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公开(公告)号:US08211925B2
公开(公告)日:2012-07-03
申请号:US12298840
申请日:2007-04-27
申请人: Anthony Murray , Jesper Lau , Lone Jeppsen , Per Vedsø , Dharma Rao Polisetti , Bapu Reddy Gaddam , Daniel P. Christen , Kalpathy Chidambareswaran Santhosh , Jeremy T. Cooper , Robert Carl Andrews
发明人: Anthony Murray , Jesper Lau , Lone Jeppsen , Per Vedsø , Dharma Rao Polisetti , Bapu Reddy Gaddam , Daniel P. Christen , Kalpathy Chidambareswaran Santhosh , Jeremy T. Cooper , Robert Carl Andrews
IPC分类号: A61K31/426 , C07D277/44
CPC分类号: C07D277/46 , Y02P20/582
摘要: The present invention relates to N-heteroaryl-benzamides, pharmaceutical compositions comprising the same, and methods of using the same. The N-heteroaryl-benzamides are useful in diseases or medical conditions mediated by glucokinase.
摘要翻译: 本发明涉及N-杂芳基 - 苯甲酰胺,包含它们的药物组合物及其使用方法。 N-杂芳基 - 苯甲酰胺可用于由葡糖激酶介导的疾病或医学病症。
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公开(公告)号:US07598391B2
公开(公告)日:2009-10-06
申请号:US11453330
申请日:2006-06-14
申请人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaran Santhosh
发明人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaran Santhosh
IPC分类号: C07D277/26
CPC分类号: C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要: This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
摘要翻译: 本发明涉及作为葡萄糖激酶活化剂的式(I)化合物,因此可用于治疗,治疗,控制或辅助治疗疾病,其中增加葡糖激酶活性是有益的。
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公开(公告)号:US20100204288A1
公开(公告)日:2010-08-12
申请号:US12757217
申请日:2010-04-09
申请人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaran Santhosh
发明人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaran Santhosh
IPC分类号: A61K31/426 , C07D277/54 , A61P3/10 , A61P3/06 , A61P9/12
CPC分类号: C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要: This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
摘要翻译: 本发明涉及作为葡萄糖激酶活化剂的式(I)化合物,因此可用于治疗,治疗,控制或辅助治疗疾病,其中增加葡糖激酶活性是有益的。
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4.HETEROARYL-UREAS AND THEIR USE AS GLUCOKINASE ACTIVATORS 有权
标题翻译: HETEROARYL-UREAS及其作为GLUCOKINASE激活剂的用途公开(公告)号:US20110060019A1
公开(公告)日:2011-03-10
申请号:US12942297
申请日:2010-11-09
申请人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswarak Santhosh
发明人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswarak Santhosh
IPC分类号: A61K31/426 , A61P3/10 , A61P3/04 , A61P3/06 , A61P9/12
CPC分类号: C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要: This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
摘要翻译: 本发明涉及作为葡萄糖激酶活化剂的式(I)化合物,因此可用于治疗,治疗,控制或辅助治疗疾病,其中增加葡糖激酶活性是有益的。
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公开(公告)号:US08263634B2
公开(公告)日:2012-09-11
申请号:US12942297
申请日:2010-11-09
申请人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswarak Santhosh
发明人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswarak Santhosh
IPC分类号: A61K31/426 , A61P3/10 , A61P3/04 , A61P3/06 , A61P9/12
CPC分类号: C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要: This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
摘要翻译: 本发明涉及作为葡萄糖激酶活化剂的式(I)化合物,因此可用于治疗,治疗,控制或辅助治疗疾病,其中增加葡糖激酶活性是有益的。
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公开(公告)号:US07851636B2
公开(公告)日:2010-12-14
申请号:US12757217
申请日:2010-04-09
申请人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaram Santhosh
发明人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaram Santhosh
IPC分类号: C07D277/20 , A61K31/426
CPC分类号: C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要: This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
摘要翻译: 本发明涉及作为葡萄糖激酶活化剂的式(I)化合物,因此可用于治疗,治疗,控制或辅助治疗疾病,其中增加葡糖激酶活性是有益的。
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公开(公告)号:US07872139B2
公开(公告)日:2011-01-18
申请号:US12188402
申请日:2008-08-08
申请人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaram Santhosh
发明人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaram Santhosh
IPC分类号: C07D417/06
CPC分类号: C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要: This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
摘要翻译: 本发明涉及作为葡萄糖激酶活化剂的式(I)化合物,因此可用于治疗,治疗,控制或辅助治疗疾病,其中增加葡糖激酶活性是有益的。
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公开(公告)号:US20090216013A1
公开(公告)日:2009-08-27
申请号:US12188402
申请日:2008-08-08
申请人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedso , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswara Santhosh
发明人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedso , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswara Santhosh
IPC分类号: C07D223/02 , C07D277/20 , C07D285/12 , C07D277/62 , C07D285/08 , C07D213/02 , C07D241/10 , C07D401/02 , C07D295/00 , C07D239/24 , C07D417/02 , C07D413/14
CPC分类号: C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要: This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
摘要翻译: 本发明涉及作为葡萄糖激酶活化剂的式(I)化合物,因此可用于治疗,治疗,控制或辅助治疗疾病,其中增加葡糖激酶活性是有益的。
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公开(公告)号:US20100331379A1
公开(公告)日:2010-12-30
申请号:US12298840
申请日:2007-04-27
申请人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedso , Dharma Rao Polisetti , Bapu Gaddam , Daniel P. Christen , Kalpathy Santhosh , Jeremy T. Cooper , Robert Carl Andrews
发明人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedso , Dharma Rao Polisetti , Bapu Gaddam , Daniel P. Christen , Kalpathy Santhosh , Jeremy T. Cooper , Robert Carl Andrews
IPC分类号: A61K31/426 , C07D277/44
CPC分类号: C07D277/46 , Y02P20/582
摘要: The present invention relates to N-heteroaryl-benzamides, pharmaceutical compositions comprising the same, and methods of using the same. The N-heteroaryl-benzamides are useful in diseases or medical conditions mediated by glucokinase.
摘要翻译: 本发明涉及N-杂芳基 - 苯甲酰胺,包含它们的药物组合物及其使用方法。 N-杂芳基 - 苯甲酰胺可用于由葡糖激酶介导的疾病或医学病症。
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公开(公告)号:US20110230458A1
公开(公告)日:2011-09-22
申请号:US13028036
申请日:2011-02-15
申请人: Devi R. Gohimukkula , David Jones , Ghassan Qabaja , Jeff J. Zhu , Jeremy T. Cooper , William K. Banner , Kurt Sundermann , Muralidhar Bondlela , Mohan Rao , Pingzhen Wang , Raju B. Gowda , Robert C. Andrews , Suparna Gupta , Anitha Hari
发明人: Devi R. Gohimukkula , David Jones , Ghassan Qabaja , Jeff J. Zhu , Jeremy T. Cooper , William K. Banner , Kurt Sundermann , Muralidhar Bondlela , Mohan Rao , Pingzhen Wang , Raju B. Gowda , Robert C. Andrews , Suparna Gupta , Anitha Hari
IPC分类号: A61K31/397 , C07D401/12 , A61K31/501 , C07D413/12 , A61K31/5377 , C07D401/14 , C07D413/14 , A61P29/00 , A61P17/00 , A61P11/00 , A61P3/10 , A61P13/12 , A61P9/00 , A61P25/00 , A61P15/10 , A61P19/10 , A61P35/04
CPC分类号: C07D401/12 , A61K31/497 , C07D237/14 , C07D237/24 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/14 , C07D451/06 , C07D453/02 , C07D471/04
摘要: The present invention provides phenyl-heteroaryl derivatives of Formula (I) and pharmaceutically acceptable salts thereof These compounds are useful in the treatment of RAGE-mediated diseases such as Alzheimer's Disease.The present invention further relates to methods for the preparation of compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the use of such compounds and/or pharmaceutical compositions in treating RAGE-mediated diseases.
摘要翻译: 本发明提供式(I)的苯基 - 杂芳基衍生物及其药学上可接受的盐。这些化合物可用于治疗RAGE介导的疾病如阿尔茨海默氏病。 本发明还涉及制备式(I)的化合物及其药学上可接受的盐,包含这些化合物的药物组合物的方法,以及这些化合物和/或药物组合物在治疗RAGE介导的疾病中的用途。
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