公开(公告)号：USD554117S1

公开(公告)日：2007-10-30

申请号：US29273310

申请日：2007-03-02

申请人： Andrew Lewis ,  Allen Boothroyd ,  James Clissold ,  Kimberly A. Cooper ,  Witold Palacz

设计人： Andrew Lewis ,  Allen Boothroyd ,  James Clissold ,  Kimberly A. Cooper ,  Witold Palacz

公开(公告)号：USD481706S1

公开(公告)日：2003-11-04

申请号：US29165366

申请日：2002-08-08

申请人： Allen Boothroyd ,  William Ramsdell ,  Andrew Lewis ,  John Cronk ,  Joshua Cooper

设计人： Allen Boothroyd ,  William Ramsdell ,  Andrew Lewis ,  John Cronk ,  Joshua Cooper

公开(公告)号：US20140004201A1

公开(公告)日：2014-01-02

申请号：US13822806

申请日：2011-09-15

申请人： Andrew Lewis ,  Peter Stratford ,  Peter Geigle ,  Christine Wallrapp

发明人： Andrew Lewis ,  Peter Stratford ,  Peter Geigle ,  Christine Wallrapp

IPC分类号： A61K9/50 ,  A61K35/28

CPC分类号： A61K9/5089 ,  A61K35/28 ,  A61K48/005 ,  C12N5/0663 ,  C12N2510/02 ,  C12N2510/04 ,  C12N2800/95

摘要： The present application refers to the use of cells, e.g. mesenchymal stem cells or mesenchymal stromal cells, or any further suitable cell, encoding and secreting at least GLP-1, or a fragment or variant thereof, and preferably additionally secreting VEGF, for the prevention, treatment and/or amelioration of vascular diseases, wherein the cells, encoding and secreting at least GLP-1, or a fragment or variant thereof, and preferably additionally secreting VEGF, are encapsulated in a (spherical) microcapsule to prevent a response of the immune system of the patient to be treated. The present application also refers to the use of these (spherical) microcapsule(s) or of a pharmaceutical composition containing these cells or (spherical) microcapsule(s) for the prevention, treatment and/or amelioration of vascular diseases.

摘要翻译： 本申请涉及使用细胞，例如细胞。 间充质干细胞或间充质基质细胞，或任何进一步合适的细胞，编码和分泌至少GLP-1或其片段或变体，并且优选另外分泌VEGF，用于预防，治疗和/或改善血管疾病，其中 编码和分泌至少GLP-1或其片段或变体，优选另外分泌的VEGF的细胞被包封在（球形）微胶囊中，以防止待治疗的患者的免疫系统的反应。 本申请还涉及这些（球形）微胶囊或含有这些细胞或（球形）微胶囊的药物组合物用于预防，治疗和/或改善血管疾病的用途。

公开(公告)号：US08491524B2

公开(公告)日：2013-07-23

申请号：US13495390

申请日：2012-06-13

申请人： William Henry ,  Andrew Lewis

发明人： William Henry ,  Andrew Lewis

IPC分类号： A61M5/30 ,  A61M37/00

CPC分类号： A61M5/30 ,  B01D19/0005

摘要： A method for tilling needleless injector capsules with liquid drug, whereby dissolved gas within the drug is replaced by a less soluble gas in order to reduce the inclusion of gas bubbles, or to prevent the growth of bubbles during storage and thereby prevent breakage of the capsules.

摘要翻译： 一种用液体药物研磨无针注射器胶囊的方法，其中药物内的溶解气体被较不易溶的气体代替，以减少气泡的包含，或防止气泡在储存过程中生长，从而防止胶囊的破裂 。

公开(公告)号：US20110277870A1

公开(公告)日：2011-11-17

申请号：US13110206

申请日：2011-05-18

申请人： William Henry ,  Andrew Lewis

发明人： William Henry ,  Andrew Lewis

IPC分类号： B65B1/04

CPC分类号： A61M5/30 ,  B01D19/0005

摘要： A method for tilling needleless injector capsules with liquid drug, whereby dissolved gas within the drug is replaced by a less soluble gas in order to reduce the inclusion of gas bubbles, or to prevent the growth of bubbles during storage and thereby prevent breakage of the capsules.

摘要翻译： 一种用液体药物填充无针注射器胶囊的方法，其中药物内的溶解气体被较不易溶的气体代替，以便减少气泡的包含，或者防止气泡在储存过程中生长，从而防止胶囊的破裂 。

公开(公告)号：US07991222B2

公开(公告)日：2011-08-02

申请号：US12701371

申请日：2010-02-05

申请人： Jerry Dimsdale ,  Andrew Lewis ,  William Chen

发明人： Jerry Dimsdale ,  Andrew Lewis ,  William Chen

IPC分类号： G06K9/00 ,  H04N5/225

CPC分类号： G01C15/002 ,  G01C11/06 ,  G01C21/16 ,  G01S17/89

摘要： A system and method for imaging a three-dimensional scene having one or more objects. The system includes a light source, a detector array, a timing circuit, an inertial guidance system and a processor connected to the timing circuit and the inertial guidance system. The light source generates an optical pulse and projects the optical pulse on an object so that it is reflected as a reflected pulse. The detector array includes a plurality of detectors, wherein the detectors are oriented to receive the reflected pulse. The timing circuit determines when the reflected pulse reached detectors on the detector array. The inertial guidance system measures angular velocity and acceleration. The processor forms a composite image of the three-dimensional scene as a function of camera position and range to objects in the three-dimensional scene.

摘要翻译： 一种用于对具有一个或多个对象的三维场景进行成像的系统和方法。 该系统包括光源，检测器阵列，定时电路，惯性引导系统和连接到定时电路和惯性引导系统的处理器。 光源产生光脉冲并将光脉冲投射在物体上，使其被反射为反射脉冲。 检测器阵列包括多个检测器，其中检测器被定向以接收反射的脉冲。 定时电路确定反射脉冲何时到达检测器阵列上的检测器。 惯性导向系统测量角速度和加速度。 处理器根据相机的位置和范围与三维场景中的对象形成三维场景的合成图像。

公开(公告)号：USD605634S1

公开(公告)日：2009-12-08

申请号：US29291577

申请日：2007-09-05

申请人： Andrew Lewis ,  Erik L. van Bergen

设计人： Andrew Lewis ,  Erik L. van Bergen

公开(公告)号：US20070061235A1

公开(公告)日：2007-03-15

申请号：US11508471

申请日：2006-08-23

申请人： Mary Timmons ,  Deanna Belczak ,  Phillip Caldwell ,  Kieran Hickey ,  Thomas Lauer ,  Andrew Lewis ,  Larry Rountree ,  Matthew Severs

发明人： Mary Timmons ,  Deanna Belczak ,  Phillip Caldwell ,  Kieran Hickey ,  Thomas Lauer ,  Andrew Lewis ,  Larry Rountree ,  Matthew Severs

IPC分类号： G06Q40/00

CPC分类号： G06Q40/06

摘要： A system and method for pooling of investment funds enables a multinational corporation to cause its employee benefit plans from multiple international jurisdictions to pool their investments into a single entity, which invests in various financial products including exchange traded debt and equity securities as well as other securities. The entity is preferably structured as an offshore pooled vehicle, which may have one or more sub-funds that vary by investment objective and/or eligible investments. Each pooled vehicle is preferably organized as an Irish CCF, a Luxembourg FCP, a Dutch FGR or other tax-transparent vehicle. The investors in such pooled vehicles and sub-funds are preferably the employee benefit plans of the multinational corporation. A banking or trust organization that is duly qualified and licensed to act under the laws of the applicable jurisdiction as a management company for the pooled vehicles will act on behalf of the applicable pooled vehicle.

摘要翻译： 投资基金合并的制度和方法使跨国公司能够将多个国际管辖区的员工福利计划纳入单一实体，将其投资于各种金融产品，包括交易所交易的债务和股本证券以及其他证券 。 该实体优选地被构造为离岸合并车辆，其可以具有由投资目标和/或合格投资变化的一个或多个子资金。 每个混合车辆最好组织为爱尔兰CCF，卢森堡FCP，荷兰FGR或其他税收透明车辆。 这些合并车辆和子资金的投资者最好是跨国公司的员工福利计划。 根据适用司法管辖区的法律适当合格并获得许可，作为合并车辆的管理公司的银行或信托机构将代表适用的集体车辆行事。

公开(公告)号：US20050123501A1

公开(公告)日：2005-06-09

申请号：US10501393

申请日：2003-01-16

申请人： Andrew Lewis

发明人： Andrew Lewis

IPC分类号： A61K47/48 ,  C08F246/00 ,  A61K31/785 ,  C08F126/06

CPC分类号： C08F246/00

摘要： The present invention relates to conjugates of biologically active compounds, preferably therapeutically active compounds, with polymeric moieties having low polydispersity, as well as controlled polymerisation processes for producing the conjugates. An initiation for a controlled radical polymerisation process comprises a biologically active, usually therapeutically active, moiety and the monomer includes zwitterionic monomer for instance 2-methacryloyloxyethyl-2′-trimethylammonium ethyl phosphate inner salt. The process allows close control of the molecular weight and polydispersity of the polymeric moiety and the possibility of optimizing the delivery characteristics of the active agent.

摘要翻译： 本发明涉及生物活性化合物，优选治疗活性化合物与具有低多分散性的聚合物部分的缀合物，以及用于产生缀合物的受控聚合方法。 受控自由基聚合方法的引发包括生物活性的，通常为治疗活性的部分，并且单体包括两性离子单体，例如2-甲基丙烯酰氧基乙基-2'-三甲基铵乙基磷酸内酯盐。 该方法允许密切控制聚合物部分的分子量和多分散性以及优化活性剂的递送特性的可能性。

公开(公告)号：US09465126B2

公开(公告)日：2016-10-11

申请号：US14232879

申请日：2012-07-12

申请人： Andrew Lewis ,  Stuart Russell

发明人： Andrew Lewis ,  Stuart Russell

IPC分类号： G01V1/36 ,  G01V1/22

CPC分类号： G01V1/366 ,  G01V1/226

摘要： The present invention relates to an apparatus for use in geophysical surveying. Geophysical surveying typically involves stimulating an area of interest with a seismic source (204) and detecting the response in a sensor array. The application describes a fiber optic distributed sensing apparatus having a source (112) of electromagnetic radiation for repeatedly launching interrogating electromagnetic radiation into an optic fiber (104) deployed in said of area interest, a sampling detector (116) for sampling radiation back-scattered from the fiber; and a processor (108) arranged to process the back-scattered radiation to provide, for each of a plurality of longitudinal sensing portions of optic fiber, an indication of any incident acoustic signals affecting that sensing portion. The sampling detector is arranged to acquire a plurality of diversity samples for each said longitudinal sensing portion. The processor is configured process the diversity samples in diversity channels to determine a measurement signal indicative of any acoustic disturbance; correlate the measurement signal from each channel with a signal indicative of the seismic stimulus applied; and combine the correlated measurement signals to provide an overall measurement signal for the longitudinal sensing portion. The processor may apply a quality metric to the correlated data before performing the combination based on the quality metric. By correlating the individual diversity channels with the stimulus signal prior to performing the analysis of the measurement signal for a particular longitudinal section of optic fiber, the signal to noise ratio can be improved.

摘要翻译： 本发明涉及用于地球物理测量的装置。 地球物理测量通常涉及利用地震源（204）刺激感兴趣区域并检测传感器阵列中的响应。 该应用描述了一种具有电磁辐射源（112）的光纤分布式感测装置，用于将所述电磁辐射重新发射到在所述区域感兴趣的光纤（104）中反复发射询问电磁辐射;采样检测器（116），用于对辐射进行散射 从纤维; 以及处理器（108），其布置成处理所述反向散射辐射，以针对光纤的多个纵向感测部分中的每一个提供影响所述感测部分的任何入射声信号的指示。 采样检测器被布置成为每个所述纵向感测部分获取多个分集样本。 配置处理器处理分集通道中的分集采样以确定指示任何声学干扰的测量信号; 将来自每个通道的测量信号与指示所施加的地震激励的信号相关联; 并组合相关测量信号以提供用于纵向感测部分的总体测量信号。 基于质量度量，处理器可以在执行组合之前对相关数据应用质量度量。 通过在对光纤的特定纵向部分执行测量信号的分析之前将各个分集信道与刺激信号相关，可以提高信噪比。