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27 条记录 (耗时 0.062 秒)

    Use of cysteine derivatives for the preparation of a medicament intended to treat pathologies which result from the formation of the heterotrimeric G protein
    4.
    发明申请
    Use of cysteine derivatives for the preparation of a medicament intended to treat pathologies which result from the formation of the heterotrimeric G protein 审中-公开
    半胱氨酸衍生物用于制备旨在治疗异源三聚体G蛋白形成所致病态的药物

    公开(公告)号：US20060035899A1

    公开(公告)日：2006-02-16

    申请号：US11222601

    申请日：2005-09-09

    申请人： Gregoire Prevost ,  Marie-Odile Lonchampt ,  Thomas Gordon

    发明人： Gregoire Prevost ,  Marie-Odile Lonchampt ,  Thomas Gordon

    IPC分类号： A61K31/498

    CPC分类号： C07D487/04 ,  A61K31/223 ,  A61K31/498 ,  A61K31/4985 ,  C12N9/88 ,  Y02A50/471

    摘要： The invention relates to the use of cysteine derivatives for preparing a medicament intended to treat diseases which result from the formation of the heterotrimeric G protein. These diseases include in particular diseases linked to the following biological functions or disorders: smell, taste, perception of the light, neurotransmission, neurodegeneration, endocrine and exocrine gland functions, autocrine and paracrine regulation, arterial tension, embryogenesis, benign cell proliferation, oncogenesis, viral infection, immunological functions, diabetes, obesity, and benign :and malign proliferative diseases. Said cysteine derivatives include in particular: bis-1,1′-[7-(2-amino-1-oxo-3-thiopropyl)-8-(cyclohexylmethyl)-2-(2-methoxyphenyl)-5,6,7,8-tetrahydroimidazo[1.2a]pyrazine disulphide (I), and bis-1,1′-7-(2-amino-1-oxo-3-thiopropyl-(2-(1-naphtyl)-8-(2-methylpropyl)-5,6,7,8-tetrahydroimidazo[1.2a]pyrazin-7-yl) disulphide (II).

    摘要翻译： 本发明涉及半胱氨酸衍生物用于制备旨在治疗由异三聚体G蛋白形成引起的疾病的药物的用途。 这些疾病特别包括与以下生物功能或障碍有关的疾病：气味，味觉，感觉，神经传递，神经变性，内分泌和外分泌腺功能，自分泌和旁分泌调节，动脉张力，胚胎发生，良性细胞增殖，肿瘤形成， 病毒感染，免疫功能，糖尿病，肥胖和良性：恶性增殖性疾病。 所述半胱氨酸衍生物特别包括：双-1,1' - [7-（2-氨基-1-氧代-3-硫丙基）-8-（环己基甲基）-2-（2-甲氧基苯基）-5,6,7 ，8-四氢咪唑并[1,2a]吡嗪二硫化物（I）和双-1,1'-7-（2-氨基-1-氧代-3-硫丙基 - （2-（1-萘基）-8-（2 - 甲基丙基）-5,6,7,8-四氢咪唑并[1.2a]吡嗪-7-基）二硫化物（II）。

    System and method of employing indicia on web material and web material using same
    6.
    发明申请
    System and method of employing indicia on web material and web material using same 审中-公开
    使用相同的卷材和网状材料上的标记的系统和方法

    公开(公告)号：US20060209161A1

    公开(公告)日：2006-09-21

    申请号：US10528442

    申请日：2004-03-29

    申请人： Mark Godden ,  Lisa Brant ,  Thomas Gordon

    发明人： Mark Godden ,  Lisa Brant ,  Thomas Gordon

    IPC分类号： B41J2/315 ,  B41M5/00 ,  G01D15/10

    CPC分类号： B41J17/36 ,  B41M5/38207

    摘要： A donor web for use in a thermal transfer printer comprises a foil having a transfer side and a non-transfer side. A layer of thermal transfer material is disposed on the transfer side of the foil material. Indicia is ink-jetted to the foil. The indicia includes information pertaining to at least one of the length of used foil and the length of unused foil so that an operator can determine whether there is enough foil left for a printing operation. Preferably, the indicia is disposed on the non-transfer side and at a longitudinal edge portion of the foil in order to not affect or otherwise damage the printing portion of the foil. Also, the indicia is preferably white or black ink in order to be clearly visible against various colors of the thermal transfer material. The indicia can also be disposed on a receiver web.

    摘要翻译： 用于热转印打印机的供体幅材包括具有转印侧和非转印侧的箔。 一层热转印材料设置在箔材料的转印面上。 墨迹被喷墨到箔上。 标记包括关于使用的箔长度和未使用箔的长度中的至少一个的信息，以便操作者可以确定是否有足够的箔用于打印操作。 优选地，标记设置在箔的非转印侧和纵向边缘部分处，以便不影响或以其他方式损坏箔的印刷部分。 此外，标记优选为白色或黑色墨水，以便针对热转印材料的各种颜色清楚可见。 标记也可以放置在接收器网上。

    Warning system for turbine component contact
    7.
    发明申请
    Warning system for turbine component contact 有权
    涡轮机组件接触警告系统

    公开(公告)号：US20060159547A1

    公开(公告)日：2006-07-20

    申请号：US11035712

    申请日：2005-01-15

    申请人： Thomas Gordon ,  William Ryan ,  Lawrence Ross ,  Brian Ottinger ,  Richard Holm ,  Nicholas D'Amico ,  Phillip Gravett ,  Nancy Ulerich

    发明人： Thomas Gordon ,  William Ryan ,  Lawrence Ross ,  Brian Ottinger ,  Richard Holm ,  Nicholas D'Amico ,  Phillip Gravett ,  Nancy Ulerich

    IPC分类号： F04D29/00

    CPC分类号： F01D21/04 ,  F04D27/0292 ,  F05D2240/55 ,  F05D2260/80 ,  F05D2270/301 ,  F05D2270/305

    摘要： Aspects of the invention related to a system for providing advance notice of impending contact between a stationary component and a rotating component in a turbine engine. For example, the system can be used to warn of potential contact between a seal holder and a rotor disk in the compressor section of the engine. In one embodiment, a pad or other component can be provided on the stationary seal holder. If the seal holder and the rotor disk approach each other during operation, the pad can contact the rotor disk prior to actual contact between the seal holder and the rotor disk. An optical and/or an acoustic signal can be generated by such contact. The signals can be detected remotely from the point of contact by a signal detection device, thereby avoiding the need to pass wires through the compressor section.

    摘要翻译： 本发明的方面涉及一种用于在涡轮发动机中提供固定部件和旋转部件之间即将接触的提前通知的系统。 例如，该系统可用于警告发动机的压缩机部分中的密封保持器和转子盘之间的潜在接触。 在一个实施例中，可以在固定密封件保持器上设置垫或其它部件。 如果密封保持器和转子盘在操作期间彼此接近，则垫可以在密封保持器和转子盘之间的实际接触之前接触转子盘。 可以通过这样的接触产生光学和/或声学信号。 可以通过信号检测装置从接触点远程检测信号，从而避免需要将电线穿过压缩机部分。

    Consumable electrode arc welding
    10.
    发明申请
    Consumable electrode arc welding 失效
    消耗电极电弧焊

    公开(公告)号：US20060151453A1

    公开(公告)日：2006-07-13

    申请号：US10833297

    申请日：2004-04-27

    申请人： Thomas Gordon ,  Bernard Bednarz ,  Mark Neller ,  Michael Fanning ,  Srinivasarao Lathabai

    发明人： Thomas Gordon ,  Bernard Bednarz ,  Mark Neller ,  Michael Fanning ,  Srinivasarao Lathabai

    IPC分类号： B23K9/28

    CPC分类号： B23K9/123

    摘要： A contact tip suitable for electric arc welding has a consumable electrode. The contact tip has a body which defines a bore through which the electrode is able to pass to enable electric current from a welding power supply to be transferred from the body to the electrode. The body, in part of the length of the bore between an inlet end and an outlet end, has at least one region (herein referred to as a primary contact region) at which the body is adapted to enable primary electrical contact with the electrode, and along a remainder part of the length of the bore, the body is adapted such that any secondary contact between the body and the electrode along the remainder part does not substantially short circuit the primary electrical contact in the primary contact region of the bore.

    摘要翻译： 适用于电弧焊接的接触尖端具有消耗电极。 接触尖端具有限定孔的主体，电极可以穿过该孔，以使来自焊接电源的电流能够从主体传递到电极。 主体在入口端和出口端之间的孔的长度的一部分中具有至少一个区域（这里称为主接触区域），主体适于使得主体能够与电极初次电接触， 并且沿着孔的长度的剩余部分，本体适于使得沿着剩余部分的主体和电极之间的任何次级接触基本上不会使孔的主要接触区域中的主要电接触短路。