2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
    9.
    发明授权
    2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors 失效
    2,7-取代的八氢-1H-吡啶并[1,2-A]吡嗪衍生物作为血清素受体的配体

    公开(公告)号:US06231833B1

    公开(公告)日:2001-05-15

    申请号:US09368984

    申请日:1999-08-05

    IPC分类号: A61K4900

    CPC分类号: C07D471/04 A61K31/4985

    摘要: Substituted pyrido[1,2-a]pyrazines of general formula I; wherein Ar and Ar1 represent various carbocyclic and heterocyclic aromatic rings; A represents O, S, SO, SO2, CHOH, C═O, or —(CR3R4); and n is 0-2, as well as precursors thereto, are ligands for dopamine receptor subtypes and serotonin (5HT) within the body and are therefore useful in the treatment of disorders of the dopamine and serotonin systems:

    摘要翻译: 通式I的取代的吡啶并[1,2-a]吡嗪; 其中Ar和Ar 1表示各种碳环和杂环芳环; A表示O,S,SO,SO 2,CHOH,C = O或 - (CR 3 R 4); 和n是0-2,以及其前体是体内多巴胺受体亚型和5-羟色胺(5HT)的配体,因此可用于治疗多巴胺和血清素系统的紊乱: