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1.发明授权Thienopyrimidines containing a substituted alkyl group for pharmaceutical compositions 有权含有用于药物组合物的取代烷基的噻吩并嘧啶公开(公告)号：US08853193B2
公开(公告)日：2014-10-07
申请号：US13035023
申请日：2011-02-25
申请人： Armin Heckel , Frank Himmelsbach , Joerg Kley , Thorsten Lehmann-Lintz , Norbert Redemann , Achim Sauer , Leo Thomas , Dieter Wiedenmayer , Phillip Black , Wesley Blackaby , Ian Linney , Matthias Austen , John Danilewicz , Martin Schneider , Kay Schreiter
发明人： Armin Heckel , Frank Himmelsbach , Joerg Kley , Thorsten Lehmann-Lintz , Norbert Redemann , Achim Sauer , Leo Thomas , Dieter Wiedenmayer , Phillip Black , Wesley Blackaby , Ian Linney , Matthias Austen , John Danilewicz , Martin Schneider , Kay Schreiter
IPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61K31/56 , A61P29/00 , A61P35/00 , A61P25/28 , A61P13/12 , A61K31/395
CPC分类号： C07D495/04
摘要： The present invention relates to novel thienopyrimidine compounds of general formula pharmaceutical compositions comprising these compounds and their therapeutic use for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.
摘要翻译： 本发明涉及包含这些化合物的通式药物组合物的新型噻吩并嘧啶化合物及其用于预防和/或治疗可受到抑制Mnk1和/或Mnk2（Mnk2a或Mnk2b的激酶活性）的疾病的治疗用途 ）和/或其变体。
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![HALOGEN OR CYANO SUBSTITUTED THIENO [2,3-D]PYRIMIDINES HAVING MNK1/MNK2 INHIBITING ACTIVITY FOR PHARMACEUTICAL COMPOSITIONS](/abs-image/US/2013/03/14/US20130065914A1/abs.jpg.150x150.jpg)
2.发明申请HALOGEN OR CYANO SUBSTITUTED THIENO [2,3-D]PYRIMIDINES HAVING MNK1/MNK2 INHIBITING ACTIVITY FOR PHARMACEUTICAL COMPOSITIONS 审中-公开取代三氮唑[2,3-D]具有MNK1 / MNK2抑制活性的药物组合物的吡嗪公开(公告)号：US20130065914A1
公开(公告)日：2013-03-14
申请号：US13580184
申请日：2011-02-25
申请人： Armin Heckel , Frank Himmelsbach , Thorsten Lehmann-Lintz , Norbert Redemann , Achim Sauer , Leo Thomas , Phillip Black , Wesley Blackaby , John Danilewicz , Ian Linney , Matthias Austen , Martin Schneider , Kay Schreiter
发明人： Armin Heckel , Frank Himmelsbach , Thorsten Lehmann-Lintz , Norbert Redemann , Achim Sauer , Leo Thomas , Phillip Black , Wesley Blackaby , John Danilewicz , Ian Linney , Matthias Austen , Martin Schneider , Kay Schreiter
IPC分类号： C07D495/04 , A61P3/10 , A61P3/06 , A61P35/00 , A61P7/00 , A61P25/28 , A61P13/12 , A61P29/00 , A61K31/519 , A61P3/00
CPC分类号： C07D495/04 , A61K31/519 , Y02A50/411
摘要： The present invention relates to novel thienopyhmidine compounds of general formula (I), pharmaceutical compositions comprising these compounds and their therapeutic use for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.
摘要翻译： 本发明涉及通式（I）的新型噻吩并嘧啶化合物，包含这些化合物的药物组合物及其用于预防和/或治疗可受到抑制Mnk1和/或Mnk2的激酶活性的疾病的治疗用途 （Mnk2a或Mnk2b）和/或其变体。
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3.发明授权公开(公告)号：US08754079B2
公开(公告)日：2014-06-17
申请号：US13034855
申请日：2011-02-25
申请人： Thorsten Lehmann-Lintz , Armin Heckel , Joerg Kley , Elke Langkopf , Norbert Redemann , Achim Sauer , Leo Thomas , Dieter Wiedenmayer , Matthias Austen , John Danilewicz , Martin Schneider , Kay Schreiter , Phillip Black , Wesley Blackaby , Ian Linney
发明人： Thorsten Lehmann-Lintz , Armin Heckel , Joerg Kley , Elke Langkopf , Norbert Redemann , Achim Sauer , Leo Thomas , Dieter Wiedenmayer , Matthias Austen , John Danilewicz , Martin Schneider , Kay Schreiter , Phillip Black , Wesley Blackaby , Ian Linney
IPC分类号： C07D495/04 , A61K31/519 , A61K31/496 , A61K31/5355 , C07D413/12 , A61P25/28 , A61P29/00 , A61P35/00
CPC分类号： C07D495/04
摘要： The present invention relates to novel thienopyrimidine compounds of general formula pharmaceutical compositions comprising these compounds and their therapeutic use for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.
摘要翻译： 本发明涉及包含这些化合物的通式药物组合物的新型噻吩并嘧啶化合物及其用于预防和/或治疗可受到抑制Mnk1和/或Mnk2（Mnk2a或Mnk2b的激酶活性）的疾病的治疗用途 ）和/或其变体。
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4.发明授权Heterocycloalkyl-containing thienopyrimidines for pharmaceutical compositions 有权用于药物组合物的含杂环烷基的噻吩并嘧啶公开(公告)号：US08648068B2
公开(公告)日：2014-02-11
申请号：US13034913
申请日：2011-02-25
申请人： Thorsten Lehmann-Lintz , Joerg Kley , Norbert Redemann , Achim Sauer , Leo Thomas , Dieter Wiedenmayer , Matthias Austen , John Danilewicz , Martin Schneider , Kay Schreiter , Phillip Black , Wesley Blackaby , Ian Linney
发明人： Thorsten Lehmann-Lintz , Joerg Kley , Norbert Redemann , Achim Sauer , Leo Thomas , Dieter Wiedenmayer , Matthias Austen , John Danilewicz , Martin Schneider , Kay Schreiter , Phillip Black , Wesley Blackaby , Ian Linney
IPC分类号： C07D495/04 , A61K31/519 , A61K31/5355 , A61P35/00 , A61P25/28 , A61P3/10
CPC分类号： C07D495/04 , C07D519/00
摘要： The present invention relates to novel pharmaceutical compositions comprising thienopyrimidine compounds. Moreover, the present invention relates to the use of the thienopyrimidine compounds of the invention for the production of pharmaceutical compositions for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.
摘要翻译： 本发明涉及包含噻吩并嘧啶化合物的新型药物组合物。 此外，本发明涉及本发明的噻吩并嘧啶化合物用于生产药物组合物用于预防和/或治疗可受到抑制Mnk1和/或Mnk2（Mnk2a）激酶活性的疾病的用途 或Mnk2b）和/或其变体。
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公开(公告)号：US06617325B1
公开(公告)日：2003-09-09
申请号：US10031585
申请日：2002-05-15
申请人： Thorsten Lehmann-Lintz , Armin Heckel , Leo Thomas , Michael Mark
发明人： Thorsten Lehmann-Lintz , Armin Heckel , Leo Thomas , Michael Mark
IPC分类号： A01N4366
CPC分类号： C07D211/58
摘要： The present invention relates to biphenyl derivatives of general formula wherein Ra to Rg and n are defined as in claim 1, the isomers and salts thereof, particularly the physiologically acceptable salts thereof, which are valuable inhibitors of the microsomal triglyceride-transfer protein (MTP), medicaments containing these compounds and their use, as well as the preparation thereof.
摘要翻译： 本发明涉及通用化学式R a至R g的联苯基衍生物，n如权利要求1中所定义，它们是微粒体甘油三酯转移蛋白（MTP）的有价值的抑制剂的异构体和盐，特别是其生理上可接受的盐，药物 含有这些化合物及其用途以及其制备方法。
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6.发明授权Substituted piperazine derivatives, the preparation thereof and their use as medicaments 有权取代的哌嗪衍生物，其制备及其作为药物的用途公开(公告)号：US06821967B2
公开(公告)日：2004-11-23
申请号：US10168486
申请日：2002-10-09
申请人： Thorsten Lehmann-Lintz , Armin Heckel , Leo Thomas , Michael Mark
发明人： Thorsten Lehmann-Lintz , Armin Heckel , Leo Thomas , Michael Mark
IPC分类号： A61K31496
CPC分类号： C07D295/145 , C07C2603/18
摘要： The present invention relates to substituted piperazine derivatives of general formula wherein Ra, Rb, Rc, Rf, Rg, X, m and n are defined as in claim 1, the isomers and salts thereof, particularly the physiologically acceptable salts thereof, which are valuable inhibitors of the microsomal triglyceride-transfer protein (MTP), medicaments containing these compounds and their use, as well as the preparation thereof.
摘要翻译： 本发明涉及通式为R a，R b，R c，R f，R g，X，m和n的取代哌嗪衍生物，其权利要求1中定义为其异构体和盐，特别是其生理上可接受的盐，它们是有用的抑制剂 微粒体甘油三酯转移蛋白（MTP），含有这些化合物的药物及其用途以及其制备方法。
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7.发明申请New (hetero)aryl compounds with MCH antagonistic activity and medicaments comprising these compounds 审中-公开具有MCH拮抗活性的新（杂）芳基化合物和包含这些化合物的药物公开(公告)号：US20070111981A1
公开(公告)日：2007-05-17
申请号：US11552836
申请日：2006-10-25
申请人： Gerald Roth , Stephan Mueller , Thorsten Lehmann-Lintz , Dirk Stenkamp , Philipp Lustenberger , Joerg Kley , Klaus Rudolf , Armin Heckel , Marcus Schindler , Leo Thomas , Ralf Lotz
发明人： Gerald Roth , Stephan Mueller , Thorsten Lehmann-Lintz , Dirk Stenkamp , Philipp Lustenberger , Joerg Kley , Klaus Rudolf , Armin Heckel , Marcus Schindler , Leo Thomas , Ralf Lotz
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454
CPC分类号： C07D237/08
摘要： The present invention relates to (hetero)aryl compounds of general formula I wherein the groups and radicals A, B, Q, W, X, Y, Z, R1, R2, R4a, R4b, R5a, R5b, have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one compound according to the invention. By virtue of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.
摘要翻译： 本发明涉及通式I的（杂）芳基化合物，其中基团A，B，Q，W，X，Y，Z，R 1，R 2， R 4，R 4a，R 4b，R 5a，R 5b，R 5b具有权利要求1中给出的含义 。 此外，本发明涉及含有至少一种本发明化合物的药物组合物。 由于它们的MCH受体拮抗活性，本发明的药物组合物适用于治疗代谢紊乱和/或进食障碍，特别是肥胖症，食欲过剩，厌食症，食欲过盛和糖尿病。
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8.发明授权Substituted piperazine derivatives, the preparation thereof and their use as medicaments 有权取代的哌嗪衍生物，其制备及其作为药物的用途公开(公告)号：US06818644B1
公开(公告)日：2004-11-16
申请号：US10089024
申请日：2002-07-01
申请人： Thorsten Lehmann-Lintz , Armin Heckel , Leo Thomas , Michael Mark
发明人： Thorsten Lehmann-Lintz , Armin Heckel , Leo Thomas , Michael Mark
IPC分类号： A61K31495
CPC分类号： C07D207/335 , C07C2603/18 , C07D213/38 , C07D213/74 , C07D233/64 , C07D239/42 , C07D263/48 , C07D277/28 , C07D285/08 , C07D295/145 , C07D333/20 , C07D333/36
摘要： The present invention relates to substituted piperazine derivatives of general formula wherein Ra, Rb, Rc Rf, Rg and m, n and X are defined as in claim 1, the isomers and salts thereof, particularly the physiologically acceptable salts thereof, which are valuable inhibitors of the microsomal triglyseride-transfer protein (MTP), medicaments containing these compounds and their use, as well as the preparation thereof.
摘要翻译： 本发明涉及通式为R a，R b，R c R f，R g和m，n和X的取代哌嗪衍生物，如权利要求1中所定义，其异构体和盐，特别是其生理上可接受的盐，它们是 微粒体甘油三酯转移蛋白（MTP），含有这些化合物的药物及其用途，以及其制备方法。
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公开(公告)号：US07776830B2
公开(公告)日：2010-08-17
申请号：US11742612
申请日：2007-05-01
CPC分类号： C07H7/04 , A61K9/0019 , A61K9/02 , A61K9/2018 , A61K9/4866 , C07D309/10
摘要： Glucopyranosyl-substituted benzonitrile derivatives defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
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10.发明申请Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture 有权吡喃葡糖基取代的苄腈衍生物，含有这些化合物的药物组合物，它们的用途和制备方法公开(公告)号：US20080058379A1
公开(公告)日：2008-03-06
申请号：US11674839
申请日：2007-02-14
IPC分类号： A61K31/351 , A61K31/453 , A61P3/00 , C07D309/10 , C07D401/10
CPC分类号： C07D309/10 , C07H7/04
摘要： Glucopyranosyl-substituted benzonitrile derivatives as defined herein, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
摘要翻译： 本文定义的吡喃葡糖基取代的苄腈衍生物，包括互变异构体，其立体异构体，其混合物及其盐。 根据本发明的化合物适用于治疗代谢性疾病。
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