fit into the hole and holds the compliant part in place, such that when a crystal mounting tool is inserted through the concentric holes in each part, it is positively gripped and held in place at both T=300 K and T=100 K.
摘要翻译: 用于X射线晶体学的测角器底座包括具有圆柱形孔的磁钢部分,插入该孔中的柔性圆柱形部分和压配合到孔中并将柔性部件保持在适当位置的圆柱形管, 当晶体安装工具插入每个部件中的同心孔时,它在T = 300K和T = 100K的同时被正向夹持并保持就位。
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公开(公告)号:USRE43390E1
公开(公告)日:2012-05-15
申请号:US13102156
申请日:1998-10-27
申请人: Valerie Joan Berry , Steven Dabbs , Colin Henry Frydrych , Eric Hunt , Francis Dominic Sanderson , Gary Woodnutt
发明人: Valerie Joan Berry , Steven Dabbs , Colin Henry Frydrych , Eric Hunt , Francis Dominic Sanderson , Gary Woodnutt
IPC分类号: A61K31/439 , A61K31/437 , A61K31/46 , C07D453/02 , C07D451/92
CPC分类号: C07D451/02 , C07D211/20 , C07D211/54 , C07D451/04 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08
摘要: The present invention relates to pleuromutilin derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medical therapy, particularly antibacterial therapy.
摘要翻译: 本发明涉及去甲孕酮衍生物,其制备方法,含有它们的药物组合物及其在医学治疗中的用途,特别是抗菌治疗。
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