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公开(公告)号:US20100204288A1
公开(公告)日:2010-08-12
申请号:US12757217
申请日:2010-04-09
申请人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaran Santhosh
发明人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaran Santhosh
IPC分类号: A61K31/426 , C07D277/54 , A61P3/10 , A61P3/06 , A61P9/12
CPC分类号: C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要: This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
摘要翻译: 本发明涉及作为葡萄糖激酶活化剂的式(I)化合物,因此可用于治疗,治疗,控制或辅助治疗疾病,其中增加葡糖激酶活性是有益的。
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公开(公告)号:US07598391B2
公开(公告)日:2009-10-06
申请号:US11453330
申请日:2006-06-14
申请人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaran Santhosh
发明人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaran Santhosh
IPC分类号: C07D277/26
CPC分类号: C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要: This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
摘要翻译: 本发明涉及作为葡萄糖激酶活化剂的式(I)化合物,因此可用于治疗,治疗,控制或辅助治疗疾病,其中增加葡糖激酶活性是有益的。
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公开(公告)号:US08263634B2
公开(公告)日:2012-09-11
申请号:US12942297
申请日:2010-11-09
申请人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswarak Santhosh
发明人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswarak Santhosh
IPC分类号: A61K31/426 , A61P3/10 , A61P3/04 , A61P3/06 , A61P9/12
CPC分类号: C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要: This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
摘要翻译: 本发明涉及作为葡萄糖激酶活化剂的式(I)化合物,因此可用于治疗,治疗,控制或辅助治疗疾病,其中增加葡糖激酶活性是有益的。
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公开(公告)号:US07851636B2
公开(公告)日:2010-12-14
申请号:US12757217
申请日:2010-04-09
申请人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaram Santhosh
发明人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaram Santhosh
IPC分类号: C07D277/20 , A61K31/426
CPC分类号: C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要: This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
摘要翻译: 本发明涉及作为葡萄糖激酶活化剂的式(I)化合物,因此可用于治疗,治疗,控制或辅助治疗疾病,其中增加葡糖激酶活性是有益的。
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公开(公告)号:US07872139B2
公开(公告)日:2011-01-18
申请号:US12188402
申请日:2008-08-08
申请人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaram Santhosh
发明人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaram Santhosh
IPC分类号: C07D417/06
CPC分类号: C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要: This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
摘要翻译: 本发明涉及作为葡萄糖激酶活化剂的式(I)化合物,因此可用于治疗,治疗,控制或辅助治疗疾病,其中增加葡糖激酶活性是有益的。
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6.HETEROARYL-UREAS AND THEIR USE AS GLUCOKINASE ACTIVATORS 有权
标题翻译: HETEROARYL-UREAS及其作为GLUCOKINASE激活剂的用途公开(公告)号:US20110060019A1
公开(公告)日:2011-03-10
申请号:US12942297
申请日:2010-11-09
申请人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswarak Santhosh
发明人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswarak Santhosh
IPC分类号: A61K31/426 , A61P3/10 , A61P3/04 , A61P3/06 , A61P9/12
CPC分类号: C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要: This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
摘要翻译: 本发明涉及作为葡萄糖激酶活化剂的式(I)化合物,因此可用于治疗,治疗,控制或辅助治疗疾病,其中增加葡糖激酶活性是有益的。
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公开(公告)号:US08211925B2
公开(公告)日:2012-07-03
申请号:US12298840
申请日:2007-04-27
申请人: Anthony Murray , Jesper Lau , Lone Jeppsen , Per Vedsø , Dharma Rao Polisetti , Bapu Reddy Gaddam , Daniel P. Christen , Kalpathy Chidambareswaran Santhosh , Jeremy T. Cooper , Robert Carl Andrews
发明人: Anthony Murray , Jesper Lau , Lone Jeppsen , Per Vedsø , Dharma Rao Polisetti , Bapu Reddy Gaddam , Daniel P. Christen , Kalpathy Chidambareswaran Santhosh , Jeremy T. Cooper , Robert Carl Andrews
IPC分类号: A61K31/426 , C07D277/44
CPC分类号: C07D277/46 , Y02P20/582
摘要: The present invention relates to N-heteroaryl-benzamides, pharmaceutical compositions comprising the same, and methods of using the same. The N-heteroaryl-benzamides are useful in diseases or medical conditions mediated by glucokinase.
摘要翻译: 本发明涉及N-杂芳基 - 苯甲酰胺,包含它们的药物组合物及其使用方法。 N-杂芳基 - 苯甲酰胺可用于由葡糖激酶介导的疾病或医学病症。
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8.N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes 有权
标题翻译: N-杂芳基吲哚羧酰胺及其类似物,用作糖尿病治疗中的葡糖激酶活化剂公开(公告)号:US08148413B2
公开(公告)日:2012-04-03
申请号:US12895761
申请日:2010-09-30
申请人: Jesper Lau , Per Vedsø , János Tibor Kodra , Anthony Murray , Lone Jeppesen , Michael Ankersen , Govindan Subramanian , Adnan M. M. Mjalli , Robert Carl Andrews , Dharma Rao Polisetti , Daniel Peter Christen
发明人: Jesper Lau , Per Vedsø , János Tibor Kodra , Anthony Murray , Lone Jeppesen , Michael Ankersen , Govindan Subramanian , Adnan M. M. Mjalli , Robert Carl Andrews , Dharma Rao Polisetti , Daniel Peter Christen
IPC分类号: A61K31/427 , C07D417/12
CPC分类号: C07D401/12 , C07D403/12 , C07D417/12 , C07D491/04
摘要: This invention relates to compounds that are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial. The compounds are of the general formula (I) wherein A and B are further defined in the application.
摘要翻译: 本发明涉及作为葡萄糖激酶活化剂的化合物,因此可用于治疗,治疗,控制或辅助治疗疾病,其中增加葡糖激酶活性是有益的。 所述化合物具有通式(I),其中A和B在本申请中进一步定义。
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9.N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes 失效
标题翻译: N-杂芳基吲哚羧酰胺及其类似物,用作糖尿病治疗中的葡糖激酶活化剂公开(公告)号:US07812043B2
公开(公告)日:2010-10-12
申请号:US11439820
申请日:2006-05-24
申请人: Jesper F Lau , Per Vedsø , János Tibor Kodra , Anthony Murray , Lone Jeppesen , Michael Ankersen , Govindan Subramanian , Adnan M. M. Mjalli , Robert Carl Andrews , Dharma Rao Polisetti , Daniel Peter Christen
发明人: Jesper F Lau , Per Vedsø , János Tibor Kodra , Anthony Murray , Lone Jeppesen , Michael Ankersen , Govindan Subramanian , Adnan M. M. Mjalli , Robert Carl Andrews , Dharma Rao Polisetti , Daniel Peter Christen
IPC分类号: A61K31/427 , C07D417/12
CPC分类号: C07D401/12 , C07D403/12 , C07D417/12 , C07D491/04
摘要: This invention relates to compounds that are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial. The compounds are of the general formula (I) wherein A and B are further defined in the application.
摘要翻译: 本发明涉及作为葡萄糖激酶活化剂的化合物,因此可用于治疗,治疗,控制或辅助治疗疾病,其中增加葡糖激酶活性是有益的。 所述化合物具有通式(I),其中A和B在本申请中进一步定义。
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10.N-HETEROARYL INDOLE CARBOXAMIDES AND ANALOGUES THEREOF, FOR USE AS GLUCOKINASE ACTIVATORS IN THE TREATMENT OF DIABETES 有权
标题翻译: N-羟基吲哚类化合物及其类似物,用作治疗糖尿病的糖尿病激活剂公开(公告)号:US20110082144A1
公开(公告)日:2011-04-07
申请号:US12895761
申请日:2010-09-30
申请人: Jesper F. Lau , Per Vedsø , János Tibor Kodra , Anthony Murray , Lone Jeppesen , Michael Ankersen , Govindan Subramanian , Adnan M. M. Mjalli , Robert Carl Andrews , Dharma Rao Polisetti , Daniel Peter Christen
发明人: Jesper F. Lau , Per Vedsø , János Tibor Kodra , Anthony Murray , Lone Jeppesen , Michael Ankersen , Govindan Subramanian , Adnan M. M. Mjalli , Robert Carl Andrews , Dharma Rao Polisetti , Daniel Peter Christen
IPC分类号: A61K31/5377 , C07D403/12 , A61K31/427 , C07D471/04 , A61K31/437 , C07D403/14 , A61K31/506 , C07D401/14 , A61K31/4439 , C07D413/14 , A61P3/10
CPC分类号: C07D401/12 , C07D403/12 , C07D417/12 , C07D491/04
摘要: This invention relates to compounds that are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial. The compounds are of the general formula (I) wherein A and B are further defined in the application.
摘要翻译: 本发明涉及作为葡萄糖激酶活化剂的化合物,因此可用于治疗,治疗,控制或辅助治疗疾病,其中增加葡糖激酶活性是有益的。 所述化合物具有通式(I),其中A和B在本申请中进一步定义。
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