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1.发明申请Apparatus and Method for Simulating Arterial Blood Flow Under Various Pressure Conditions 有权在各种压力条件下模拟动脉血流的装置和方法公开(公告)号：US20110045451A1
公开(公告)日：2011-02-24
申请号：US12545599
申请日：2009-08-21
申请人： Arminas Ragauskas , Gediminas Daubaris , Rolandas Zakelis , Eugene A. Saxon , Arne H. Voie , Mailee Hess , Marc McDaniel , Timothy Myers
发明人： Arminas Ragauskas , Gediminas Daubaris , Rolandas Zakelis , Eugene A. Saxon , Arne H. Voie , Mailee Hess , Marc McDaniel , Timothy Myers
IPC分类号： G09B23/30
CPC分类号： G09B17/00 , A61B8/04 , G09B23/286
摘要： An apparatus and method for simulating human ophthalmic artery for testing of ultrasound devices is disclosed, whereby two chambers are provided and are capable of being independently pressurized, one representing the intra-cranial space and the other representing extra-cranial space, and whereby a tube running through both chambers is provided, simulating the course of the ophthalmic artery and capable of being pressurized to stimulate arterial pressure. The apparatus is operated by pressuring both chambers, and pumping a blood-imitating fluid through the vessel in a pulsatile manner.
摘要翻译： 公开了一种用于模拟人眼动脉用于超声波装置测试的装置和方法，由此提供两个腔室并且能够被独立加压，一个表示颅内空间，另一个表示颅外空间， 提供穿过两个室的模拟眼动脉的过程并能够被加压以刺激动脉压。 该装置通过对两个室进行加压操作，并以脉动方式将血液仿效流体泵送通过该容器。
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2.发明授权Apparatus and method for simulating arterial blood flow under various pressure conditions 有权用于在各种压力条件下模拟动脉血流的装置和方法公开(公告)号：US08206303B2
公开(公告)日：2012-06-26
申请号：US12545599
申请日：2009-08-21
申请人： Arminas Ragauskas , Gediminas Daubaris , Rolandas Zakelis , Eugene A. Saxon , Arne H. Voie , Mailee Hess , Marc McDaniel , Timothy Myers
发明人： Arminas Ragauskas , Gediminas Daubaris , Rolandas Zakelis , Eugene A. Saxon , Arne H. Voie , Mailee Hess , Marc McDaniel , Timothy Myers
IPC分类号： A61B8/04
CPC分类号： G09B17/00 , A61B8/04 , G09B23/286
摘要： An apparatus and method for simulating human ophthalmic artery for testing of ultrasound devices is disclosed, whereby two chambers are provided and are capable of being independently pressurized, one representing the intra-cranial space and the other representing extra-cranial space, and whereby a tube running through both chambers is provided, simulating the course of the ophthalmic artery and capable of being pressurized to stimulate arterial pressure. The apparatus is operated by pressuring both chambers, and pumping a blood-imitating fluid through the vessel in a pulsatile manner.
摘要翻译： 公开了一种用于模拟人眼动脉用于超声波装置测试的装置和方法，由此提供两个腔室并且能够被独立加压，一个表示颅内空间，另一个表示颅外空间， 提供穿过两个室的模拟眼动脉的过程并能够被加压以刺激动脉压。 该装置通过对两个室进行加压操作，并以脉动方式将血液仿效流体泵送通过该容器。
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3.发明授权Method and apparatus for determining the absolute value of intracranial pressure 有权用于确定颅内压绝对值的方法和装置公开(公告)号：US08394025B2
公开(公告)日：2013-03-12
申请号：US12492977
申请日：2009-06-26
申请人： Arminas Ragauskas , Vytautas Petkus , Romanas Chomskis , Rolandas Zakelis , Gediminas Daubaris , Mark Moehring , Eugene A. Saxon , Robert Giansiracusa , Steve Swedenburg , Renaldas Raisutis
发明人： Arminas Ragauskas , Vytautas Petkus , Romanas Chomskis , Rolandas Zakelis , Gediminas Daubaris , Mark Moehring , Eugene A. Saxon , Robert Giansiracusa , Steve Swedenburg , Renaldas Raisutis
IPC分类号： A61B8/00
CPC分类号： A61B5/031 , A61B8/06 , A61B8/0816 , A61B8/10 , A61B8/4227
摘要： A method and apparatus for obtaining the absolute value of intracranial pressure in a non-invasive manner is described by using an ultrasonic Doppler measuring device which detects the intracranial and extracranial blood flow velocities of the intracranial and extracranial segments of the ophthalmic artery. The eye in which the blood flow is monitored is subjected to an external pressure, sufficient to equalize the intracranial and extracranial angle-independent blood flow factors calculated from the intracranial velocity signal and extracranial velocity signal. The absolute value of the intracranial pressure is identified as that external pressure at which such equalization occur
摘要翻译： 通过使用检测眼动脉的颅内和颅外节段的颅内和颅外血流速度的超声多普勒测量装置来描述以非侵入性方式获得颅内压绝对值的方法和装置。 监测血流的眼睛受到外部压力，足以平衡根据颅内速度信号和颅外速度信号计算的颅内和颅外角独立血液流量因子。 颅内压的绝对值被确定为发生这种均衡的外部压力
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4.发明申请Method and Apparatus For Determining The Absolute Value Of Intracranial Pressure 有权用于确定颅内压绝对值的方法和装置公开(公告)号：US20100331684A1
公开(公告)日：2010-12-30
申请号：US12492977
申请日：2009-06-26
申请人： Arminas Ragauskas , Vytautas Petkus , Romanas Chomskis , Rolandas Zakelis , Gediminas Daubaris , Mark Moehring , Gene Saxon , Robert Giansiracusa , Steve Swedenburg
发明人： Arminas Ragauskas , Vytautas Petkus , Romanas Chomskis , Rolandas Zakelis , Gediminas Daubaris , Mark Moehring , Gene Saxon , Robert Giansiracusa , Steve Swedenburg
CPC分类号： A61B5/031 , A61B8/06 , A61B8/0816 , A61B8/10 , A61B8/4227
摘要： A method and apparatus for obtaining the absolute value of intracranial pressure in a non-invasive manner is described by using an ultrasonic Doppler measuring device which detects the intracranial and extracranial blood flow velocities of the intracranial and extracranial segments of the ophthalmic artery. The eye in which the blood flow is monitored is subjected to an external pressure, sufficient to equalize the intracranial and extracranial angle-independent blood flow factors calculated from the intracranial velocity signal and extracranial velocity signal. The absolute value of the intracranial pressure is identified as that external pressure at which such equalization occurs.
摘要翻译： 通过使用检测眼动脉的颅内和颅外节段的颅内和颅外血流速度的超声多普勒测量装置来描述以非侵入性方式获得颅内压绝对值的方法和装置。 监测血流的眼睛受到外部压力，足以平衡根据颅内速度信号和颅外速度信号计算的颅内和颅外角独立血液流量因子。 颅内压的绝对值被确定为发生这种均衡的外部压力。
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5.发明授权Method and apparatus for non-invasive continuous monitoring of cerebrovascular autoregulation state 有权用于非侵入性连续监测脑血管自身调节状态的方法和装置公开(公告)号：US08062224B2
公开(公告)日：2011-11-22
申请号：US11259831
申请日：2005-10-27
IPC分类号： A61B8/08
CPC分类号： A61B8/06 , A61B5/08 , A61B5/4064
摘要： A non-invasive method for continuous real-time monitoring of cerebrovascular blood flow autoregulation state includes simultaneous non-invasive monitoring of intracranial blood volume respiratory waves and lung volume respiratory waves, real-time decomposition of intracranial blood volume respiratory waves and lung volume respiratory waves into narrowband sinewave first harmonic components, determination therefrom of the phase shift between intracranial blood volume respiratory wave and lung volume respiratory wave first harmonics' and derivation of cerebrovascular autoregulation state from that phase shift value.
摘要翻译： 用于连续实时监测脑血管血流自动调节状态的非侵入性方法包括颅内血容量呼吸波和肺容量呼吸波的同时非侵入性监测，颅内血容量呼吸波和肺容量呼吸波的实时分解 进入窄带正弦波一次谐波分量，从其中确定颅内血量呼吸波与肺体积呼吸波一次谐波之间的相位偏移，并从该相移值推导出脑血管自身调节状态。
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6.发明授权Apparatus and method of non-invasive cerebrovascular autoregulation monitoring 有权非侵入性脑血管自动调节监测仪器及方法公开(公告)号：US07998075B2
公开(公告)日：2011-08-16
申请号：US12109873
申请日：2008-04-25
IPC分类号： A61B8/06
CPC分类号： A61B5/026 , A61B5/031 , A61B8/0808
摘要： A non-invasive method for monitoring of cerebrovascular blood flow autoregulation state includes sensing intracranial blood volume waves, filtering a slow wave, respiratory wave, and pulse wave informative components from said intracranial blood volume waves, filtering slow wave and respiratory wave reference components from the pulse wave envelope, calculating a first phase shift between said slow wave informative component and said slow wave reference component, calculating a second phase shift between said respiratory wave informative component and said respiratory wave reference component, and calculating the index of evaluation of the status of cerebral autoregulation state (ICAS) from said first phase shift and said second phase shift.
摘要翻译： 用于监测脑血管血流自动调节状态的非侵入性方法包括从所述颅内血容量波感测颅内血容积波，过滤慢波，呼吸波和脉搏波信息成分，从慢性波和呼吸波参考成分过滤 计算所述慢波信息分量和所述慢波参考分量之间的第一相移，计算所述呼吸波信息成分与所述呼吸波参考分量之间的第二相移，并计算所述慢波信息分量的状态的评估指标 所述第一相移和所述第二相移的脑自动调节状态（ICAS）。
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公开(公告)号：US20120238885A1
公开(公告)日：2012-09-20
申请号：US13487619
申请日：2012-06-04
IPC分类号： A61B5/0205
CPC分类号： A61B8/10 , A61B5/031 , A61B5/6843 , A61B8/06 , A61B8/4209 , A61B8/4227
摘要： A method and apparatus for continuously measuring the absolute intracranial pressure in a non-invasive manner is described by using an ultrasonic Doppler device which detects the pulsatility indexes of the blood flow inside the eye artery for both intracranial and extracranial eye artery portions. The eye in which the blood flow is monitored is subjected to a small pressure, sufficient to equalize the pulsatility index measurements of the internal and external portions of the eye artery. The pressure at which such equalization occurs is used as a reference for autocalibration of the apparatus so that continuous absolute intracranial pressure measurements may be taken over a particular sampling period.
摘要翻译： 通过使用检测颅内和颅外动脉部分的眼动脉内的血流的搏动指数的超声多普勒装置来描述以非侵入性方式连续测量绝对颅内压的方法和装置。 监测血流的眼睛经受足够小的压力，以均衡眼动脉的内部和外部的搏动指数测量值。 将这种均衡发生的压力用作装置的自动校准的参考，使得可以在特定采样周期上进行连续的绝对颅内压测量。
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8.发明申请Method and apparatus for non-invasive continuous monitoring of cerebrovascular autoregulation state 有权用于非侵入性连续监测脑血管自身调节状态的方法和装置公开(公告)号：US20060094964A1
公开(公告)日：2006-05-04
申请号：US11259831
申请日：2005-10-27
IPC分类号： A61B8/06
CPC分类号： A61B8/06 , A61B5/08 , A61B5/4064
摘要： A non-invasive method for continuous real-time monitoring of cerebrovascular blood flow autoregulation state includes simultaneous non-invasive monitoring of intracranial blood volume respiratory waves and lung volume respiratory waves, real-time decomposition of intracranial blood volume respiratory waves and lung volume respiratory waves into narrowband sinewave first harmonic components, determination therefrom of the phase shift between intracranial blood volume respiratory wave and lung volume respiratory wave first harmonics' and derivation of cerebrovascular autoregulation state from that phase shift value.
摘要翻译： 用于连续实时监测脑血管血流自动调节状态的非侵入性方法包括颅内血容量呼吸波和肺容量呼吸波的同时非侵入性监测，颅内血容量呼吸波和肺容量呼吸波的实时分解 进入窄带正弦波一次谐波分量，从其中确定颅内血量呼吸波与肺体积呼吸波一次谐波之间的相位偏移，并从该相移值推导出脑血管自身调节状态。
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公开(公告)号：US09168023B2
公开(公告)日：2015-10-27
申请号：US13487619
申请日：2012-06-04
CPC分类号： A61B8/10 , A61B5/031 , A61B5/6843 , A61B8/06 , A61B8/4209 , A61B8/4227
摘要： A method and apparatus for continuously measuring the absolute intracranial pressure in a non-invasive manner is described by using an ultrasonic Doppler device which detects the pulsatility indexes of the blood flow inside the eye artery for both intracranial and extracranial eye artery portions. The eye in which the blood flow is monitored is subjected to a small pressure, sufficient to equalize the pulsatility index measurements of the internal and external portions of the eye artery. The pressure at which such equalization occurs is used as a reference for autocalibration of the apparatus so that continuous absolute intracranial pressure measurements may be taken over a particular sampling period.
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公开(公告)号：US08926515B2
公开(公告)日：2015-01-06
申请号：US12121161
申请日：2008-05-15
CPC分类号： A61B8/10 , A61B5/031 , A61B5/6843 , A61B8/06 , A61B8/4209 , A61B8/4227
摘要： A method and apparatus for continuously measuring the absolute intracranial pressure in a non-invasive manner is described by using an ultrasonic Doppler device which detects the pulsatility indexes of the blood flow inside the eye artery for both intracranial and extracranial eye artery portions. The eye in which the blood flow is monitored is subjected to a small pressure, sufficient to equalize the pulsatility index measurements of the internal and external portions of the eye artery. The pressure at which such equalization occurs is used as a reference for autocalibration of the apparatus so that continuous absolute intracranial pressure measurements may be taken over a particular sampling period.
摘要翻译： 通过使用检测颅内和颅外动脉部分的眼动脉内的血流的搏动指数的超声多普勒装置来描述以非侵入性方式连续测量绝对颅内压的方法和装置。 监测血流的眼睛经受足够小的压力，以均衡眼动脉的内部和外部的搏动指数测量值。 将这种均衡发生的压力用作装置的自动校准的参考，使得可以在特定采样周期上进行连续的绝对颅内压测量。
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