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    Process for purifying thioctic acid in water
    8.
    发明授权
    Process for purifying thioctic acid in water 有权
    净化西北极酸在水中的工艺

    公开(公告)号：US07547792B2

    公开(公告)日：2009-06-16

    申请号：US11909305

    申请日：2006-03-21

    申请人： Annibale Salvi ,  Antonio Nardi ,  Giacomo Bruno

    发明人： Annibale Salvi ,  Antonio Nardi ,  Giacomo Bruno

    IPC分类号： C07D339/02

    CPC分类号： C07D339/04

    摘要： Process for purifying thioctic acid in water comprising the following steps: a) dissolving the thioctic acid in an aqueous alkaline solution or alternatively dissolving a thioctic acid salt, if necessary adjusting the pH to alkaline values, b) acidifying the solution from step (a) with an acid chosen from the class consisting of sulfuric acid, phosphoric acid, methanesulfonic acid to a pH between 5.4 and 5.8. c) isolating the thioctic acid precipitated in step (b) by conventional methods.

    摘要翻译： 在水中纯化硫辛酸的方法，其包括以下步骤：a）将硫辛酸溶解在碱性水溶液中，或者如果需要，将溶解硫辛酸盐，将pH调节至碱性值，b）酸化步骤（a）的溶液， 使用选自硫酸，磷酸，甲磺酸的酸至pH在5.4至5.8之间的酸。 c）通过常规方法分离步骤（b）中沉淀的硫辛酸。

    Process for the production of r(+)&agr;-lipoic acid
    9.
    发明授权
    Process for the production of r(+)&agr;-lipoic acid 有权
    生产r（+）α-硫辛酸的方法

    公开(公告)号：US06670484B2

    公开(公告)日：2003-12-30

    申请号：US10398892

    申请日：2003-04-09

    申请人： Flavio Villani ,  Antonio Nardi ,  Annibale Salvi ,  Giovanna Falabella

    发明人： Flavio Villani ,  Antonio Nardi ,  Annibale Salvi ,  Giovanna Falabella

    IPC分类号： C07D33902

    CPC分类号： C07D339/04 ,  C07C319/06 ,  C07C323/60

    摘要： Process for the synthesis of R(+)&agr;-lipoic acid comprising the following stages: a) Salifying of racemic thioctic acid with R(+)&agr;-methylbenzylamine; b) separation by filtration of the crystallized diastereoisomeric salt of R(+)&agr;-lipoic acid-R(+)&agr;-methylbenzylamine; c) purification by re-crystallization of the diastereoisomeric salt of R(+) &agr;-lipoic acid-R(+)&agr;-methylbenzylamine, in which the re-crystallization solvent consists of a mixture of non-polar/polar solvents; d) separation of the diastereoisomeric salt to obtain R(+)&agr;-lipoic acid by reaction of said salt with acids selected from the group consisting of aliphatic hydroxy-carboxylic acids having 3 to 6 carbon atoms and aqueous phosphoric acid.

    摘要翻译： 包括以下阶段的R（+）α-硫辛酸的合成方法：a）用R（+） - α-甲基苄胺磺化外消旋硫辛酸; b）通过过滤R（+）α-硫辛酸-R（+）α-甲基苄胺的结晶非对映异构体盐分离; c）通过R（+）α-硫辛酸-R（+）α-甲基苄胺的非对映异构体盐的重结晶进行纯化，其中重结晶溶剂由非极性/极性溶剂的混合物组成; d）通过所述盐与选自具有3至6个碳原子的脂肪族羟基羧酸和磷酸水溶液的酸反应，分离非对映异构盐以获得R（+）α-硫辛酸。